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Molecular biologyPublication

How mRNA finds its way out of the cell nucleus

How does genetic information such as a genetic blueprint travel through a cell to guide the construction of proteins? A team including researchers of the Austrian Academy of Sciences has solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. The study, now published in the journal Nature, reveals the protein UAP56 at the center of the cell’s information-managing machinery.

 10.11.2025
CryoEM structure of a minimal human TREX–UAP56 complex. Subunits of the THO complex are depicted in green or blue and UAP56 in shades of pink. ©Ulrich Hohmann.

 

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Publication

Hohmann U., Graf M., Tirián L., Belén Pacheco-Fiallos B., Schellhaas U., Fin L., Handler D., Philipps AW., Riabov-Bassat D., Faraway RW., Pühringer T., Szalay MF., Roitinger E., Brennecke J., Plaschka C. An ATP-gated molecular switch orchestrates human messenger RNA export. Nature.
DOI: 10.1038/s41586-025-09832-z