Bachmaier, K., Le, J., Penninger, JM. (2000). "Catching heart disease": antigenic mimicry and bacterial infections. Nat Med. 6(8):841-2

Hanada, R., Penninger, JM. (2011). [Central regulation of body temperature by RANKL/RANK pathway]. Clin Calcium. 21(8):1201-8

Sasaki, T., Sasaki, J., Suzuki, A., Penninger, JM. (2001). [Involvement of phosphoinositide 3-kinases and phosphoinositide phosphatases in immune responses, glucose metabolism and tumorigenesis]. Tanpakushitsu Kakusan Koso. 46(12):1820-9

Imai, Y., Kuba, K., Penninger, JM. (2008). [Lessons from SARS: a new potential therapy for acute respiratory distress syndrome (ARDS) with angiotensin converting enzyme 2 (ACE2)]. Masui. 57(3):302-10

Penninger, J. (1991). [Phenotypic and functional analysis of thymic nurse cell (TNC)-lymphocytes]. Wien Klin Wochenschr. 103(2):45-50

van der Harst, P., van Setten, J., Verweij, N (...) Samani, NJ., de Bakker, PIW. (2016). 52 Genetic Loci Influencing Myocardial Mass. J Am Coll Cardiol. 68(13):1435-1448

Onji, M., Werschler, N., Penninger, J. (2021). A critical relationship between bone and fat: the role of bone marrow adipose-derived RANKL in bone metabolism. EMBO Rep. 22(7):e52986

Hagelkruys, A., Wirnsberger, G., Stadlmann, J (...) Klein, C., Penninger, JM. (2021). A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans. J Exp Med. 218(1)

Kuba, K., Imai, Y., Rao, S (...) Jiang, C., Penninger, JM. (2005). A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 11(8):875-9

Polizzotti, BD., Ganapathy, B., Haubner, BJ., Penninger, JM., Kühn, B. (2016). A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nat Protoc. 11(3):542-52

Garreta, E., Prado, P., Stanifer, ML (...) Penninger, JM., Montserrat, N. (2022). A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells. Cell Metab.

Rao, S., Tortola, L., Perlot, T (...) Kroemer, G., Penninger, JM. (2014). A dual role for autophagy in a murine model of lung cancer. Nat Commun. 5:3056

Zoranovic, T., Manent, J., Willoughby, L (...) Richardson, HE., Penninger, JM. (2018). A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer. PLoS Genet. 14(10):e1007688

Neely, GG., Hess, A., Costigan, M (...) Woolf, CJ., Penninger, JM. (2010). A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell. 143(4):628-38

Andritschke, D., Dilling, S., Emmenlauer, M (...) Dehio, C., Hardt, WD. (2016). A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion. PLoS One. 11(9):e0161965

Neely, GG., Kuba, K., Cammarato, A (...) Bodmer, R., Penninger, JM. (2010). A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 141(1):142-53

Quintard, C., Tubbs, E., Jonsson, G (...) Penninger, JM., Gidrol, X. (2024). A microfluidic platform integrating functional vascularized organoids-on-chip. Nat Commun. 15(1):1452

Chan, JF., Oh, YJ., Yuan, S (...) Yuen, KY., Markovitz, DM. (2022). A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo. Cell Rep Med. :100774

Musteanu, M., Blaas, L., Zenz, R (...) Casanova, E., Eferl, R. (2012). A mouse model to identify cooperating signaling pathways in cancer. Nat Methods. 9(9):897-900

Rangachari, M., Eriksson, U., Vollmann, EH., Penninger, JM. (2005). A novel model for pathogenesis of autoimmune heart failure: the role of dendritic cells. International Congress Series (Uehara Foundation Review). 1285:192-201

Douni, E., Rinotas, V., Makrinou, E (...) Schett, G., Kollias, G. (2012). A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Hum Mol Genet. 21(4):784-98

Haubner, BJ., Schuetz, T., Penninger, JM. (2016). A reproducible protocol for neonatal ischemic injury and cardiac regeneration in neonatal mice. Basic Res Cardiol. 111(6):64

Elling, U., Wimmer, RA., Leibbrandt, A (...) Stark, A., Penninger, JM. (2017). A reversible haploid mouse embryonic stem cell biobank resource for functional genomics. Nature. 550(7674):114-118

Xiol, J., Cora, E., Koglgruber, R (...) Sachidanandam, R., Pillai, RS. (2012). A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Mol Cell. 47(6):970-9

Bony, C., Roche, S., Shuichi, U (...) Mano, H., Pucéat, M. (2001). A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J Cell Biol. 152(4):717-28

Danilczyk, U., Eriksson, U., Crackower, MA., Penninger, JM. (2003). A story of two ACEs. J Mol Med (Berl). 81(4):227-34

Beveridge, R., Stadlmann, J., Penninger, JM., Mechtler, K. (2020). A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes. Nat Commun. 11(1):742

Taubenschmid, J., Stadlmann, J., Jost, M (...) Koerner, C., Penninger, JM. (2017). A vital sugar code for ricin toxicity. Cell Res. 27(11):1351-1364

Taubenschmid-Stowers, J., Orthofer, M., Laemmerer, A (...) Horn, M., Penninger, JM. (2023). A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors. EMBO Mol Med. 15(3):e16959

Kiechl, S., Schramek, D., Widschwendter, M (...) Schett, G., Penninger, JM. (2017). Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer. Oncotarget. 8(3):3811-3825

Perlot, T., Penninger, JM. (2013). ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition. Microbes Infect. 15(13):866-73

Jin, HY., Song, B., Oudit, GY (...) Penninger, JM., Zhong, JC. (2012). ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. PLoS One. 7(6):e38502

Patel, VB., Mori, J., McLean, BA (...) Lopaschuk, GD., Oudit, GY. (2016). ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes. 65(1):85-95

Gawish, R., Starkl, P., Pimenov, L (...) Penninger, JM., Knapp, S. (2022). ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology. Elife. 11

Hashimoto, T., Perlot, T., Rehman, A (...) Rosenstiel, P., Penninger, JM. (2012). ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487(7408):477-81

Yamaguchi, T., Hoshizaki, M., Minato, T (...) Imai, Y., Kuba, K. (2021). ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury. Nat Commun. 12(1):6791

Minato, T., Yamaguchi, T., Hoshizaki, M (...) Imai, Y., Kuba, K. (2022). ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury. PLoS One. 17(7):e0270920

Kong, YY., Feige, U., Sarosi, I (...) Boyle, WJ., Penninger, JM. (1999). Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 402(6759):304-9

Eriksson, U., Kurrer, MO., Sonderegger, I (...) Penninger, JM., Kopf, M. (2003). Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. J Exp Med. 197(3):323-31

Yao, Z., Diener, K., Wang, XS (...) Woodgett, JP., Penninger, JM. (1997). Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. J Biol Chem. 272(51):32378-83

Griffiths, EK., Penninger, JM. (2002). ADAP-ting TCR signaling to integrins. Sci STKE. 2002(127):re3

Matsumoto, G., Omi, Y., Lee, U (...) Shindo, J., Penninger, JM. (2000). Adhesion mediated by LFA-1 is required for efficient IL-12-induced NK and NKT cell cytotoxicity. Eur J Immunol. 30(12):3723-31

Hinterleitner, R., Gruber, T., Pfeifhofer-Obermair, C (...) Wolf, D., Baier, G. (2012). Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model. PLoS One. 7(9):e44295

Moll, HP., Pranz, K., Musteanu, M (...) Popper, H., Casanova, E. (2018). Afatinib restrains K-RAS-driven lung tumorigenesis. Sci Transl Med. 10(446)

Yamasaki, T., Deki-Arima, N., Kaneko, A (...) Shibata, S., Nishina, H. (2017). Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Sci Rep. 7(1):7348

Candé, C., Vahsen, N., Kouranti, I (...) Penninger, JM., Kroemer, G. (2004). AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene. 23(8):1514-21

Vahsen, N., Candé, C., Brière, JJ (...) Rustin, P., Kroemer, G. (2004). AIF deficiency compromises oxidative phosphorylation. EMBO J. 23(23):4679-89

Li, T., Sun, Y., Zhang, S (...) Blomgren, K., Zhu, C. (2022). AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia-Ischemia Injury. Mol Neurobiol.

Rao, S., Mondragón, L., Pranjic, B (...) Kroemer, G., Penninger, JM. (2019). AIF-regulated oxidative phosphorylation supports lung cancer development. Cell Res. 29(7):579-591

Joza, N., Pospisilik, JA., Hangen, E (...) Penninger, JM., Kroemer, G. (2009). AIF: not just an apoptosis-inducing factor. Ann N Y Acad Sci. 1171:2-11

Penninger, JM., Timms, E., Shahinian, A (...) Hedrick, SM., Mak, TW. (1995). Alloreactive gamma delta thymocytes utilize distinct costimulatory signals from peripheral T cells. J Immunol. 155(8):3847-55

Wallace, VA., Penninger, JM., Kishihara, K (...) Ohashi, PS., Mak, TW. (1997). Alterations in the level of CD45 surface expression affect the outcome of thymic selection. J Immunol. 158(7):3205-14

Senovilla, L., Vitale, I., Martins, I (...) Castedo, M., Kroemer, G. (2012). An immunosurveillance mechanism controls cancer cell ploidy. Science. 337(6102):1678-84

Stadlmann, J., Hoi, DM., Taubenschmid, J., Mechtler, K., Penninger, JM. (2018). Analysis of PNGase F-Resistant N-Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities. Proteomics. 18(13):e1700436

Kuba, K., Imai, Y., Penninger, JM. (2005). Angiotensin converting enzyme 2 (ACE2) and SARS infections. Experimental Medicine. 23:2830-5

Rey-Parra, GJ., Vadivel, A., Coltan, L (...) Oudit, GY., Thébaud, B. (2012). Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury. J Mol Med (Berl). 90(6):637-47

Lovren, F., Pan, Y., Quan, A (...) Penninger, JM., Verma, S. (2008). Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol. 295(4):H1377-84

Huang, F., Guo, J., Zou, Z (...) Jiang, C., Li, L. (2014). Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nat Commun. 5:3595

Oudit, GY., Kassiri, Z., Patel, MP (...) Khokha, R., Penninger, JM. (2007). Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res. 75(1):29-39

Zhang, H., Penninger, JM., Li, Y., Zhong, N., Slutsky, AS. (2020). Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 46(4):586-590

Imai, Y., Kuba, K., Ohto-Nakanishi, T., Penninger, JM. (2010). Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3):405-10

Kuba, K., Yamaguchi, T., Penninger, JM. (2021). Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19. Front Immunol. 12:732690

Yang, P., Gu, H., Zhao, Z (...) Jiang, C., Wang, X. (2014). Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Sci Rep. 4:7027

Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 (ACE2)-mediated regulation of cardiovascular peptides and its application for treating disease. Experimental Medicine. 24:71-77

Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 (ACE2)-mutant mice. Respiratory Molecular Medicine. 10:38-42

Lo, J., Patel, VB., Wang, Z (...) Penninger, JM., Oudit, GY. (2013). Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats. Exp Physiol. 98(1):109-22

Song, B., Jin, H., Yu, X (...) Penninger, JM., Zhong, JC. (2013). Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. Regul Pept. 185:44-51

Imai, Y., Kuba, K., Penninger, JM. (2007). Angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Cell Mol Life Sci. 64(15):2006-12

Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 in lung diseases. Curr Opin Pharmacol. 6(3):271-6

Crackower, MA., Sarao, R., Oudit, GY (...) Yagil, Y., Penninger, JM. (2002). Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 417(6891):822-8

Zou, Z., Yan, Y., Shu, Y (...) Penninger, JM., Jiang, C. (2014). Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nat Commun. 5:3594

Imai, Y., Kuba, K., Rao, S (...) Jiang, C., Penninger, JM. (2005). Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 436(7047):112-6

Zhong, J., Basu, R., Guo, D (...) Kassiri, Z., Oudit, GY. (2010). Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation. 122(7):717-28, 18 p following 728

Oudit, GY., Wang, K., Viveiros, A., Kellner, MJ., Penninger, JM. (2023). Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic. Cell. 186(5):906-922

Danilczyk, U., Penninger, JM. (2006). Angiotensin-converting enzyme II in the heart and the kidney. Circ Res. 98(4):463-71

Osterreicher, CH., Taura, K., De Minicis, S (...) Penninger, JM., Brenner, DA. (2009). Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 50(3):929-38

Wada, T., Stepniak, E., Hui, L (...) Wagner, EF., Penninger, JM. (2008). Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ. 15(1):89-93

Zhang, J., Shehabeldin, A., da Cruz, LA (...) Penninger, JM., Siminovitch, KA. (1999). Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med. 190(9):1329-42

Yoshida, H., Kong, YY., Yoshida, R (...) Penninger, JM., Mak, TW. (1998). Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell. 94(6):739-50

Yamada, D., Kojima, Y., Hosoya, A (...) Okamoto, R., Nagaishi, T. (2023). Apelin expression is downregulated in T cells in a murine model of chronic colitis. Biochem Biophys Res Commun. 647:72-79

Uribesalgo, I., Hoffmann, D., Zhang, Y (...) Haubner, BJ., Penninger, JM. (2019). Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy. EMBO Mol Med. 11(8):e9266

Zhang, ZZ., Wang, W., Jin, HY (...) Oudit, GY., Zhong, JC. (2017). Apelin Is a Negative Regulator of Angiotensin II-Mediated Adverse Myocardial Remodeling and Dysfunction. Hypertension. 70(6):1165-1175

Sato, T., Suzuki, T., Watanabe, H (...) Imai, Y., Kuba, K. (2013). Apelin is a positive regulator of ACE2 in failing hearts. J Clin Invest. 123(12):5203-11

Wang, W., Shen, M., Fischer, C (...) Kassiri, Z., Oudit, GY. (2019). Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proc Natl Acad Sci U S A. 116(26):13006-13015

Attané, C., Foussal, C., Le Gonidec, S (...) Valet, P., Castan-Laurell, I. (2012). Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes. 61(2):310-20

Ferri, KF., Jacotot, E., Blanco, J (...) Penninger, JM., Kroemer, G. (2000). Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases. J Exp Med. 192(8):1081-92

Lorenzo, HK., Susin, SA., Penninger, J., Kroemer, G. (1999). Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ. 6(6):516-24

Vitale, I., Pietrocola, F., Guilbaud, E (...) Kroemer, G., Galluzzi, L. (2023). Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. :1-58

Kawahara, R., Chernykh, A., Alagesan, K (...) Packer, NH., Thaysen-Andersen, M. (2021). Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. Nat Methods.

Olie, CS., van der Wal, E., Cikes, D (...) Kessler, BM., Raz, V. (2021). Author Correction: Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability. Sci Rep. 11(1):6429

Cikes, D., Elsayad, K., Sezgin, E (...) Banka, S., Penninger, JM. (2023). Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. Nat Metab.

Eriksson, U., Penninger, JM., Kopf, M. (2005). Autoimmune heart disease: from bench to bedside. Drug Discovery Today: Disease Mechanisms, online edition.

Eriksson, U., Penninger, JM. (2005). Autoimmune heart failure: new understandings of pathogenesis. Int J Biochem Cell Biol. 37(1):27-32

Klionsky, DJ., Petroni, G., Amaravadi, RK (...) Galluzzi, L., Pietrocola, F. (2021). Autophagy in major human diseases. EMBO J. :e108863

Galluzzi, L., Pietrocola, F., Bravo-San Pedro, JM (...) Ryan, KM., Kroemer, G. (2015). Autophagy in malignant transformation and cancer progression. EMBO J. 34(7):856-80

Rao, S., Yang, H., Penninger, JM., Kroemer, G. (2014). Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance. Autophagy. 10(3):529-31

Manent, J., Banerjee, S., de Matos Simoes, R (...) Humbert, PO., Richardson, HE. (2017). Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species. Oncogene. 36(40):5658-5660

Manent, J., Banerjee, S., de Matos Simoes, R (...) Humbert, PO., Richardson, HE. (2017). Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species. Oncogene. 36(40):5576-5592

Minato, T., Nirasawa, S., Sato, T (...) Takahashi, S., Kuba, K. (2020). B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Nat Commun. 11(1):1058

Landmann, J., Richter, F., Classen, J (...) Penninger, JM., Bechmann, I. (2019). Behavioral phenotyping of calcium channel (CACN) subunit α2δ3 knockout mice: Consequences of sensory cross-modal activation. Behav Brain Res. 364:393-402

Cheng, SH., Penninger, JM., Ferrick, DA (...) Wallace, VA., Mak, TW. (1991). Biology of murine gamma delta T cells. Crit Rev Immunol. 11(3-4):145-66

Kiechl, S., Wittmann, J., Giaccari, A (...) Willeit, J., Schett, G. (2013). Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med. 19(3):358-63

Tanemura, S., Momose, H., Shimizu, N (...) Katada, T., Nishina, H. (2009). Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. J Biochem. 145(3):345-54

Salewskij, K., Penninger, JM. (2023). Blood Vessel Organoids for Development and Disease. Circ Res. 132(4):498-510

Qi, Y., Tian, X., Liu, J (...) Carmeliet, P., Li, S. (2012). Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. J Cell Biol. 198(1):103-14

Osawa, M., Tong, KI., Lilliehook, C (...) Ikura, M., Ames, JB. (2001). Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3. J Biol Chem. 276(44):41005-13

Pietrocola, F., Pol, J., Vacchelli, E (...) Penninger, JM., Kroemer, G. (2016). Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance. Cancer Cell. 30(1):147-160

Pummerer, CL., Grässl, G., Sailer, M (...) Penninger, JM., Neu, N. (1996). Cardiac myosin-induced myocarditis: target recognition by autoreactive T cells requires prior activation of cardiac interstitial cells. Lab Invest. 74(5):845-52

Zhang, ZZ., Shang, QH., Jin, HY (...) Penninger, JM., Zhong, JC. (2013). Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med. 11:229

Haubner, BJ., Schuetz, T., Penninger, JM. (2018). Cardiac regeneration in a newborn: what does this mean for future cardiac repair research? Expert Rev Cardiovasc Ther. 16(3):155-157

Wang, J., An, M., Haubner, BJ., Penninger, JM. (2022). Cardiac regeneration: Options for repairing the injured heart. Front Cardiovasc Med. 9:981982

Oudit, GY., Penninger, JM. (2009). Cardiac regulation by phosphoinositide 3-kinases and PTEN. Cardiovasc Res. 82(2):250-60

Kerfant, BG., Gidrewicz, D., Sun, H (...) Penninger, JM., Backx, PH. (2005). Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circ Res. 96(10):1079-86

Sun, Y., Guo, F., Zou, Z (...) Penninger, JM., Jiang, C. (2015). Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. Part Fibre Toxicol. 12:4

Feraud, O., Debili, N., Penninger, JM., Kroemer, G. (2007). Cavitation of embryoid bodies requires optimal oxidative phosphorylation and AIF. Cell Death Differ. 14(2):385-7

Griffiths, EK., Sanchez, O., Mill, P (...) Hui, CC., Penninger, JM. (2003). Cbl-3-deficient mice exhibit normal epithelial development. Mol Cell Biol. 23(21):7708-18

Keane, MM., Ettenberg, SA., Nau, MM (...) Penninger, J., Lipkowitz, S. (1999). cbl-3: a new mammalian cbl family protein. Oncogene. 18(22):3365-75

Singh, TP., Vieyra-Garcia, PA., Wagner, K., Penninger, J., Wolf, P. (2018). Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature. Cell Death Dis. 9(8):835

Paolino, M., Penninger, JM. (2010). Cbl-b in T-cell activation. Semin Immunopathol. 32(2):137-48

Krawczyk, C., Bachmaier, K., Sasaki, T (...) Alt, FW., Penninger, JM. (2000). Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 13(4):463-73

Badger-Brown, KM., Gillis, LC., Bailey, ML., Penninger, JM., Barber, DL. (2013). CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing. Leukemia. 27(5):1146-54

Oh, SY., Park, JU., Zheng, T (...) Penninger, J., Zhu, Z. (2011). Cbl-b regulates airway mucosal tolerance to aeroallergen. Clin Exp Allergy. 41(3):434-42

Oliveira-dos-Santos, AJ., Ho, A., Tada, Y (...) Mak, TW., Penninger, JM. (1999). CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis. J Immunol. 162(8):4490-5

Nunes-Souza, V., Alenina, N., Qadri, F (...) Bader, M., Rabelo, LA. (2016). CD36/Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice. Oxid Med Cell Longev. 2016:6487509

Wallace, VA., Rahemtulla, A., Timms, E., Penninger, J., Mak, TW. (1992). CD4 expression is differentially required for deletion of MLS-1a-reactive T cells. J Exp Med. 176(5):1459-63

Wallace, VA., Penninger, J., Mak, TW. (1993). CD4, CD8 and tyrosine kinases in thymic selection. Curr Opin Immunol. 5(2):235-40

Irie-Sasaki, J., Sasaki, T., Matsumoto, W (...) Rothstein, DM., Penninger, JM. (2001). CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 409(6818):349-54

Irie-Sasaki, J., Sasaki, T., Penninger, JM. (2003). CD45 regulated signaling pathways. Curr Top Med Chem. 3(7):783-96

Penninger, JM., Irie-Sasaki, J., Sasaki, T., Oliveira-dos-Santos, AJ. (2001). CD45: new jobs for an old acquaintance. Nat Immunol. 2(5):389-96

Wallace, VA., Fung-Leung, WP., Timms, E (...) Penninger, J., Mak, TW. (1992). CD45RA and CD45RBhigh expression induced by thymic selection events. J Exp Med. 176(6):1657-63

Hara, H., Ishihara, C., Takeuchi, A (...) Yoshida, H., Saito, T. (2008). Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9. J Immunol. 181(2):918-30

Penninger, JM., Pummerer, C., Liu, P., Neu, N., Bachmaier, K. (1997). Cellular and molecular mechanisms of murine autoimmune myocarditis. APMIS. 105(1):1-13

Hanada, R., Leibbrandt, A., Hanada, T (...) Narumiya, S., Penninger, JM. (2009). Central control of fever and female body temperature by RANKL/RANK. Nature. 462(7272):505-9

Lee, NJ., Clarke, IM., Enriquez, RF (...) Baldock, PA., Herzog, H. (2018). Central RANK signalling in NPY neurons alters bone mass in male mice. Neuropeptides. 68:75-83

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Nakashima T., Penninger, JM. (2006). Chemotactic regulation of cancer cell migration and bone metastases by RANKL. Experimental Medicine. 24:1777-80

Rieker, T., Penninger, J., Romani, N., Wick, G. (1995). Chicken thymic nurse cells: an overview. Dev Comp Immunol. 19(4):281-9

Bachmaier, K., Penninger, JM. (2005). Chlamydia and antigenic mimicry. Curr Top Microbiol Immunol. 296:153-63

Bachmaier, K., Neu, N., de la Maza, LM (...) Hessel, A., Penninger, JM. (1999). Chlamydia infections and heart disease linked through antigenic mimicry. Science. 283(5406):1335-9

Greenblatt, MB., Park, KH., Oh, H (...) Ghosh, S., Shim, JH. (2015). CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts. J Exp Med. 212(8):1283-301

Monteil, V., Eaton, B., Postnikova, E (...) Wirnsberger, G., Penninger, JM. (2022). Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants. EMBO Mol Med. :e15230

Wirnsberger, G., Monteil, V., Eaton, B (...) Mirazimi, A., Penninger, JM. (2021). Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants. bioRxiv.

Fujinami, H., Shiraishi, H., Hada, K (...) Mimata, H., Hanada, T. (2020). CLP1 acts as the main RNA kinase in mice. Biochem Biophys Res Commun.

Weitzer, S., Hanada, T., Penninger, JM., Martinez, J. (2015). CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders. Wiley Interdiscip Rev RNA. 6(1):47-63

Hanada, T., Weitzer, S., Mair, B (...) Martinez, J., Penninger, JM. (2013). CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 495(7442):474-80

Sasaki, T., Irie-Sasaki, J., Horie, Y (...) Tsao, M., Penninger, JM. (2000). Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Nature. 406(6798):897-902

Heindl-Erdmann, C., Axmann, R., Kreitz, S (...) Brune, K., Hess, A. (2010). Combining functional magnetic resonance imaging with mouse genomics: new options in pain research. Neuroreport. 21(1):29-33

Griffiths, EK., Penninger, JM. (2002). Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr Opin Immunol. 14(3):317-22

Kawahara, R., Chernykh, A., Alagesan, K (...) Packer, NH., Thaysen-Andersen, M. (2021). Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. Nat Methods. 18(11):1304-1316

Stadlmann, J., Taubenschmid, J., Wenzel, D (...) Mechtler, K., Penninger, JM. (2017). Comparative glycoproteomics of stem cells identifies new players in ricin toxicity. Nature. 549(7673):538-542

Ctortecka, C., Krššáková, G., Stejskal, K (...) Mechtler, K., Stadlmann, J. (2021). Comparative proteome signatures of trace samples by multiplexed Data-Independent Acquisition. Mol Cell Proteomics. :100177

Haubner, BJ., Adamowicz-Brice, M., Khadayate, S (...) Aitman, T., Penninger, JM. (2012). Complete cardiac regeneration in a mouse model of myocardial infarction. Aging (Albany NY). 4(12):966-77

Tsvetkov, P., Mendillo, ML., Zhao, J (...) Santagata, S., Lindquist, S. (2015). Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife. 4

Neely, GG., Rao, S., Costigan, M (...) Woolf, CJ., Penninger, JM. (2012). Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet. 8(12):e1003071

Rath, M., Schwefel, K., Malinverno, M (...) Dejana, E., Felbor, U. (2022). Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells. Cell Mol Life Sci. 79(6):340

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Winchester, CL., Ohzeki, H., Vouyiouklis, DA (...) Pratt, JA., Morris, BJ. (2012). Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia. Hum Mol Genet. 21(22):4910-21

Matsumoto, G., Nghiem, MP., Nozaki, N., Schmits, R., Penninger, JM. (1998). Cooperation between CD44 and LFA-1/CD11a adhesion receptors in lymphokine-activated killer cell cytotoxicity. J Immunol. 160(12):5781-9

Kaminski, S., Hermann-Kleiter, N., Meisel, M (...) Penninger, JM., Baier, G. (2011). Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells. J Autoimmun. 37(3):198-208

Andergassen, D., Muckenhuber, M., Bammer, PC (...) Pauler, FM., Hudson, QJ. (2020). Correction: The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes. PLoS Genet. 16(10):e1009151

Ikebuchi, Y., Aoki, S., Honma, M (...) Aoki, K., Suzuki, H. (2018). Coupling of bone resorption and formation by RANKL reverse signalling. Nature. 561(7722):195-200

Monteil, VM., Wright, SC., Dyczynski, M (...) Penninger, JM., Mirazimi, A. (2024). Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells. Nat Microbiol.

Reif, K., Okkenhaug, K., Sasaki, T (...) Vanhaesebroeck, B., Cyster, JG. (2004). Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol. 173(4):2236-40

Ichikawa, A., Kuba, K., Morita, M (...) Slutsky, AS., Imai, Y. (2013). CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med. 187(1):65-77

Kurrer, MO., Kopf, M., Penninger, J., Eriksson, U. (2002). Cytokines that regulate autoimmune myocarditis. Swiss Med Wkly. 132(29-30):408-13

Olie, CS., van der Wal, E., Cikes, D (...) Kessler, BM., Raz, V. (2020). Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability. Sci Rep. 10(1):17621

Reich, HN., Oudit, GY., Penninger, JM., Scholey, JW., Herzenberg, AM. (2008). Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int. 74(12):1610-6

Singer, D., Camargo, SM., Ramadan, T (...) Penninger, JM., Verrey, F. (2012). Defective intestinal amino acid absorption in Ace2 null mice. Am J Physiol Gastrointest Liver Physiol. 303(6):G686-95

Nishina, H., Vaz, C., Billia, P (...) Woodgett, JR., Penninger, JM. (1999). Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development. 126(3):505-16

Séverin, S., Gratacap, MP., Lenain, N (...) Plantavid, M., Payrastre, B. (2007). Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth. J Clin Invest. 117(4):944-52

Eriksson, U., Ricci, R., Hunziker, L (...) Kopf, M., Penninger, JM. (2003). Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med. 9(12):1484-90

Alnaeeli, M., Park, J., Mahamed, D., Penninger, JM., Teng, YT. (2007). Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss. J Bone Miner Res. 22(6):775-80

Klempin, F., Mosienko, V., Matthes, S (...) Santos, RAS., Alenina, N. (2018). Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response. Cell Mol Life Sci. 75(19):3625-3634

Elling, U., Woods, M., Forment, JV (...) Penninger, JM., Balmus, G. (2019). Derivation and maintenance of mouse haploid embryonic stem cells. Nat Protoc. 14(7):1991-2014

Perlot, T., Penninger, JM. (2012). Development and function of murine B cells lacking RANK. J Immunol. 188(3):1201-5

Shoemaker, RH., Panettieri, RA., Libutti, SK (...) Penninger, JM., Wirnsberger, G. (2021). Development of a novel, pan-variant aerosol intervention for COVID-19. bioRxiv.

Shoemaker, RH., Panettieri, RA., Libutti, SK (...) Penninger, JM., Wirnsberger, G. (2022). Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer. PLoS One. 17(7):e0271066

Fedecka-Bruner, B., Penninger, J., Vaigot, P (...) Martínez, C., Kroemer, G. (1991). Developmental expression of IL-2-receptor light chain (CD25) in the chicken embryo. Dev Immunol. 1(3):237-42

Desanti, GE., Cowan, JE., Baik, S (...) Jenkinson, WE., Anderson, G. (2012). Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla. J Immunol. 189(12):5519-26

Wilson, LD., Ross, SA., Lepore, DA (...) Penninger, JM., Thomas, PQ. (2005). Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary. Gene Expr Patterns. 5(3):305-11

Cheng, HY., Obrietan, K., Cain, SW (...) Ralph, MR., Penninger, JM. (2004). Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron. 43(5):715-28

Kishimoto, H., Nakagawa, K., Watanabe, T (...) Nishina, H., Katada, T. (2003). Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem. 278(19):16595-601

Krawczyk, CM., Jones, RG., Atfield, A (...) Ohashi, PS., Penninger, JM. (2005). Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b. J Immunol. 174(3):1472-8

Anglesio, MS., Evdokimova, V., Melnyk, N (...) Penninger, J., Sorensen, PH. (2004). Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. Hum Mol Genet. 13(18):2061-74

Hakem, R., Hakem, A., Duncan, GS (...) Penninger, JM., Mak, TW. (1998). Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 94(3):339-52

Molina, TJ., Perrot, JY., Penninger, J (...) Mak, TW., Diebold, J. (1998). Differential requirement for p56lck in fetal and adult thymopoiesis. J Immunol. 160(8):3828-34

Schuetz T, Kuehn B, Penninger JM, Haubner BJ (2015). Direct comparison of ischemic- vs. cryoinjury in the neonatal mouse heart. Wiener Klinische Wochenschrift. (127):9-10

Grabner, B., Schramek, D., Mueller, KM (...) Popper, H., Casanova, E. (2015). Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun. 6:6285

Blaas, L., Kornfeld, JW., Schramek, D (...) Trauner, M., Casanova, E. (2010). Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology. 51(4):1319-26

Cheung, EC., Joza, N., Steenaart, NA (...) Penninger, JM., Slack, RS. (2006). Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J. 25(17):4061-73

Ricci, R., Eriksson, U., Oudit, GY (...) Penninger, JM., Wagner, EF. (2005). Distinct functions of junD in cardiac hypertrophy and heart failure. Genes Dev. 19(2):208-13

Garabelli, PJ., Modrall, JG., Penninger, JM., Ferrario, CM., Chappell, MC. (2008). Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Exp Physiol. 93(5):613-21

Valdés, G., Neves, LA., Anton, L (...) Penninger, J., Brosnihan, KB. (2006). Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies. Placenta. 27(2-3):200-7

Penninger, J.M. (2008). Do genes dream? In: Identitaet(en). Ed. GLOBArt. Springer.

Loeffler, M., Daugas, E., Susin, SA (...) Penninger, JM., Kroemer, G. (2001). Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J. 15(3):758-67

Cheng, HY., Laviolette, SR., van der Kooy, D., Penninger, JM. (2004). DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine. Eur J Neurosci. 19(11):3033-41

Cheng, HY., Pitcher, GM., Laviolette, SR (...) Salter, MW., Penninger, JM. (2002). DREAM is a critical transcriptional repressor for pain modulation. Cell. 108(1):31-43

Cheng, H-Y.M, Penninger, JM. (2006). Dream/KchIP/ Calsenilin: a multifunctional player in health and disease. In Neuronal Calcium Sensor Proteins (Philippov, Koch, eds.); Nova Science Publishers. :245-270

Cheng, HY., Penninger, JM. (2004). DREAMing about arthritic pain. Ann Rheum Dis. 63 Suppl 2:ii72-ii75

Pospisilik, JA., Schramek, D., Schnidar, H (...) Esterbauer, H., Penninger, JM. (2010). Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell. 140(1):148-60

Ni, J., Yang, F., Huang, XR (...) Yu, XQ., Lan, HY. (2020). Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy. J Cell Mol Med. 24(22):13093-13103

Appelberg, S., Gupta, S., Svensson Akusjärvi, S (...) Mirazimi, A., Neogi, U. (2020). Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Emerg Microbes Infect. 9(1):1748-1760

Guo, H., Qiao, G., Ying, H (...) Langdon, WY., Zhang, J. (2012). E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Rep. 1(5):472-82

Qiao, G., Ying, H., Zhao, Y (...) Langdon, WY., Zhang, J. (2014). E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Rep. 6(4):709-23

Paolino, M., Penninger, JM. (2009). E3 ubiquitin ligases in T-cell tolerance. Eur J Immunol. 39(9):2337-44

Motta-Santos, D., Dos Santos, RA., Oliveira, M (...) Alenina, N., Bader, M. (2016). Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise. Hypertens Res. 39(7):506-12

Sato, T., Sato, C., Kadowaki, A (...) Imai, Y., Kuba, K. (2017). ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. Cardiovasc Res. 113(7):760-769

Liu, Q., Telezhkin, V., Jiang, W (...) Penninger, J., Song, B. (2023). Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation. Cell Biosci. 13(1):4

Zhao, M., Song, B., Pu, J (...) McCaig, CD., Penninger, JM. (2006). Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 442(7101):457-60

Opavsky, MA., Martino, T., Rabinovitch, M (...) Chan, J., Liu, PP. (2002). Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis. J Clin Invest. 109(12):1561-9

Brosnihan, KB., Neves, LA., Joyner, J (...) Penninger, J., Ferrario, CM. (2003). Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy. Hypertension. 42(4):749-53

Bodiga, S., Zhong, JC., Wang, W (...) Kassiri, Z., Oudit, GY. (2011). Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. Cardiovasc Res. 91(1):151-61

Meixner, A., Zenz, R., Schonthaler, HB (...) Penninger, JM., Wagner, EF. (2008). Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation. Nat Cell Biol. 10(8):1003-11

Loser, K., Mehling, A., Loeser, S (...) Penninger, JM., Beissert, S. (2006). Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med. 12(12):1372-9

Hasan Ali, O., Bomze, D., Risch, L (...) Penninger, JM., Flatz, L. (2021). Erratum to: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies. Clin Infect Dis.

Leibbrandt, A., Penninger, JM. (2009). ESCI award lecture: from a little mouse to rationale medicine for bone loss. Eur J Clin Invest. 39(10):842-50

Danilczyk, U., Sarao, R., Remy, C (...) Wagner, CA., Penninger, JM. (2006). Essential role for collectrin in renal amino acid transport. Nature. 444(7122):1088-91

Paolino, M., Thien, CB., Gruber, T (...) Langdon, WY., Penninger, JM. (2011). Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions. J Immunol. 186(4):2138-47

Crackower, MA., Kolas, NK., Noguchi, J (...) Moens, PB., Penninger, JM. (2003). Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science. 300(5623):1291-5

Matsumoto, G., Kubota, E., Omi, Y., Lee, U., Penninger, JM. (2004). Essential role of LFA-1 in activating Th2-like responses by alpha-galactosylceramide-activated NKT cells. J Immunol. 173(8):4976-84

Matsumoto, G., Tsunematsu, S., Tsukinoki, K (...) Shindo, J., Penninger, JM. (2002). Essential role of the adhesion receptor LFA-1 for T cell-dependent fulminant hepatitis. J Immunol. 169(12):7087-96

Jeon, MS., Atfield, A., Venuprasad, K (...) Liu, YC., Penninger, JM. (2004). Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity. 21(2):167-77

Joza, N., Susin, SA., Daugas, E (...) Kroemer, G., Penninger, JM. (2001). Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 410(6828):549-54

Galluzzi, L., Bravo-San Pedro, JM., Vitale, I (...) Melino, G., Kroemer, G. (2015). Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 22(1):58-73

Nakashima, T., Hayashi, M., Fukunaga, T (...) Penninger, JM., Takayanagi, H. (2011). Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 17(10):1231-4

Batlle, D., Monteil, V., Garreta, E (...) Bader, M., Penninger, JM. (2022). Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity. Cell. 185(11):1837-1839

Vorbach, C., Capecchi, MR., Penninger, JM. (2006). Evolution of the mammary gland from the innate immune system? Bioessays. 28(6):606-16

Koh, DR., Ho, A., Rahemtulla, A., Penninger, J., Mak, TW. (1994). Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells. Eur J Immunol. 24(9):2250-3

Lempradl, A., Pospisilik, JA., Penninger, JM. (2015). Exploring the emerging complexity in transcriptional regulation of energy homeostasis. Nat Rev Genet. 16(11):665-81

Malik, B., Vokic, I., Mohr, T (...) Sibilia, M., Csiszar, A. (2023). FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice. EMBO Mol Med. 15(7):e16758

Ajoolabady, A., Aslkhodapasandhokmabad, H., Libby, P (...) Kroemer, G., Ren, J. (2021). Ferritinophagy and ferroptosis in the management of metabolic diseases. Trends Endocrinol Metab. 32(7):444-462

Fell, CW., Hagelkruys, A., Cicvaric, A (...) Penninger, JM., Nagy, V. (2022). FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder. EMBO Mol Med. 14(9):e15829

Nitta, T., Tsutsumi, M., Nitta, S (...) Penninger, JM., Takayanagi, H. (2020). Fibroblasts as a source of self-antigens for central immune tolerance. Nat Immunol. 21(10):1172-1180

Zhu, R., Canena, D., Sikora, M (...) Hummer, G., Hinterdorfer, P. (2022). Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nat Commun. 13(1):7926

Elling, U., Taubenschmid, J., Wirnsberger, G (...) Stark, A., Penninger, JM. (2011). Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell. 9(6):563-74

Arai, A., Mizoguchi, T., Harada, S (...) Udagawa, N., Takahashi, N. (2012). Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment. J Cell Sci. 125(Pt 12):2910-7

Cronin, SJ., Penninger, JM. (2007). From T-cell activation signals to signaling control of anti-cancer immunity. Immunol Rev. 220:151-68

Schneider, C., Nobs, SP., Heer, AK (...) Siggs, OM., Kopf, M. (2017). Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection. J Leukoc Biol. 101(2):367-376

Sasaki, T., Irie-Sasaki, J., Jones, RG (...) Suzuki, A., Penninger, JM. (2000). Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science. 287(5455):1040-6

Teng, YT., Nguyen, H., Gao, X (...) Ellen, RP., Penninger, JM. (2000). Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest. 106(6):R59-67

Haubner, BJ., Schneider, J., Schweigmann, U (...) Stein, JI., Penninger, JM. (2016). Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction. Circ Res. 118(2):216-21

Mahamed, DA., Marleau, A., Alnaeeli, M (...) Penninger, JM., Teng, YT. (2005). G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice. Diabetes. 54(5):1477-86

Heier, C., Radner, FP., Moustafa, T (...) Zimmermann, R., Zechner, R. (2015). G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis. J Biol Chem. 290(43):26141-50

Lee, AW., Mao, Y., Penninger, JM., Yu, S. (2011). Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development. Mol Cell Biol. 31(22):4563-81

Wöhrle, FU., Halbach, S., Aumann, K (...) Daly, RJ., Brummer, T. (2013). Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors. Leukemia. 27(1):118-29

Wimmer, RA., Leopoldi, A., Aichinger, M., Kerjaschki, D., Penninger, JM. (2019). Generation of blood vessel organoids from human pluripotent stem cells. Nat Protoc. 14(11):3082-3100

Frenz-Wiessner, S., Fairley, SD., Buser, M (...) Marr, C., Klein, C. (2024). Generation of complex bone marrow organoids from human induced pluripotent stem cells. Nat Methods.

Werschler, N., Penninger, J. (2023). Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells. J Vis Exp. (191)

Bachmaier, K., Neu, N., Yeung, RS (...) Liu, P., Penninger, JM. (1999). Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Circulation. 99(14):1885-91

Joza, N., Kroemer, G., Penninger, JM. (2002). Genetic analysis of the mammalian cell death machinery. Trends Genet. 18(3):142-9

Rabelo, LA., Todiras, M., Nunes-Souza, V (...) Santos, RA., Alenina, N. (2016). Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress. PLoS One. 11(4):e0150255

Dufresne, SS., Boulanger-Piette, A., Bossé, S (...) Russell Tupling, A., Frenette, J. (2018). Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy. Acta Neuropathol Commun. 6(1):31

Wenzel, D., Bayerl, J., Nyström, A (...) Meixner, A., Penninger, JM. (2014). Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa. Sci Transl Med. 6(264):264ra165

Yeung, RS., Penninger, J., Mak, TW. (1993). Genetically modified animals and immunodeficiency. Curr Opin Immunol. 5(4):585-94

Elling, U., Penninger, JM. (2014). Genome wide functional genetics in haploid cells. FEBS Lett. 588(15):2415-21

Cronin, SJ., Nehme, NT., Limmer, S (...) Ferrandon, D., Penninger, JM. (2009). Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science. 325(5938):340-3

Tran, CW., Saibil, SD., Le Bihan, T (...) Mak, TW., Ohashi, PS. (2017). Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. J Immunol. 199(12):4056-4065

Cikes, D., Leutner, M., Cronin, SJF (...) Orthofer, M., Penninger, JM. (2024). Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism. Nat Aging. 4(1):80-94

Klionsky, DJ., Abdelmohsen, K., Abe, A (...) Zorzano, A., Zughaier, SM. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222

Galluzzi, L., Aaronson, SA., Abrams, J (...) Zhivotovsky, B., Kroemer, G. (2009). Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 16(8):1093-107

Turgu, B., Zhang, F., El-Naggar, A (...) Hughes, CS., Sorensen, PH. (2021). HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner. Oncogene. 40(11):1988-2001

Daugaard, M., Nitsch, R., Razaghi, B (...) Penninger, JM., Sorensen, PH. (2013). Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nat Commun. 4:2180

Nagy, V., Hollstein, R., Pai, TP (...) Kaiser, FJ., Penninger, JM. (2019). HACE1 deficiency leads to structural and functional neurodevelopmental defects. Neurol Genet. 5(3):e330

Kogler, M., Tortola, L., Negri, GL (...) Sorensen, PH., Penninger, JM. (2020). HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases. Cancer Res. 80(14):3009-3022

Rotblat, B., Southwell, AL., Ehrnhoefer, DE (...) Hayden, MR., Sorensen, PH. (2014). HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. Proc Natl Acad Sci U S A. 111(8):3032-7

Zhang, L., Chen, X., Sharma, P (...) Brumell, JH., Liu, PP. (2014). HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat Commun. 5:3430

Ravagnan, L., Gurbuxani, S., Susin, SA (...) Garrido, C., Kroemer, G. (2001). Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol. 3(9):839-43

Teperino, R., Amann, S., Bayer, M (...) Pospisilik, JA., Esterbauer, H. (2012). Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell. 151(2):414-26

Mischkulnig, M., Kiesel, B., Lötsch, D (...) Widhalm, G., Erhart, F. (2021). Heme Biosynthesis mRNA Expression Signature: Towards a Novel Prognostic Biomarker in Patients with Diffusely Infiltrating Gliomas. Cancers (Basel). 13(4)

Ooshio, T., Yamamoto, M., Fujii, K (...) Nishina, H., Nishikawa, Y. (2021). Hepatocyte Mitogen-Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma Following Injury in Mice. Hepatology. 73(6):2510-2526

Wang, W., Patel, VB., Parajuli, N (...) Penninger, JM., Oudit, GY. (2014). Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease. J Mol Med (Berl). 92(8):847-58

Köcher, T., Pichler, P., Schutzbier, M (...) Penninger, JM., Mechtler, K. (2009). High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all. J Proteome Res. 8(10):4743-52

Wimmer, RA., Leopoldi, A., Aichinger, M (...) Kerjaschki, D., Penninger, JM. (2019). Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 565(7740):505-510

Yeung, RS., Penninger, JM., Kündig, T (...) Kroemer, G., Mak, TW. (1996). Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen-induced septic shock. Eur J Immunol. 26(5):1074-82

Yeung, RS., Penninger, JM., Kündig, TM (...) Ohashi, PS., Mak, TW. (1994). Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function. J Exp Med. 180(5):1911-20

Karaca, E., Weitzer, S., Pehlivan, D (...) Penninger, JM., Lupski, JR. (2014). Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function. Cell. 157(3):636-50

Oudit, GY., Liu, GC., Zhong, J (...) Kassiri, Z., Scholey, JW. (2010). Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes. 59(2):529-38

Zoufaly, A., Poglitsch, M., Aberle, JH (...) Slutsky, AS., Penninger, JM. (2020). Human recombinant soluble ACE2 in severe COVID-19. Lancet Respir Med. 8(11):1154-1158

Monteil, V., Dyczynski, M., Lauschke, VM (...) Penninger, JM., Mirazimi, A. (2021). Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection. EMBO Mol Med. 13(1):e13426

Heximer, SP., Knutsen, RH., Sun, X (...) Mecham, RP., Blumer, KJ. (2003). Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest. 111(8):1259

Danilczyk, U., Penninger, J. (2004). Hypertension with a grain of salt. Nat Med. 10(11):1163-4

Tafuri, A., Shahinian, A., Bladt, F (...) Ohashi, PS., Mak, TW. (2001). ICOS is essential for effective T-helper-cell responses. Nature. 409(6816):105-9

Nagatake, T., Fukuyama, S., Kim, DY (...) Kunisawa, J., Kiyono, H. (2009). Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med. 206(11):2351-64

del Toro, R., Prahst, C., Mathivet, T (...) Penninger, J., Eichmann, A. (2010). Identification and functional analysis of endothelial tip cell-enriched genes. Blood. 116(19):4025-33

Orthofer, M., Valsesia, A., Mägi, R (...) Gheldof, N., Penninger, JM. (2020). Identification of ALK in Thinness. Cell. 181(6):1246-1262.e22

Pummerer, CL., Luze, K., Grässl, G (...) Penninger, JM., Neu, N. (1996). Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice. J Clin Invest. 97(9):2057-62

Monteil, V., Kwon, H., John, L (...) Penninger, JM., Mirazimi, A. (2023). Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections. Nat Commun. 14(1):6785

Mizoguchi, T., Muto, A., Udagawa, N (...) Ito, M., Takahashi, N. (2009). Identification of cell cycle-arrested quiescent osteoclast precursors in vivo. J Cell Biol. 184(4):541-54

Akiyama, N., Takizawa, N., Miyauchi, M (...) Inoue, J., Akiyama, T. (2016). Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. J Exp Med. 213(8):1441-58

Hoffmann, D., Mereiter, S., Jin Oh, Y (...) Hinterdorfer, P., Penninger, JM. (2021). Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites. EMBO J. :e108375

Imai, Y., Kuba, K., Neely, GG (...) Binder, CJ., Penninger, JM. (2008). Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 133(2):235-49

Nagashima, K., Sawa, S., Nitta, T (...) Nakashima, T., Takayanagi, H. (2017). Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nat Immunol. 18(6):675-682

Jun, JE., Wilson, LE., Vinuesa, CG (...) Nelms, KA., Goodnow, CC. (2003). Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity. 18(6):751-62

Suzuki, N., Chen, NJ., Millar, DG (...) Ohashi, PS., Yeh, WC. (2003). IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. J Immunol. 170(8):4031-5

Marra, LE., Zhang, ZX., Joe, B (...) Penninger, J., Zhang, L. (2004). IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. J Immunol. 172(2):1028-35

Suzuki, N., Suzuki, S., Eriksson, U (...) Saito, T., Yeh, WC. (2003). IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. J Immunol. 171(11):6065-71

Alnaeeli, M., Penninger, JM., Teng, YT. (2006). Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. J Immunol. 177(5):3314-26

Liu, YC., Penninger, J., Karin, M. (2005). Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol. 5(12):941-52

Peña Silva, RA., Chu, Y., Miller, JD (...) Faraci, FM., Heistad, DD. (2012). Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke. 43(12):3358-63

Nishina, H., Bachmann, M., Oliveira-dos-Santos, AJ (...) Ohashi, PS., Penninger, JM. (1997). Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J Exp Med. 186(6):941-53

Kuba, K., Zhang, L., Imai, Y (...) Liu, PP., Penninger, JM. (2007). Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res. 101(4):e32-42

Amakawa, R., Hakem, A., Kundig, TM (...) Penninger, JM., Mak, TW. (1996). Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell. 84(4):551-62

Wada, T., Nakagawa, K., Watanabe, T (...) Nishina, H., Katada, T. (2001). Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation. J Biol Chem. 276(33):30892-7

Raberger, J., Boucheron, N., Sakaguchi, S., Penninger, JM., Ellmeier, W. (2008). Impaired T-cell development in the absence of Vav1 and Itk. Eur J Immunol. 38(12):3530-42

Nishina, H., Radvanyi, L., Raju, K (...) Kozieradzki, I., Penninger, JM. (1998). Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4. J Immunol. 161(7):3416-20

Cronin, SJF., Davidow, LS., Arvanites, AC (...) Penninger, JM., Woolf, CJ. (2023). Implementation of a Drug Screening Platform to Target<i>Gch1</i> Expression in Injured Mouse Dorsal Root Ganglion Neurons. Bio Protoc. 13(9):e4666

Kulinski, TM., Casari, MR., Guenzl, PM (...) Barlow, DP., Hudson, QJ. (2015). Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 402(2):291-305

Stadlmann, J., Hudecz, O., Krššáková, G (...) Jacobs, P., Mechtler, K. (2019). Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography. Anal Chem. 91(22):14203-14207

Rieker, T., Penninger, J., Hala, K., Cooper, MD., Wick, G. (1993). In situ analyses of in ovo graft-vs.-host reaction induced by thymic nurse cell lymphocytes. Eur J Immunol. 23(4):904-10

Zuber, AM., Singer, D., Penninger, JM., Rossier, BC., Firsov, D. (2007). Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice. J Am Soc Nephrol. 18(6):1672-8

Penninger, JM., Bachmaier, K. (2002). Infections and the immune response to cardiac antigens. Book chapter. Epitope recognition since Landsteiner's discovery - 100 years since the discovery of human blood groups (Eibl, M., Mayr, WR., Thorbecke, GJ., eds.). :103-17

Onodera, Y., Liang, J., Li, Y (...) Mubareka, S., Zhang, H. (2023). Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern. iScience. 26(8):107470

Wirnsberger, G., Zwolanek, F., Asaoka, T (...) Kuchler, K., Penninger, JM. (2016). Inhibition of CBLB protects from lethal Candida albicans sepsis. Nat Med. 22(8):915-23

Gómez-Aleza, C., Nguyen, B., Yoldi, G (...) Sotiriou, C., González-Suárez, E. (2020). Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells. Nat Commun. 11(1):6335

Monteil, V., Kwon, H., Prado, P (...) Mirazimi, A., Penninger, JM. (2020). Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell. 181(4):905-913.e7

Guerrini, MM., Okamoto, K., Komatsu, N (...) Nakashima, T., Takayanagi, H. (2015). Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System. Immunity. 43(6):1174-85

Bachmaier, K., Neu, N., Pummerer, C (...) Matsuyama, T., Penninger, JM. (1997). iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1. Circulation. 96(2):585-91

Sun, H., Kerfant, BG., Zhao, D (...) Penninger, JM., Backx, PH. (2006). Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. Circ Res. 98(11):1390-7

Iwamoto, Y., Nishikawa, K., Imai, R (...) Inohara, H., Ishii, M. (2016). Intercellular Communication between Keratinocytes and Fibroblasts Induces Local Osteoclast Differentiation: a Mechanism Underlying Cholesteatoma-Induced Bone Destruction. Mol Cell Biol. 36(11):1610-20

Penninger, J., Klima, J., Kroemer, G (...) Hala, K., Wick, G. (1989). Intra-thymic nurse cell lymphocytes can induce a graft-versus-host reaction with high efficiency. Dev Comp Immunol. 13(4):313-27

Yum, HK., Arcaroli, J., Kupfner, J (...) Park, JS., Abraham, E. (2001). Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. J Immunol. 167(11):6601-8

Kimura, T., Nakayama, K., Penninger, J (...) Vilcek, J., Mak, TW. (1994). Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science. 264(5167):1921-4

Boztug, K., Järvinen, PM., Salzer, E (...) Donadieu, J., Klein, C. (2014). JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Nat Genet. 46(9):1021-7

Wirnsberger, G., Zwolanek, F., Stadlmann, J (...) Elling, U., Penninger, JM. (2014). Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Nat Genet. 46(9):1028-33

Stebbing, J., Sánchez Nievas, G., Falcone, M (...) Abizanda, P., Lauschke, VM. (2021). JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. Sci Adv. 7(1)

Openshaw, RL., Kwon, J., McColl, A (...) Pratt, JA., Morris, BJ. (2019). JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. J Neuroinflammation. 16(1):18

Meixner, A., Karreth, F., Kenner, L., Penninger, JM., Wagner, EF. (2010). Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death Differ. 17(9):1409-19

Eriksson, U., Danilczyk, U., Penninger, JM. (2002). Just the beginning: novel functions for angiotensin-converting enzymes. Curr Biol. 12(21):R745-52

Nakajima, KI., Zhu, K., Sun, YH (...) Penninger, JM., Zhao, M. (2015). KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun. 6:8532

Mak, TW., Penninger, JM., Ohashi, PS. (2001). Knockout mice: a paradigm shift in modern immunology. Nat Rev Immunol. 1(1):11-9

Fontán-Lozano, A., Romero-Granados, R., del-Pozo-Martín, Y (...) Penninger, JM., Carrión, AM. (2009). Lack of DREAM protein enhances learning and memory and slows brain aging. Curr Biol. 19(1):54-60

Kuba, K., Imai, Y., Rao, S., Jiang, C., Penninger, JM. (2006). Lessons from SARS: control of acute lung failure by the SARS receptor ACE2. J Mol Med (Berl). 84(10):814-20

Liu, L., Puri, KD., Penninger, JM., Kubes, P. (2007). Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood. 110(4):1191-8

Sasaki, F., Koga, T., Ohba, M (...) Sonoda, KH., Yokomizo, T. (2018). Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models. JCI Insight. 3(18)

Luo, J., Yang, Z., Ma, Y (...) Xiao, J., Liu, M. (2016). LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nat Med. 22(5):539-46

Muto, A., Mizoguchi, T., Udagawa, N (...) Noguchi, T., Takahashi, N. (2011). Lineage-committed osteoclast precursors circulate in blood and settle down into bone. J Bone Miner Res. 26(12):2978-90

Penninger, JM., Wallace, VA., Molina, T., Mak, TW. (1996). Lineage-specific control of superantigen-induced cell death by the protein tyrosine kinase p56(lck). J Immunol. 157(12):5359-66

Raith, M., Valencia, RG., Fischer, I (...) Rezniczek, GA., Wiche, G. (2013). Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers. Skelet Muscle. 3(1):14

Brown, D., Yu, BD., Joza, N (...) Penninger, JM., Martin, GR. (2006). Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A. 103(26):9918-23

Kassiri, Z., Zhong, J., Guo, D (...) Penninger, JM., Oudit, GY. (2009). Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail. 2(5):446-55

Liu, Z., Huang, XR., Chen, HY., Penninger, JM., Lan, HY. (2012). Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy. Lab Invest. 92(5):650-61

Wong, DW., Oudit, GY., Reich, H (...) Herzenberg, AM., Scholey, JW. (2007). Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol. 171(2):438-51

Oudit, GY., Herzenberg, AM., Kassiri, Z (...) Penninger, JM., Scholey, JW. (2006). Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. Am J Pathol. 168(6):1808-20

Wang, W., McKinnie, SM., Patel, VB (...) Murray, AG., Oudit, GY. (2013). Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc. 2(4):e000249

Koletar, MM., Cheng, HY., Penninger, JM., Ralph, MR. (2011). Loss of dexras1 alters nonphotic circadian phase shifts and reveals a role for the intergeniculate leaflet (IGL) in gene-targeted mice. Chronobiol Int. 28(7):553-62

Stephen, J., Nampoothiri, S., Banerjee, A (...) Gahl, WA., Malicdan, MCV. (2018). Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy. Hum Genet. 137(4):293-303

Guo, D., Kassiri, Z., Basu, R (...) Backx, PH., Oudit, GY. (2010). Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circ Res. 107(10):1275-89

Oudit, GY., Kassiri, Z., Zhou, J (...) Scholey, JW., Penninger, JM. (2008). Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovasc Res. 78(3):505-14

Devignot, S., Sha, TW., Burkard, TR (...) Penninger, JM., Weber, F. (2023). Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses. Life Sci Alliance. 6(7)

Bachmaier, K., Pummerer, C., Kozieradzki, I (...) Neu, N., Penninger, JM. (1997). Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease. Circulation. 95(3):655-61

Tsukasaki, M., Hamada, K., Okamoto, K (...) Penninger, JM., Takayanagi, H. (2017). LOX Fails to Substitute for RANKL in Osteoclastogenesis. J Bone Miner Res. 32(3):434-439

Waterhouse, P., Penninger, JM., Timms, E (...) Griesser, H., Mak, TW. (1995). Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. 270(5238):985-8

Mouri, Y., Yano, M., Shinzawa, M (...) Akiyama, T., Matsumoto, M. (2011). Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. J Immunol. 186(9):5047-57

Openshaw, RL., Thomson, DM., Thompson, R (...) Morris, BJ., Dawson, N. (2020). Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia. Schizophr Bull. 46(1):211-223

Andergassen, D., Dotter, CP., Wenzel, D (...) Pauler, FM., Hudson, QJ. (2017). Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. Elife. 6

Paul, DS., Albers, CA., Rendon, A (...) Ouwehand, WH., Deloukas, P. (2013). Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Res. 23(7):1130-41

Starkl, P., Jonsson, G., Artner, T (...) Penninger, JM., Cronin, SJF. (2023). Mast cell-derived BH4 is a critical mediator of postoperative pain. bioRxiv.

Einwallner, E., Kiefer, FW., Di Caro, G (...) Esterbauer, H., Todoric, J. (2016). Mast cells are not associated with systemic insulin resistance. Eur J Clin Invest. 46(11):911-919

Penninger, JM., Wallace, VA., Timms, E., Mak, TW. (1994). Maternal transfer of infectious mouse mammary tumor retroviruses does not depend on clonal deletion of superantigen-reactive V beta 14+ T cells. Eur J Immunol. 24(5):1102-8

Openshaw, RL., Thomson, DM., Penninger, JM., Pratt, JA., Morris, BJ. (2017). Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline. Psychopharmacology (Berl). 234(2):293-305

Timper, K., Paeger, L., Sánchez-Lasheras, C (...) Kloppenburg, P., Brüning, JC. (2018). Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Rep. 25(2):383-397.e10

Penninger, JM., Kroemer, G. (2003). Mitochondria, AIF and caspases--rivaling for cell death execution. Nat Cell Biol. 5(2):97-9

Daugas, E., Susin, SA., Zamzami, N (...) Penninger, J., Kroemer, G. (2000). Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J. 14(5):729-39

Wada, T., Penninger, JM. (2004). Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 23(16):2838-49

Kotsinas, A., Papanagnou, P., Galanos, P (...) Bartek, J., Gorgoulis, VG. (2014). MKK7 and ARF: new players in the DNA damage response scenery. Cell Cycle. 13(8):1227-36

Wada, T., Nishina, H., Katada, T., Penninger, JM. (2004). MKK7 couples stress signalling to G2/M cell cycle progression and cellular senescence. Exper. Med.. 22:1398-400

Wada, T., Joza, N., Cheng, HY (...) Nishina, H., Penninger, JM. (2004). MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol. 6(3):215-26

Shin, T., Hiraoka, Y., Yamasaki, T (...) Kofuji, S., Nishina, H. (2021). MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes Cells. 26(1):5-17

Morisaki, I., Shiraishi, H., Fujinami, H (...) Fujiki, M., Hanada, T. (2021). Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10. Biochem Biophys Res Commun. 570:60-66

Eriksson, U., Kopf, M., Afanasyeva, M., Penninger, JM. (2005). Models of autoimmune heart disease: a review of current status. Drug Discovery Today: Disease Models, online edition.

Penninger, JM., Kroemer, G. (1998). Molecular and cellular mechanisms of T lymphocyte apoptosis. Adv Immunol. 68:51-144

Susin, SA., Lorenzo, HK., Zamzami, N (...) Penninger, JM., Kroemer, G. (1999). Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 397(6718):441-6

Kong, YY., Penninger, JM. (2000). Molecular control of bone remodeling and osteoporosis. Exp Gerontol. 35(8):947-56

Krawczyk, C., Penninger, JM. (2001). Molecular controls of antigen receptor clustering and autoimmunity. Trends Cell Biol. 11(5):212-20

Galluzzi, L., Baehrecke, EH., Ballabio, A (...) Zhong, Q., Kroemer, G. (2017). Molecular definitions of autophagy and related processes. EMBO J. 36(13):1811-1836

Galluzzi, L., Vitale, I., Aaronson, SA (...) Melino, G., Kroemer, G. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 25(3):486-541

Krawczyk, C., Penninger, JM. (2001). Molecular motors involved in T cell receptor clusterings. J Leukoc Biol. 69(3):317-30

Penninger, J., Wallace, VA., Kishihara, K (...) Krause, H., Mak, TW. (1991). Molecular organization, ontogeny and expression of murine alpha beta and gamma delta T cell receptors. Exp Clin Immunogenet. 8(2):57-74

Wang, W., Yang, P., Zhong, Y (...) Wang, X., Jiang, C. (2013). Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury. Cell Res. 23(4):577-80

Taschler, U., Radner, FP., Heier, C (...) Zechner, R., Zimmermann, R. (2011). Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem. 286(20):17467-77

Kuba, K., Imai, Y., Penninger, JM. (2013). Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases. Circ J. 77(2):301-8

Dufresne, SS., Dumont, NA., Boulanger-Piette, A (...) Tupling, AR., Frenette, J. (2016). Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles. Am J Physiol Cell Physiol. 310(8):C663-72

Joza, N., Oudit, GY., Brown, D (...) Rustin, P., Penninger, JM. (2005). Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol. 25(23):10261-72

Kolas, NK., Marcon, E., Crackower, MA (...) Spyropoulos, B., Moens, PB. (2005). Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility. Chromosoma. 114(2):92-102

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Waterhouse, P., Bachmann, MF., Penninger, JM., Ohashi, PS., Mak, TW. (1997). Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice. Eur J Immunol. 27(8):1887-92

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Hassler, L., Penninger, J., Batlle, D. (2022). On the essentiality of the angiotensin converting enzyme 2 receptor for SARS-CoV-2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants causing COVID-19. Clin Transl Med. 12(10):e1080

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Kong, YY., Boyle, WJ., Penninger, JM. (1999). Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development. Immunol Cell Biol. 77(2):188-93

Kong, YY., Boyle, WJ., Penninger, JM. (2000). Osteoprotegerin ligand: a regulator of immune responses and bone physiology. Immunol Today. 21(10):495-502

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Haschke, M., Schuster, M., Poglitsch, M (...) Penninger, J., Krähenbühl, S. (2013). Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clin Pharmacokinet. 52(9):783-92

Cronin, SJF., Rao, S., Tejada, MA (...) Penninger, JM., Woolf, CJ. (2022). Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer. Sci Transl Med. 14(660):eabj1531

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Fischer, L., Gukovskaya, AS., Penninger, JM (...) Gukovsky, I., Pandol, SJ. (2007). Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca(2+) responses in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 292(3):G875-86

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Oudit, GY., Crackower, MA., Eriksson, U (...) Backx, PH., Penninger, JM. (2003). Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 108(17):2147-52

Jin, R., Yu, S., Song, Z (...) Granger, DN., Li, G. (2010). Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke. Biochem Biophys Res Commun. 399(3):458-64

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Shambharkar, PB., Blonska, M., Pappu, BP (...) Penninger, J., Lin, X. (2007). Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J. 26(7):1794-805

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Meng, X., Arocena, M., Penninger, J (...) Zhao, M., Song, B. (2011). PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Exp Neurol. 227(1):210-7

Haubner, B. J., Neely, G., Pachinger, O., Penninger, J. M., Metzler, B. (2008). PI3Kgamma AKTing during myocardial ischemia and reperfusion. Wiener Klin. Wochenschrift. (15):95-97

Haubner, BJ., Neely, GG., Voelkl, JG (...) Penninger, JM., Metzler, B. (2010). PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. PLoS One. 5(2):e9350

Hayer, S., Pundt, N., Peters, MA (...) Schett, G., Pap, T. (2009). PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis. FASEB J. 23(12):4288-98

Gruber, T., Hermann-Kleiter, N., Hinterleitner, R (...) Penninger, JM., Baier, G. (2009). PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Sci Signal. 2(76):ra30

Griffiths, EK., Krawczyk, C., Kong, YY (...) Rudd, CE., Penninger, JM. (2001). Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science. 293(5538):2260-3

Kokotović, T., Langeslag, M., Lenartowicz, EM (...) Penninger, JM., Nagy, V. (2021). PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life. Front Mol Neurosci. 14:720973

Ganglberger, F., Kaczanowska, J., Penninger, JM (...) Bühler, K., Haubensak, W. (2018). Predicting functional neuroanatomical maps from fusing brain networks with genetic information. Neuroimage. 170:113-120

Gonzalez-Espinosa, C., Odom, S., Olivera, A (...) Penninger, JM., Rivera, J. (2003). Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med. 197(11):1453-65

Zhong, J., Guo, D., Chen, CB (...) Kassiri, Z., Oudit, GY. (2011). Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension. 57(2):314-22

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Lee, HJ., Gallego-Ortega, D., Ledger, A (...) Penninger, JM., Ormandy, CJ. (2013). Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development. 140(7):1397-401

Marengère, LE., Mirtsos, C., Kozieradzki, I (...) Mak, TW., Penninger, JM. (1997). Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells. J Immunol. 159(1):70-6

Garreta, E., Moya-Rull, D., Stanifer, ML (...) Penninger, JM., Montserrat, N. (2022). Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells. STAR Protoc. 3(4):101872

Cronin, SJF., Tejada, MA., Song, R (...) Koyuncu, OO., Penninger, JM. (2023). Pseudorabies virus hijacks DDX3X, initiating an addictive "mad itch" and immune suppression, to facilitate viral spread. bioRxiv.

Cronin, SJF., Seehus, C., Weidinger, A (...) Woolf, CJ., Penninger, JM. (2019). Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 572(7769):E18

Fujiwara, S., Hoshizaki, M., Ichida, Y (...) Kuba, K., Imai, Y. (2019). Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. Nat Microbiol. 4(2):258-268

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Lee, NJ., Clarke, IM., Zengin, A (...) Baldock, PA., Herzog, H. (2019). RANK deletion in neuropeptide Y neurones attenuates oestrogen deficiency-related bone loss. J Neuroendocrinol. 31(2):e12687

Paolino, M., Koglgruber, R., Cronin, SJF (...) Kautzky-Willer, A., Penninger, JM. (2021). RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy. Nature. 589(7842):442-447

Rao, S., Sigl, V., Wimmer, RA (...) Dougall, W., Penninger, JM. (2017). RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer. Genes Dev. 31(20):2099-2112

Joshi, PA., Waterhouse, PD., Kannan, N (...) Eaves, C., Khokha, R. (2015). RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5(1):31-44

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Theill, LE., Boyle, WJ., Penninger, JM. (2002). RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol. 20:795-823

Leibbrandt, A., Penninger, J. M. (2008). RANK(L) as a key target for controlling bone loss. In: Therapeutic Targets of the TNF Superfamily. Ed. I. Grewal. Landes Bioscience/Eurekah.com.

Leibbrandt, A., Penninger, JM. (2009). RANK(L) as a key target for controlling bone loss. Adv Exp Med Biol. 647:130-45

Leibbrandt, A., Penninger, JM. (2008). RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci. 1143:123-50

Wunderle, M., Ruebner, M., Häberle, L (...) Schneider, MO., Fasching, PA. (2020). RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women. Sci Rep. 10(1):5171

Nakashima, T., Wada, T., Penninger, JM. (2003). RANKL and RANK as novel therapeutic targets for arthritis. Curr Opin Rheumatol. 15(3):280-7

Onji, M., Penninger, JM. (2023). RANKL and RANK in Cancer Therapy. Physiology (Bethesda). 38(3)

Schramek, D., Sigl, V., Penninger, JM. (2011). RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis. Trends Endocrinol Metab. 22(5):188-94

Rao, S., Cronin, SJF., Sigl, V., Penninger, JM. (2018). RANKL and RANK: From Mammalian Physiology to Cancer Treatment. Trends Cell Biol. 28(3):213-223

Chen, Y., Di Grappa, MA., Molyneux, SD (...) Penninger, JM., Khokha, R. (2015). RANKL blockade prevents and treats aggressive osteosarcomas. Sci Transl Med. 7(317):317ra197

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Sigl, V., Penninger, JM. (2014). RANKL/RANK - from bone physiology to breast cancer. Cytokine Growth Factor Rev. 25(2):205-14

Leibbrandt, A., Penninger, JM. (2009). RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies. Adv Exp Med Biol. 649:100-13

Sigl, V., Owusu-Boaitey, K., Joshi, PA (...) Jones, LP., Penninger, JM. (2016). RANKL/RANK control Brca1 mutation- . Cell Res. 26(7):761-74

Kondegowda, NG., Filipowska, J., Do, JS (...) Levy, CJ., Vasavada, RC. (2023). RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes. Sci Adv. 9(44):eadf5238

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Sigl, V., Jones, LP., Penninger, JM. (2016). RANKL/RANK: from bone loss to the prevention of breast cancer. Open Biol. 6(11)

Abdelilah-Seyfried, S., Iruela-Arispe, ML., Penninger, JM (...) Vikkula, M., Cleaver, O. (2022). Recalibrating vascular malformations and mechanotransduction by pharmacological intervention. J Clin Invest. 132(8)

Maruyama, K., Takada, Y., Ray, N (...) Yasuda, H., Matsuo, K. (2006). Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice. J Immunol. 177(6):3799-805

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Kim, NS., Kim, HJ., Koo, BK (...) Penninger, JM., Kong, YY. (2006). Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol. 26(3):1002-13

Habbeddine, M., Verthuy, C., Rastoin, O (...) Penninger, JM., Lawrence, T. (2017). Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone. Cell Rep. 21(9):2515-2527

Boyd, R., Kozieradzki, I., Chidgey, A (...) Mak, TW., Penninger, JM. (1998). Receptor-specific allelic exclusion of TCRV alpha-chains during development. J Immunol. 161(4):1718-27

Treml, B., Neu, N., Kleinsasser, A (...) Penninger, J., Loeckinger, A. (2010). Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. Crit Care Med. 38(2):596-601

Kleinsasser, A., Pircher, I., Treml, B (...) Penninger, JM., Loeckinger, A. (2012). Recombinant angiotensin-converting enzyme 2 suppresses pulmonary vasoconstriction in acute hypoxia. Wilderness Environ Med. 23(1):24-30

Oudit, GY., Penninger, JM. (2011). Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy. Curr Heart Fail Rep. 8(3):176-83

John, L., Vernersson, C., Kwon, H (...) Penninger, JM., Mirazimi, A. (2022). Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study. Pathogens. 11(5)

Szoták-Ajtay, K., Szõke, D., Kovács, G (...) Kahn, ML., Jakus, Z. (2020). Reduced Prenatal Pulmonary Lymphatic Function Is Observed in <i>Clp1</i> ^<i>K/K</i> Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth. Front Bioeng Biotechnol. 8:136

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Khan, Q., Penninger, JM., Yang, L (...) Kozieradzki, I., Zhang, L. (1999). Regulation of apoptosis in mature alphabeta+CD4-CD8- antigen-specific suppressor T cell clones. J Immunol. 162(10):5860-7

Jones, DH., Nakashima, T., Sanchez, OH (...) Wada, T., Penninger, JM. (2006). Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 440(7084):692-6

Crackower, MA., Oudit, GY., Kozieradzki, I (...) Backx, PH., Penninger, JM. (2002). Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 110(6):737-49

Loeser, S., Penninger, JM. (2007). Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b. Semin Immunol. 19(3):206-14

Oliveira-Dos-Santos, AJ., Matsumoto, G., Snow, BE (...) Siderovski, DP., Penninger, JM. (2000). Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci U S A. 97(22):12272-7

Loeser, S., Penninger, J.M. (2009). Regulation of T cell anergy and escape from regulatory T cells suppression by Cbl-b. In: The Epigenetics of Autoimmune disease. Ed. N. Zouali. :pp. 75-94

Lutz-Nicoladoni, C., Wallner, S., Stoitzner, P (...) Baier, G., Wolf, D. (2012). Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine. Immunol Cell Biol. 90(1):130-4

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Ito, N., Yokomizo, T., Sasaki, T (...) Hanaoka, K., Shimizu, T. (2002). Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. J Biol Chem. 277(47):44898-904

Penninger, JM., Bachmaier, K. (2000). Review of microbial infections and the immune response to cardiac antigens. J Infect Dis. 181 Suppl 3:S498-504

Martin-McCaffrey, L., Willard, FS., Oliveira-dos-Santos, AJ (...) Siderovski, DP., D'Souza, SJ. (2004). RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell. 7(5):763-9

Jones, DH., Kong, YY., Penninger, JM. (2002). Role of RANKL and RANK in bone loss and arthritis. Ann Rheum Dis. 61 Suppl 2:ii32-9

Wang, X., Huang, G., Luo, X., Penninger, JM., Muallem, S. (2004). Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells. J Biol Chem. 279(40):41642-9

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van der Harst, P., Zhang, W., Mateo Leach, I (...) Soranzo, N., Chambers, JC. (2012). Seventy-five genetic loci influencing the human red blood cell. Nature. 492(7429):369-75

Hasan Ali, O., Bomze, D., Risch, L (...) Penninger, JM., Flatz, L. (2021). Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies. Clin Infect Dis. 73(9):e2869-e2874

Suzuki, N., Suzuki, S., Duncan, GS (...) Mak, TW., Yeh, WC. (2002). Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 416(6882):750-6

Giuriato, S., Pesesse, X., Bodin, S (...) Erneux, C., Payrastre, B. (2003). SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels. Biochem J. 376(Pt 1):199-207

Liu, Q., Sasaki, T., Kozieradzki, I (...) Dumont, DJ., Penninger, JM. (1999). SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev. 13(7):786-91

Charlier, E., Condé, C., Zhang, J (...) Piette, J., Gloire, G. (2010). SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity. Leukemia. 24(4):821-32

Tejada, MA., Montilla-García, A., Cronin, SJ (...) Baeyens, JM., Cobos, EJ. (2017). Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice. Proc Natl Acad Sci U S A. 114(31):8396-8401

Bravo-Caparrós, I., Ruiz-Cantero, MC., Perazzoli, G (...) Cobos, EJ., Nieto, FR. (2020). Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury. FASEB J. 34(4):5951-5966

Penninger, JM., Mak, TW. (1994). Signal transduction, mitotic catastrophes, and death in T-cell development. Immunol Rev. 142:231-72

Talbot, S., Abdulnour, RE., Burkett, PR (...) Levy, BD., Woolf, CJ. (2015). Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 87(2):341-54

Fennell, LM., Gomez Diaz, C., Deszcz, L (...) Penninger, J., Ikeda, F. (2020). Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling. EMBO J. 39(24):e103303

Saade, M., Irla, M., Yammine, M (...) Chauvet, S., Nguyen, C. (2010). Spatial (Tbata) expression in mature medullary thymic epithelial cells. Eur J Immunol. 40(2):530-8

Wang, X., Zeng, W., Soyombo, AA (...) Greengard, P., Muallem, S. (2005). Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol. 7(4):405-11

Nakamichi, Y., Mizoguchi, T., Arai, A (...) Udagawa, N., Takahashi, N. (2012). Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice. Proc Natl Acad Sci U S A. 109(25):10006-11

Penninger, JM., Wen, T., Timms, E (...) Kronenberg, M., Mak, TW. (1995). Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice. Nature. 375(6528):241-4

Loeser, S., Loser, K., Bijker, MS (...) Melief, CJ., Penninger, JM. (2007). Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med. 204(4):879-91

Penninger, JM., Woodgett, J. (2001). Stem cells. PTEN--coupling tumor suppression to stem cells? Science. 294(5549):2116-8

Tsukasaki, M., Huynh, NC., Okamoto, K (...) Penninger, JM., Takayanagi, H. (2020). Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution. Nat Metab. 2(12):1382-1390

Furuya, Y., Inagaki, A., Khan, M (...) Uchida, K., Yasuda, H. (2013). Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity. J Biol Chem. 288(8):5562-71

Nishitai, G., Shimizu, N., Negishi, T (...) Nishina, H., Katada, T. (2004). Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells. J Biol Chem. 279(3):1621-6

Wada, T., Penninger, JM. (2004). Stress kinase MKK7: savior of cell cycle arrest and cellular senescence. Cell Cycle. 3(5):577-9

Yamasaki, T., Kawasaki, H., Arakawa, S (...) Katada, T., Nishina, H. (2011). Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J Neurosci. 31(46):16872-83

Nishina, H., Fischer, KD., Radvanyi, L (...) Woodgett, JR., Penninger, JM. (1997). Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature. 385(6614):350-3

Capraz, T., Kienzl, NF., Laurent, E (...) Oostenbrink, C., Stadlmann, J. (2021). Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor. Elife. 10

Wang, QP., Lin, YQ., Zhang, L (...) Herzog, H., Neely, GG. (2016). Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response. Cell Metab. 24(1):75-90

Opavsky, MA., Penninger, J., Aitken, K (...) Mak, T., Liu, P. (1999). Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection. Circ Res. 85(6):551-8

Kozieradzki, I., Kündig, T., Kishihara, K (...) Mak, TW., Penninger, JM. (1997). T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45. J Immunol. 158(7):3130-9

Suzuki, A., Yamaguchi, MT., Ohteki, T (...) Nakano, T., Mak, TW. (2001). T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 14(5):523-34

Wallace, VA., Kawai, K., Levelt, CN (...) Ohashi, PS., Eichmann, K. (1995). T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes. Eur J Immunol. 25(5):1312-8

Rangachari, M., Mauermann, N., Marty, RR (...) Penninger, JM., Eriksson, U. (2006). T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med. 203(8):2009-19

Yeung, RS., Penninger, J., Mak, TW. (1994). T-cell development and function in gene-knockout mice. Curr Opin Immunol. 6(2):298-307

Qiao, G., Li, Z., Molinero, L (...) Penninger, JM., Zhang, J. (2008). T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol. 28(7):2470-80

Pospisilik, JA., Knauf, C., Joza, N (...) Burcelin, R., Penninger, JM. (2007). Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell. 131(3):476-91

Song, K., Yang, X., An, G (...) Liu, Z., Zhao, XY. (2022). Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models. Nat Commun. 13(1):7335

Mastrella, G., Hou, M., Li, M (...) Glass, R., Kälin, RE. (2019). Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma. Cancer Res. 79(9):2298-2313

Ajoolabady, A., Wang, S., Kroemer, G (...) Klionsky, DJ., Ren, J. (2021). Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics. Pharmacol Ther. 225:107848

Raglow, Z., McKenna, MK., Bonifant, CL (...) Brenner, MK., Markovitz, DM. (2022). Targeting Glycans for CAR Therapy: the Advent of Sweet CARs. Mol Ther.

Wysocki, J., Ye, M., Rodriguez, E (...) Penninger, JM., Batlle, D. (2010). Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 55(1):90-8

Wolle, P., Hardick, J., Cronin, SJF (...) Penninger, JM., Rauh, D. (2019). Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors. J Med Chem. 62(5):2843-2848

Ming, J., Cronin, SJF., Penninger, JM. (2020). Targeting the RANKL/RANK/OPG Axis for Cancer Therapy. Front Oncol. 10:1283

Gronski, MA., Boulter, JM., Moskophidis, D (...) Gascoigne, NR., Ohashi, PS. (2004). TCR affinity and negative regulation limit autoimmunity. Nat Med. 10(11):1234-9

Zhong, JC., Ye, JY., Jin, HY (...) Penninger, JM., Oudit, GY. (2011). Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression. Regul Pept. 166(1-3):90-7

Sohal, DS., Nghiem, M., Crackower, MA (...) Penninger, JM., Molkentin, JD. (2001). Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res. 89(1):20-5

Penninger, JM., Crabtree, GR. (1999). The actin cytoskeleton and lymphocyte activation. Cell. 96(1):9-12

Hara, H., Ishihara, C., Takeuchi, A (...) Penninger, JM., Saito, T. (2007). The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol. 8(6):619-29

Andergassen, D., Muckenhuber, M., Bammer, PC (...) Pauler, FM., Hudson, QJ. (2019). The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes. PLoS Genet. 15(7):e1008268

Xu, H., Su, Z., Wu, J (...) Kvietys, PR., Rui, T. (2010). The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. J Immunol. 184(3):1492-8

Atfield, AD., Liu, P., Penninger JM. (2006). The biochemical mechanisms of T-cell anergy Curr. Immunol. Rev.. 2:73-99

Roumier, T., Vieira, HL., Castedo, M (...) Roques, B., Kroemer, G. (2002). The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway. Cell Death Differ. 9(11):1212-9

Yamaguchi, T., Suzuki, T., Sato, T (...) Imai, Y., Kuba, K. (2018). The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 11(516)

Maté, MJ., Ortiz-Lombardía, M., Boitel, B (...) Kroemer, G., Alzari, PM. (2002). The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol. 9(6):442-6

Hakem, A., Sasaki, T., Kozieradzki, I., Penninger, JM. (1999). The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J Exp Med. 189(6):957-68

Hikosaka, Y., Nitta, T., Ohigashi, I (...) Akiyama, T., Takahama, Y. (2008). The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity. 29(3):438-50

Penninger, J., Imai, Y., Kuba, K. (2008). The discovery of ACE2 and its role in acute lung injury. Exp Physiol.

Imai, Y., Kuba, K., Penninger, JM. (2008). The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Exp Physiol. 93(5):543-8

Paolino, M., Choidas, A., Wallner, S (...) Klebl, BM., Penninger, JM. (2014). The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 507(7493):508-12

Zhang, L., Anglesio, MS., O'Sullivan, M (...) Sorensen, PH., Penninger, JM. (2007). The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 13(9):1060-9

Papanikos, F., Daniel, K., Goercharn-Ramlal, A (...) Stewart, AF., Toth, A. (2017). The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice. Chromosoma. 126(3):399-415

Nagy, V., Cole, T., Van Campenhout, C (...) Neely, GG., Penninger, JM. (2015). The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle. 14(12):1799-808

Bachmann, MF., Nitschke, L., Krawczyk, C (...) Fischer, KD., Penninger, JM. (1999). The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens. J Immunol. 163(1):137-42

Turgu, B., El-Naggar, A., Kogler, M (...) Penninger, JM., Sorensen, PH. (2023). The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes. EMBO Rep. :e56815

Kim, C., Marchal, CC., Penninger, J., Dinauer, MC. (2003). The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions. J Immunol. 171(8):4425-30

Cheloufi, S., Elling, U., Hopfgartner, B (...) Zuber, J., Hochedlinger, K. (2015). The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 528(7581):218-24

Hagelkruys, A., Horrer, M., Taubenschmid-Stowers, J (...) Knoblich, JA., Penninger, JM. (2022). The HUSH complex controls brain architecture and protocadherin fidelity. Sci Adv. 8(44):eabo7247

Mischkulnig, M., Kiesel, B., Rötzer-Pejrimovsky, T (...) Widhalm, G., Erhart, F. (2022). The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers. Front Mol Neurosci. 15:928355

Penninger, JM., Neu, N., Timms, E (...) Pummerer, C., Mak, TW. (1993). The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]. J Exp Med. 178(5):1837-42

Liu, Q., Oliveira-Dos-Santos, AJ., Mariathasan, S (...) Penninger, JM., Dumont, DJ. (1998). The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med. 188(7):1333-42

Penninger, JM., Sirard, C., Mittrücker, HW (...) Matsuyama, T., Mak, TW. (1997). The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. Immunity. 7(2):243-54

Morita, M., Kuba, K., Ichikawa, A (...) Arita, M., Imai, Y. (2013). The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell. 153(1):112-25

Hara, H., Wada, T., Bakal, C (...) Rottapel, R., Penninger, JM. (2003). The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 18(6):763-75

Cronin, SJF., Seehus, C., Weidinger, A (...) Woolf, CJ., Penninger, JM. (2018). The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 563(7732):564-568

Okamoto-Uchida, Y., Yu, R., Miyamura, N (...) Azuma, N., Nishina, H. (2016). The mevalonate pathway regulates primitive streak formation via protein farnesylation. Sci Rep. 6:37697

Hara, H., Bakal, C., Wada, T (...) Saito, T., Penninger, JM. (2004). The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med. 200(9):1167-77

Joza, N., Galindo, K., Pospisilik, JA (...) Kroemer, G., Penninger, JM. (2008). The molecular archaeology of a mitochondrial death effector: AIF in Drosophila. Cell Death Differ. 15(6):1009-18

Cheng, HY., Dziema, H., Papp, J (...) Penninger, JM., Obrietan, K. (2006). The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci. 26(50):12984-95

Wada, T., Nakashima, T., Oliveira-dos-Santos, AJ (...) Schett, G., Penninger, JM. (2005). The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med. 11(4):394-9

Ang, CE., Ma, Q., Wapinski, OL (...) Wernig, M., Chang, HY. (2019). The novel lncRNA <i>lnc-NR2F1</i> is pro-neurogenic and mutated in human neurodevelopmental disorders. Elife. 8

Penninger, JM., Fischer, KD., Sasaki, T (...) Ohashi, PS., Bachmann, MF. (1999). The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation. Eur J Immunol. 29(5):1709-18

Fata, JE., Kong, YY., Li, J (...) Khokha, R., Penninger, JM. (2000). The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 103(1):41-50

Asanović, I., Strandback, E., Kroupova, A (...) Weitzer, S., Martinez, J. (2021). The oxidoreductase PYROXD1 uses NAD(P)⁺ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response. Mol Cell. 81(12):2520-2532.e16

Fielding, RA., Gunstad, J., Gustafson, DR (...) Phillips, DI., Scarmeas, N. (2013). The paradox of overnutrition in aging and cognition. Ann N Y Acad Sci. 1287:31-43

Kuwana, H., Terada, Y., Kobayashi, T (...) Sasaki, T., Sasaki, S. (2008). The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int. 73(4):430-45

Sasaki, T., Sasaki-Irie, J., Penninger, JM. (2002). The potential role of CD45 as a drug target. Curr. Topics Med. Chem.. 131:495-501

Nagy, V., Penninger, JM. (2015). The RANKL-RANK Story. Gerontology. 61(6):534-42

Imai, Y., Kuba, K., Penninger, JM., (2006). The renin angiotensin system in acute respiratory distress syndrome. Drug Discovery Today. 3:225-229

Szappanos, D., Tschismarov, R., Perlot, T (...) Penninger, JM., Decker, T. (2018). The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity. PLoS Pathog. 14(11):e1007397

Oudit, GY., Crackower, MA., Backx, PH., Penninger, JM. (2003). The role of ACE2 in cardiovascular physiology. Trends Cardiovasc Med. 13(3):93-101

Oudit, GY., Imai, Y., Kuba, K., Scholey, JW., Penninger, JM. (2009). The role of ACE2 in pulmonary diseases--relevance for the nephrologist. Nephrol Dial Transplant. 24(5):1362-5

Penninger, JM., Grant, MB., Sung, JJY. (2021). The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection. Gastroenterology. 160(1):39-46

Puri, KD., Doggett, TA., Huang, CY (...) Penninger, J., Diacovo, TG. (2005). The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood. 106(1):150-7

Cronin, SJF., Woolf, CJ., Weiss, G., Penninger, JM. (2019). The Role of Iron Regulation in Immunometabolism and Immune-Related Disease. Front Mol Biosci. 6:116

Tani-Ishii, N., Penninger, JM., Matsumoto, G., Teranaka, T., Umemoto, T. (2002). The role of LFA-1 in osteoclast development induced by co-cultures of mouse bone marrow cells and MC3T3-G2/PA6 cells. J Periodontal Res. 37(3):184-91

Penninger, JM., Wallace, VA., Kishihara, K., Mak, TW. (1993). The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection. Immunol Rev. 135:183-214

Oudit, GY., Sun, H., Kerfant, BG (...) Penninger, JM., Backx, PH. (2004). The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol. 37(2):449-71

Leibbrandt, A., Penninger, J. M. (2008). The role of RANKL in cancer. In: Encyclopedia of Cancer. Ed. Schwab, M. Springer.

Paolino, M., Penninger, JM. (2016). The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy. Cancers (Basel). 8(10)

Wallner, S., Lutz-Nicoladoni, C., Tripp, CH (...) Stoitzner, P., Wolf, D. (2013). The role of the e3 ligase cbl-B in murine dendritic cells. PLoS One. 8(6):e65178

Loeser, S., Penninger, J.M. (2008). The Role of the E3 ubiquitin ligase Cbl-b in T-cells signalling and tolerance. In: CBL Proteins. Ed. A. Tsygankov. Nova Science Publishers Inc. :Chapter 9

Liu, P., Penninger, J., Aitken, K., Sole, M., Mak, T. (1995). The role of transgenic knockout models in defining the pathogenesis of viral heart disease. Eur Heart J. 16 Suppl O:25-7

Sasaki, T., Wada, T., Kishimoto, H (...) Nishina, H., Penninger, JM. (2001). The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J Exp Med. 194(6):757-68

Schramek, D., Kotsinas, A., Meixner, A (...) Gorgoulis, VG., Penninger, JM. (2011). The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet. 43(3):212-9

Yoshida, H., Nishina, H., Takimoto, H (...) Crabtree, GR., Mak, TW. (1998). The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 8(1):115-24

Akiyama, T., Shimo, Y., Yanai, H (...) Takahama, Y., Inoue, J. (2008). The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 29(3):423-37

Tortola, L., Nitsch, R., Bertrand, MJM (...) Sorensen, PH., Penninger, JM. (2016). The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 15(7):1481-1492

Tortola, L., Nitsch, R., Bertrand, MJM (...) Sorensen, PH., Penninger, JM. (2016). The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 16(12):3414

Liu, P., Aitken, K., Kong, YY (...) Mak, TW., Penninger, JM. (2000). The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nat Med. 6(4):429-34

Loeser, S., Penninger, JM. (2007). The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity. Cell Cycle. 6(20):2478-85

Gomez-Diaz, C., Jonsson, G., Schodl, K (...) Penninger, JM., Ikeda, F. (2021). The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains. iScience. 24(11):103241

Oliveira-dos-Santos, AJ., Penninger, JM., Rieker-Geley, T (...) Mak, TM., Wick, G. (1998). Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression. Eur J Immunol. 28(9):2882-92

Penninger, J., Wick, G. (1992). Thymic nurse cell lymphocytes react against self major histocompatibility complex. Eur J Immunol. 22(1):79-83

Wick, G., Rieker, T., Penninger, J. (1991). Thymic nurse cells: a site for positive selection and differentiation of T cells. Curr Top Microbiol Immunol. 173:99-105

Penninger, JM., Mak, TW. (1998). Thymocyte selection in Vav and IRF-1 gene-deficient mice. Immunol Rev. 165:149-66

Irwin, MW., Mak, S., Mann, DL (...) Shou, Z., Liu, P. (1999). Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium. Circulation. 99(11):1492-8

Camargo, SM., Singer, D., Makrides, V (...) Penninger, JM., Verrey, F. (2009). Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations. Gastroenterology. 136(3):872-82

Leibbrandt, A., Penninger, JM. (2011). TNF conference 2009: beyond bones - RANKL/RANK in the immune system. Adv Exp Med Biol. 691:5-22

Tortola, L., Nitsch, R., Penninger, JM. (2016). TNF-driven cell fate: till HACE do us part. Oncotarget. 7(29):44871-44872

Ferrick, DA., Gemmell-Hori, L., Sydora, B (...) Kronenberg, M., Mak, TW. (1994). Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice. Int Rev Immunol. 11(4):295-304

Lomaga, MA., Yeh, WC., Sarosi, I (...) Goeddel, DV., Mak, TW. (1999). TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13(8):1015-24

Kokotović, T., Lenartowicz, EM., Langeslag, M (...) Penninger, JM., Nagy, V. (2022). Transcription factor Mesenchyme Homeobox Protein 2 (MEOX2) modulates nociceptor function. FEBS J.

Cheng, H.-YM., Penninger, JM. (2002). Transcriptional mechanisms underlying neuropathic pain: DREAM, transcription factors and future pain management? Exp. Rev. Neurotherapeutics. 2:677-89

Kuba, K., Imai, Y., Ohto-Nakanishi, T., Penninger, JM. (2010). Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther. 128(1):119-28

Dalgaard, K., Landgraf, K., Heyne, S (...) Körner, A., Pospisilik, JA. (2016). Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell. 164(3):353-64

Neely, GG., Keene, AC., Duchek, P (...) Garrity, PA., Penninger, JM. (2011). TrpA1 regulates thermal nociception in Drosophila. PLoS One. 6(8):e24343

Humbert, PO., Pryjda, TZ., Pranjic, B (...) Richardson, HE., Penninger, JM. (2022). TSPAN6 is a suppressor of Ras-driven cancer. Oncogene.

Awad, AE., Kandalam, V., Chakrabarti, S (...) Oudit, GY., Kassiri, Z. (2010). Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. Am J Physiol Cell Physiol. 298(3):C679-92

Susin, SA., Daugas, E., Ravagnan, L (...) Earnshaw, WC., Kroemer, G. (2000). Two distinct pathways leading to nuclear apoptosis. J Exp Med. 192(4):571-80

Inoue, M., Hada, K., Shiraishi, H (...) Ihara, K., Hanada, T. (2020). Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2. Biochem Biophys Res Commun. 525(3):726-732

Penninger, J., Rieker, T., Romani, N (...) Stössel, H., Wick, G. (1994). Ultrastructural analysis of thymic nurse cell epithelium. Eur J Immunol. 24(1):222-8

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