Scientific Facilities

Bioinformatics offers a wide range of support to molecular biology research groups, including data analysis, software, training, and assistance with experimental design for high-throughput biological datasets.

• Analysis of NGS and other large-scale data
• Functional and structural characterization of proteins and genomic regions
• Multi-omics data integration and functional gene-set analysis

Biooptics offers extensive services, including analytical flow cytometry and cell sorting, 30+ microscopy systems (wide-field, confocal, two-photon, light-sheet, super-resolution, TIRF, FLIM), and advanced image processing and analysis.

The Fly and Worm Facility provides micro-injections to generate transgenic animals and offers a CRISPR genome engineering service for precise knock-out and knock-in projects in Drosophila as well as several nematode species, including C. elegans.

Molecular Biology Services provides services including Sanger Sequencing, E. coli cell preparation, recombinant protein production, mycoplasma testing, and plasmid preparation in 96-well format, along with molecular biology reagents, high-throughput lab automation, and access to a RIKEN clone repository.

Organoid Research Facility is a specialized IMBA center focused on advancing organoid-based research.

Peptide Synthesis specializes in peptide synthesis with options for modifications or heavy isotope-labeled amino acids, and conducts purification of antibodies and other proteins, complemented by small-scale RP-HPLC purifications and TAQ purification in collaboration with MBS.

The Proteomics Facility provides mass spectrometry service for protein identification, characterization of post-translational modifications and protein quantitation which includes sample preparation, MS measurement and the respective data interpretation. The facility operates a number of state-of-the-art mass spectrometers that are provided by the VBCF.

With single cell proteomics (SCP) and crosslinking mass spectrometry (XL-MS), the Proteomics Tech Hub currently focuses on two major lines of research and technological innovation both holding great relevance to the Vienna BioCenter research community.

The Stem Cell Core Facility offers key services like human iPS reprogramming, genome targeting in mouse and human stem cells, quality control of cell lines and biobanking, which is enabled by established collaborations with research institutions. In addition, the facility offers hands-on training to individual and/or groups of scientists who want to advance their skills and knowledge in the field of stem cell research.

TheTransgenic Service Department assists in-house investigators by offering services for the creation and preservation of genetically engineered laboratory animal strains.

Austrian Bioimaging/CMI serves as the national node for Euro-BioImaging, part of the European Research Infrastructure Consortium (ERIC), and provides open access to a broad range of imaging technologies and data services, supporting research and training in biological and biomedical imaging.

Child Care Center advocates for career-family balance by offering childcare for children aged three months to six years for employees at the Vienna BioCenter.

Computational Biology Training is part of the Vienna BioCenter Scientific Training program and provides practical courses on computational data analysis.

ElectronMicroscopy offers training and assisted techniques in electron microscopy, including standard methods and advanced cryo-EM for high-resolution imaging, as well as basic scanning EM for surface structure visualization.

Histology equips researchers with diverse equipment and expertise to preserve and visualize the microanatomy of their model organisms utilizing classical tissue processing, histochemistry, immunostaining, and in-situ hybridization methods, as well as multidisciplinary approaches, such as spatial transcriptomics, tissue clearing, and multiplex immunofluorescence.

Metabolomics offers quantitative analysis of small molecules and metabolites using LC-MS/MS, combining liquid separation techniques with advanced mass analysis, enabling targeted and nontargeted insights into metabolic pathways and genome-environment interactions.

Next Generation Sequencing provides DNA and RNA sequencing across short (Illumina) and long-read (PacBio and ONT) platforms. A broad selection of library preparation protocols allows for processing samples from many biomedical research areas. The diverse portfolio comprises customized approaches, user consultation, robotics services, and bioinformatic analysis.

Plant Sciences (PlantS) operates a state-of-the-art, high-throughput, multi-sensor plant phenotyping research infrastructure (PHENOPlant) and 23 highly specialized phytotrons. We offer expertise and service in high-throughput plant phenotyping, dynamic environmental simulations, soft- and hardware engineering as well as image- and data analysis.

PreclinicalPhenotyping (pcPHENO) specializes in advanced mouse in vivo studies covering behavior tests, metabolic and cardiovascular measurements, as well as surgical services.

Protein Technologies (ProTech) aims to advance research in molecular and cell biology, protein biochemistry, and structural biology by offering expertise in recombinant protein technologies and biophysical characterization, with core services including molecular cloning, protein production, purification, and analysis.