List of Publications

YearTitleJournalAuthors
2022On the essentiality of the angiotensin converting enzyme 2 receptor for SARS-CoV-2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants causing COVID-19.Clin Transl MedHassler, L., Penninger, J., Batlle, D.
2022Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide.Sci RepCikes, D., Atanes, P., Cronin, SJF., Hagelkrüys, A., Huang, GC., Persaud, SJ., Penninger, JM.
2022Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity.CellBatlle, D., Monteil, V., Garreta, E., Hassler, L., Wysocki, J., Chandar, V., Schwartz, RE., Mirazimi, A., Montserrat, N., Bader, M., Penninger, JM.
2022Recalibrating vascular malformations and mechanotransduction by pharmacological intervention.J Clin InvestAbdelilah-Seyfried, S., Iruela-Arispe, ML., Penninger, JM., Tournier-Lasserve, E., Vikkula, M., Cleaver, O.
2022Transcription factor Mesenchyme Homeobox Protein 2 (MEOX2) modulates nociceptor function.FEBS JKokotović, T., Lenartowicz, EM., Langeslag, M., Ciotu, CI., Fell, CW., Scaramuzza, A., Fischer, MJM., Kress, M., Penninger, JM., Nagy, V.
2022ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology.ElifeGawish, R., Starkl, P., Pimenov, L., Hladik, A., Lakovits, K., Oberndorfer, F., Cronin, SJ., Ohradanova-Repic, A., Wirnsberger, G., Agerer, B., Endler, L., Capraz, T., Perthold, JW., Cikes, D., Koglgruber, R., Hagelkruys, A., Montserrat, N., Mirazimi, A., Boon, L., Stockinger, H., Bergthaler, A., Oostenbrink, C., Penninger, JM., Knapp, S.
2022TSPAN6 is a suppressor of Ras-driven cancer.OncogeneHumbert, PO., Pryjda, TZ., Pranjic, B., Farrell, A., Fujikura, K., de Matos Simoes, R., Karim, R., Kozieradzki, I., Cronin, SJF., Neely, GG., Meyer, TF., Hagelkruys, A., Richardson, HE., Penninger, JM.
2022A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells.Cell MetabGarreta, E., Prado, P., Stanifer, ML., Monteil, V., Marco, A., Ullate-Agote, A., Moya-Rull, D., Vilas-Zornoza, A., Tarantino, C., Romero, JP., Jonsson, G., Oria, R., Leopoldi, A., Hagelkruys, A., Gallo, M., González, F., Domingo-Pedrol, P., Gavaldà, A., Del Pozo, CH., Hasan Ali, O., Ventura-Aguiar, P., Campistol, JM., Prosper, F., Mirazimi, A., Boulant, S., Penninger, JM., Montserrat, N.
2022Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells.Cell Mol Life SciRath, M., Schwefel, K., Malinverno, M., Skowronek, D., Leopoldi, A., Pilz, RA., Biedenweg, D., Bekeschus, S., Penninger, JM., Dejana, E., Felbor, U.
2022Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study.PathogensJohn, L., Vernersson, C., Kwon, H., Elling, U., Penninger, JM., Mirazimi, A.
2022Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants.EMBO Mol MedMonteil, V., Eaton, B., Postnikova, E., Murphy, M., Braunsfeld, B., Crozier, I., Kricek, F., Niederhöfer, J., Schwarzböck, A., Breid, H., Devignot, S., Klingström, J., Thålin, C., Kellner, MJ., Christ, W., Havervall, S., Mereiter, S., Knapp, S., Sanchez Jimenez, A., Bugajska-Schretter, A., Dohnal, A., Ruf, C., Gugenberger, R., Hagelkruys, A., Montserrat, N., Kozieradzki, I., Hasan Ali, O., Stadlmann, J., Holbrook, MR., Schmaljohn, C., Oostenbrink, C., Shoemaker, RH., Mirazimi, A., Wirnsberger, G., Penninger, JM.
2022Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer.PLoS OneShoemaker, RH., Panettieri, RA., Libutti, SK., Hochster, HS., Watts, NR., Wingfield, PT., Starkl, P., Pimenov, L., Gawish, R., Hladik, A., Knapp, S., Boring, D., White, JM., Lawrence, Q., Boone, J., Marshall, JD., Matthews, RL., Cholewa, BD., Richig, JW., Chen, BT., McCormick, DL., Gugensberger, R., Höller, S., Penninger, JM., Wirnsberger, G.
2022Targeting Glycans for CAR Therapy: the Advent of Sweet CARs.Mol TherRaglow, Z., McKenna, MK., Bonifant, CL., Wang, W., Pasca di Magliano, M., Stadlmann, J., Penninger, JM., Cummings, RD., Brenner, MK., Markovitz, DM.
2022ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury.PLoS OneMinato, T., Yamaguchi, T., Hoshizaki, M., Nirasawa, S., An, J., Takahashi, S., Penninger, JM., Imai, Y., Kuba, K.
2022AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia-Ischemia Injury.Mol NeurobiolLi, T., Sun, Y., Zhang, S., Xu, Y., Li, K., Xie, C., Wang, Y., Wang, Y., Cao, J., Wang, X., Penninger, JM., Kroemer, G., Blomgren, K., Zhu, C.
2022Pulmonary Surfactant Proteins are Inhibited by IgA Autoantibodies in Severe COVID-19.Am J Respir Crit Care MedSinnberg, T., Lichtensteiger, C., Hasan Ali, O., Pop, OT., Jochum, AK., Risch, L., Brugger, SD., Velic, A., Bomze, D., Kohler, P., Vernazza, P., Albrich, WC., Kahlert, CR., Abdou, MT., Wyss, N., Hofmeister, K., Niessner, H., Zinner, C., Gilardi, M., Tzankov, A., Röcken, M., Dulovic, A., Mairpady Shambat, S., Ruetalo, N., Buehler, PK., Scheier, TC., Jochum, W., Kern, L., Henz, S., Schneider, T., Kuster, GM., Lampart, M., Siegemund, M., Bingisser, R., Schindler, M., Schneiderhan-Marra, N., Kalbacher, H., McCoy, KD., Spengler, W., Brutsche, MH., Macek, B., Twerenbold, R., Penninger, JM., Matter, MS., Flatz, L.
2022Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer.Sci Transl MedCronin, SJF., Rao, S., Tejada, MA., Turnes, BL., Licht-Mayer, S., Omura, T., Brenneis, C., Jacobs, E., Barrett, L., Latremoliere, A., Andrews, N., Channon, KM., Latini, A., Arvanites, AC., Davidow, LS., Costigan, M., Rubin, LL., Penninger, JM., Woolf, CJ.
2022A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.Cell Rep MedChan, JF., Oh, YJ., Yuan, S., Chu, H., Yeung, ML., Canena, D., Chan, CC., Poon, VK., Chan, CC., Zhang, AJ., Cai, JP., Ye, ZW., Wen, L., Yuen, TT., Chik, KK., Shuai, H., Wang, Y., Hou, Y., Luo, C., Chan, WM., Qin, Z., Sit, KY., Au, WK., Legendre, M., Zhu, R., Hain, L., Seferovic, H., Tampé, R., To, KK., Chan, KH., Thomas, DG., Klausberger, M., Xu, C., Moon, JJ., Stadlmann, J., Penninger, JM., Oostenbrink, C., Hinterdorfer, P., Yuen, KY., Markovitz, DM.
2022The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers.Front Mol NeurosciMischkulnig, M., Kiesel, B., Rötzer-Pejrimovsky, T., Borkovec, M., Lang, A., Millesi, M., Wadiura, LI., Hervey-Jumper, S., Penninger, JM., Berger, MS., Widhalm, G., Erhart, F.
2022The HUSH complex controls brain architecture and protocadherin fidelity.Sci AdvHagelkruys, A., Horrer, M., Taubenschmid-Stowers, J., Kavirayani, A., Novatchkova, M., Orthofer, M., Pai, TP., Cikes, D., Zhuk, S., Balmaña, M., Esk, C., Koglgruber, R., Moeseneder, P., Lazovic, J., Zopf, LM., Cronin, SJF., Elling, U., Knoblich, JA., Penninger, JM.