WEDNESDAY 13.03.2024

09:30     Mentoring session

11:00     Registration

12:00     Welcome and introduction

Keynote lecture I

12:10     Hiro Nakauchi (Stanford Medicine)
The Stem Cell Niche and Beyond: xenocreated organs for rejection free transplantation

13:10    Equity, Diversity, and Inclusion (EDI) at the Vienna Biocenter

13:15    Lunch break

Session 1 - early embryogenesis

14:30     Jan Żylicz (University of Copenhagen)
Epi-metabolic coupling coordinates early development

15:00     Agnese Loda (European Molecular Biology Laboratory)
Escape from X inactivation is directly modulated by Xist RNA levels

15:15    Claudia Gerri (Max Planck Institute of Molecular Cell Biology and Genetics)
The fetal-maternal interface across species

15:45    Coffee break

16:15     Berna Sozen (Yale School of Medicine)
Stem Cell Modeling of Multicellular Organization and Patterning in Human Post-Implantation Embryonic Development

16:45    Kristina Stapornwongkul (EMBL Barcelona)
Metabolic control of germ layer proportions through regulation of Nodal and Wnt signalling

17:00    Break

Session 2 – part I - lineage specification

17:30     Vicki Metzis (Imperial College London)
Motif substitution toggles Cdx2 silencer function during posterior body formation

18:00    Alexandre Mayran (École polytechnique fédérale de Lausanne)
Cadherins modulate the self-organizing potential of gastruloids

18:15     Xavier Trepat (Institute for Bioengineering of Catalonia)
Linking force, form and function in intestinal organoids and tumoroids

18:45     Marek van Oostrom (Hubrecht Institute)
Linking molecular oscillators: coupling the segmentation clock and the cell cycle in mouse embryonic explants

19:00     Symposium dinner

THURSDAY 14.03.2024

Session 2 – part II - lineage specification

09:00     Eyal Karzbrun (Weizmann Institute of Science)
Tubular morphogenesis in a dish

09:30     Julia Batki (Max Planck Institute for Molecular Genetics)
Cell fate regulation of extraembryonic cells in the developing gut

09:45      Stefan Jahnel (Institute of Molecular Biotechnology)
Role of hyaluronic acid in morphogenesis and physiology of human cardiac organoids

10:00     Coffee break

Session 3 – nervous systems development

10:30     Fides Zenk (École polytechnique fédérale de Lausanne)
Single-cell epigenomic reconstruction of developmental trajectories in human neural organoid systems

11:00     Sakurako Nagumo Wong (Institute of Molecular Biotechnology)
Interneurons drive network pathology in tuberous sclerosis

11:15    Johan Jakobsson (Lund University Moore)
Transposable elements and the evolution of the human brain

11:45     Break

12:15     Marisa Karow (Friedrich-Alexander-Universität Erlangen-Nürnberg)
Dynamic X-chromosomal reactivation enhances female brain resilience in the context of neurodevelopment disorders

12:45     Tomohisa Toda (German Center for Neurodegenerative Diseases/Friedrich-Alexander Universität Erlangen-Nürnberg)
Life-long persistence of nuclear RNA in the mammalian brain

13:00     Group picture

13:15     Lunch break

Session 4 – part I – brain disease and regeneration

14:30    In-Hyun Park (Yale Stem Cell Center)
Generation of human diencephalic organoids to investigate neurodevelopmental disorders

15:00     Francesca Merighi (University of Pisa)
Stem cell and nanomedicine based regenerative approaches for treating spinal cord injuries  

15:15    Poster session I

18:00    Networking event: SY-Stem pub quiz

19:00    Speaker dinner [only by invitation]

Friday 15.03.2024

Session 4 – part II – brain disease and regeneration

09:00    Mina Gouti (Max Delbrück Center for Molecular Medicine) [EMBO Young Investigator Lecture]
Building advanced neuromuscular models to study human development and disease.

09:30     Daniel Del Toro (University of Barcelona)
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming

10:00     Coffee break

Session 5 – part I – novel technologies

10:30     Minhee Park (Korea Advanced Institute of Science and Technology)
To build and visualize chromatin: Understanding epigenetic memory

11:00     Nike Walther (University of California, Berkeley)
Automated live-cell single-molecule imaging reveals the molecular dynamics of overexpressed Sox9 associated with a morphological change and proliferative cell state transition in intestinal organoids

11:15     Joanna Jachowicz (Institute of Molecular Biotechnology)
Single-cell measurement of higher-order 3D genome organization with scSPRITE

11:45     Kirstin Meyer (University of California San Francisco)
Unraveling a dynamic YAP communication code for stem cell fate and proliferation

12:15     Lunch break 

13:00     Poster session II 


Session 5 – part II – novel technologies

15:00     Peter Zeller (Hubrecht Institute)
Understanding chromatin regulation during in vitro embryonic development using single-cell multi-omics

15:30    Anastasia Polikarpova (IMP - Research Institute of Molecular Pathology)
Exploring the Cellular and Molecular Landscape of Critical Bone Fractures in Axolotls

15:45    break

Keynote lecture II

16:00      Magdalena Götz (Helmholtz Munich)
Novel mechanisms of neurogenesis and neural repair

17:00     Closing remarks
17:15     Light bites & farewell