Univ-Prof. Dr.

Stephen G. Young

Stephen G. Young

Corresponding Member of the Division of Mathematics and Natural Sciences abroad since 2022

  • University of California at Los Angeles (UCLA)

Contact:

Orcid-ID:

0000-0001-7270-3176

Research Areas:

  • Medical-Theoretical Sciences, Pharmacy
  • Physiology
  • Molecular pathology
  • Pathophysiology

Profile:

CV/Website

Publications:

Website

Selected Memberships:

  • National Academy of Sciences USA
  • Association of American Physicians
  • American Society for Clinical Investigation

Selected Prizes:

  • Ernst Jung Prize in Medicine
  • Inaugural Fellow of the American Society for Biochemistry and Molecular Biology
  • Doctor Honoris Causa (Medicine) University of Gothenburg, Sweden

Selected Publications:

  • Song W, Beigneux AP, Winter A-ML, Kristensen KK, Grønnemose AL, Yang Y, Tu Y, Munguia P, Morales JE, Jung H, De Jong PJ, Jung CJ, Miyashita K, Kimura T, Nakajima K, Murakami M, Birrane G, Jiang H, Tontonoz P, Ploug M, Fong LG, Young SG. (2022) Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells. J. Clin. Invest. Mar 1;132(5):e157500. doi: 10.1172/JCI157500.
  • Beigneux, AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong SG, Young SG. (2019) Lipoprotein lipase is active as a monomer. Proc. Natl. Acad. Sci. USA 116(13):6319–6328. doi: 10.1073/pnas.1900983116. PMC6442593.
  • Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. (2019) Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 116(5):1723–1732. doi: 10.1073/pnas.1817984116. PMC6358717.
  • Beigneux AP, Miyashita K, Ploug M, Blom DJ, Ai M, Linton MF, Khovidhunkit W, Dufour R, Garg A, McMahon MA, Pullinger CR, Sandoval NP, Hu X, Allan CM, Larsson M, Machida MT, Murakami M, Reue K, Tontonoz P, Goldberg IJ, Moulin P, Charrière S, Fong LG, Nakajima K, and SG Young. (2017) Autoantibodies against GPIHBP1 as a cause of hypertriglyceridemia. New Engl. J. Med. 376:1647–1658. doi: 10.1056/NEJMoa1611930. PMC 5555413.
  • Davies BS, Beigneux AP, Barnes RH II, Tu Y, Gin P, Weinstein MM, Nobumori C, Nyrén R, Goldberg I, Olivecrona G, Bensadoun A, Young SG, Fong LG. (2010) GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metabolism 12:42–52. PMC2913606.