NanoTrust-Advanced

Nanocarriers are innovative delivery and encapsulation systems with different chemical compositions and structures and are classified as advanced materials. They are used in a variety of applications, especially in medicine, cosmetics, and agriculture, as well as in food supplements and household products. Nanocarriers can protect sensitive active ingredients, delay their release, and even enable targeted delivery to the site of action, thereby increasing effectiveness and reducing any side effects. In the scientific literature, the term “nanocarrier” covers not only nanomaterials up to a size of 100 nm according to the definition proposed by the European Commission, but also structures up to 1,000 nm. At present, there is no uniform definition or categorisation of nanocarriers. In this dossier, they are classified on the basis of their origin and chemical composition, and categorised as organic, inorganic, and hybrid systems (material combinations of organic and inorganic materials) as well as supraparticles. To date, there has been little research on how nanocarrier systems behave in the various environmental compartments (soil, water, air). Analytical challenges and the lack of standardised test protocols make comprehensive risk assessments difficult.

Quantum dots (QDs) are increasingly widespread in medicine and environmental research. Because of their specific optical characteristics, QDs can be detected by fluorescence analyses, even in complex media, such as environmental or tissue samples. Their unique properties make them useful for a variety of applications, such as for the use as fluorescent markers for cells, as contrast agents in deep tissue and tumour imaging, in biosensing or photodynamic therapy, and for targeted drug delivery. As a result, QDs could potentially be used as detectable and clearly identifiable “nanotracers” to mark or detect specific targets or to be able to draw general conclusions about the fate of engineered nanoparticles (ENPs) in environmentally relevant media, e.g. in wastewater. QDs mainly consist of metallic semiconductor compounds, such as cadmium selenide (CdSe), cadmium telluride (CdTe), lead sulphide (PbS) or indium phosphide (InP), which can have toxic effects on cells and organisms. Research is therefore being conducted on non­toxic carbon­based QDs, amongst others. QDs are already being used in products, such as TV screens and novel solar cell technologies. However, with an increasing number of applications and thusan increase in production volumes, potential exposure is also intensifying. Consequently, risks to humans and the environment are increasing as accidental release and resulting negative effects cannot be ruled out. To date,however, only limited data exist on possible environmental and health risks.

Quantum dots (QDs) are increasingly widespread in medicine and environmental research. Because of their specific optical characteristics, QDs can be detected by fluorescence analyses, even in complex media, such as environmental or tissue samples. Their unique properties make them useful for a variety of applications, such as for the use as fluorescent markers for cells, as contrast agents in deep tissue and tumour imaging, in biosensing or photodynamic therapy, and for targeted drug delivery. As a result, QDs could potentially be used as detectable and clearly identifiable “nanotracers” to mark or detect specific targets or to be able to draw general conclusions about the fate of engineered nanoparticles (ENPs) in environmentally relevant media, e.g. in wastewater. QDs mainly consist of metallic semiconductor compounds, such as cadmium selenide (CdSe), cadmium telluride (CdTe), lead sulphide (PbS) or indium phosphide (InP), which can have toxic effects on cells and organisms. Research is therefore being conducted on non­toxic carbon­based QDs, amongst others. QDs are already being used in products, such as TV screens and novel solar cell technologies. However, with an increasing number of applications and thusan increase in production volumes, potential exposure is also intensifying. Consequently, risks to humans and the environment are increasing as accidental release and resulting negative effects cannot be ruled out. To date,however, only limited data exist on possible environmental and health risks.