List of Publications

Cikes, D., Leutner, M., Cronin, SJF (...) Orthofer, M., Penninger, JM. (2024). Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism. Nat Aging. 4(1):80-94

Quintard, C., Tubbs, E., Jonsson, G (...) Penninger, JM., Gidrol, X. (2024). A microfluidic platform integrating functional vascularized organoids-on-chip. Nat Commun. 15(1):1452

Frenz-Wiessner, S., Fairley, SD., Buser, M (...) Marr, C., Klein, C. (2024). Generation of complex bone marrow organoids from human induced pluripotent stem cells. Nat Methods.

Monteil, VM., Wright, SC., Dyczynski, M (...) Penninger, JM., Mirazimi, A. (2024). Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells. Nat Microbiol.

Lengacher, NA., Tomlinson, JJ., Jochum, AK (...) Woulfe, JM., Schlossmacher, MG. (2024). Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19. Acta Neuropathol Commun. 12(1):70

Stadlmann, J., Helm, J., Mereiter, S (...) Penninger, J., Altmann, F. (2024). Non-targeted isomer-sensitive N-glycome analysis reveals new layers of organ-specific diversity in mice. Res Sq.

Kilpiö, T., Skarp, S., Perjés, Á (...) Magga, J., Kerkelä, R. (2024). Apelin regulates skeletal muscle adaptation to exercise in a high-intensity interval training model. Am J Physiol Cell Physiol. 326(5):C1437-C1450

Onji, M., Penninger, JM. (2023). RANKL and RANK in Cancer Therapy. Physiology (Bethesda). 38(3)

Sinnberg, T., Lichtensteiger, C., Ali, OH (...) Matter, MS., Flatz, L. (2023). Pulmonary Surfactant Proteins Are Inhibited by Immunoglobulin A Autoantibodies in Severe COVID-19. Am J Respir Crit Care Med. 207(1):38-49

Liu, Q., Telezhkin, V., Jiang, W (...) Penninger, J., Song, B. (2023). Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation. Cell Biosci. 13(1):4

Salewskij, K., Penninger, JM. (2023). Blood Vessel Organoids for Development and Disease. Circ Res. 132(4):498-510

Taubenschmid-Stowers, J., Orthofer, M., Laemmerer, A (...) Horn, M., Penninger, JM. (2023). A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors. EMBO Mol Med. 15(3):e16959

Werschler, N., Penninger, J. (2023). Generation of Human Blood Vessel Organoids from Pluripotent Stem Cells. J Vis Exp. (191)

Yamada, D., Kojima, Y., Hosoya, A (...) Okamoto, R., Nagaishi, T. (2023). Apelin expression is downregulated in T cells in a murine model of chronic colitis. Biochem Biophys Res Commun. 647:72-79

Cikes, D., Elsayad, K., Sezgin, E (...) Banka, S., Penninger, JM. (2023). PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. Nat Metab. 5(3):495-515

Devignot, S., Sha, TW., Burkard, TR (...) Penninger, JM., Weber, F. (2023). Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses. Life Sci Alliance. 6(7)

Vitale, I., Pietrocola, F., Guilbaud, E (...) Kroemer, G., Galluzzi, L. (2023). Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. :1-58

Cronin, SJF., Davidow, LS., Arvanites, AC (...) Penninger, JM., Woolf, CJ. (2023). Implementation of a Drug Screening Platform to Target<i>Gch1</i> Expression in Injured Mouse Dorsal Root Ganglion Neurons. Bio Protoc. 13(9):e4666

Cronin, SJF., Tejada, MA., Song, R (...) Koyuncu, OO., Penninger, JM. (2023). Pseudorabies virus hijacks DDX3X, initiating an addictive "mad itch" and immune suppression, to facilitate viral spread. bioRxiv.

Malik, B., Vokic, I., Mohr, T (...) Sibilia, M., Csiszar, A. (2023). FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice. EMBO Mol Med. 15(7):e16758

Starkl, P., Jonsson, G., Artner, T (...) Penninger, JM., Cronin, SJF. (2023). Mast cell-derived BH4 is a critical mediator of postoperative pain. bioRxiv.

Onodera, Y., Liang, J., Li, Y (...) Mubareka, S., Zhang, H. (2023). Inhalation of ACE2 as a therapeutic target on sex-bias differences in SARS-CoV-2 infection and variant of concern. iScience. 26(8):107470

Turgu, B., El-Naggar, A., Kogler, M (...) Penninger, JM., Sorensen, PH. (2023). The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes. EMBO Rep. :e56815

Wang, K., Khoramjoo, M., Srinivasan, K (...) Prasad, V., Oudit, GY. (2023). Sequential multi-omics analysis identifies clinical phenotypes and predictive biomarkers for long COVID. Cell Rep Med. :101254

Monteil, V., Kwon, H., John, L (...) Penninger, JM., Mirazimi, A. (2023). Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections. Nat Commun. 14(1):6785

Kondegowda, NG., Filipowska, J., Do, JS (...) Levy, CJ., Vasavada, RC. (2023). RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes. Sci Adv. 9(44):eadf5238

Oudit, GY., Wang, K., Viveiros, A., Kellner, MJ., Penninger, JM. (2023). Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic. Cell. 186(5):906-922

Cikes, D., Elsayad, K., Sezgin, E (...) Banka, S., Penninger, JM. (2023). Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. Nat Metab.

Garreta, E., Moya-Rull, D., Stanifer, ML (...) Penninger, JM., Montserrat, N. (2022). Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells. STAR Protoc. 3(4):101872

Hassler, L., Penninger, J., Batlle, D. (2022). On the essentiality of the angiotensin converting enzyme 2 receptor for SARS-CoV-2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants causing COVID-19. Clin Transl Med. 12(10):e1080

Cikes, D., Atanes, P., Cronin, SJF (...) Persaud, SJ., Penninger, JM. (2022). Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide. Sci Rep. 12(1):9383

Batlle, D., Monteil, V., Garreta, E (...) Bader, M., Penninger, JM. (2022). Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity. Cell. 185(11):1837-1839

Abdelilah-Seyfried, S., Iruela-Arispe, ML., Penninger, JM (...) Vikkula, M., Cleaver, O. (2022). Recalibrating vascular malformations and mechanotransduction by pharmacological intervention. J Clin Invest. 132(8)

Kokotović, T., Lenartowicz, EM., Langeslag, M (...) Penninger, JM., Nagy, V. (2022). Transcription factor Mesenchyme Homeobox Protein 2 (MEOX2) modulates nociceptor function. FEBS J.

Gawish, R., Starkl, P., Pimenov, L (...) Penninger, JM., Knapp, S. (2022). ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology. Elife. 11

Humbert, PO., Pryjda, TZ., Pranjic, B (...) Richardson, HE., Penninger, JM. (2022). TSPAN6 is a suppressor of Ras-driven cancer. Oncogene.

Garreta, E., Prado, P., Stanifer, ML (...) Penninger, JM., Montserrat, N. (2022). A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells. Cell Metab.

Rath, M., Schwefel, K., Malinverno, M (...) Dejana, E., Felbor, U. (2022). Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells. Cell Mol Life Sci. 79(6):340

John, L., Vernersson, C., Kwon, H (...) Penninger, JM., Mirazimi, A. (2022). Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study. Pathogens. 11(5)

Monteil, V., Eaton, B., Postnikova, E (...) Wirnsberger, G., Penninger, JM. (2022). Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants. EMBO Mol Med. :e15230

Shoemaker, RH., Panettieri, RA., Libutti, SK (...) Penninger, JM., Wirnsberger, G. (2022). Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer. PLoS One. 17(7):e0271066

Raglow, Z., McKenna, MK., Bonifant, CL (...) Brenner, MK., Markovitz, DM. (2022). Targeting Glycans for CAR Therapy: the Advent of Sweet CARs. Mol Ther.

Minato, T., Yamaguchi, T., Hoshizaki, M (...) Imai, Y., Kuba, K. (2022). ACE2-like enzyme B38-CAP suppresses abdominal sepsis and severe acute lung injury. PLoS One. 17(7):e0270920

Li, T., Sun, Y., Zhang, S (...) Blomgren, K., Zhu, C. (2022). AIF Overexpression Aggravates Oxidative Stress in Neonatal Male Mice After Hypoxia-Ischemia Injury. Mol Neurobiol.

Cronin, SJF., Rao, S., Tejada, MA (...) Penninger, JM., Woolf, CJ. (2022). Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer. Sci Transl Med. 14(660):eabj1531

Chan, JF., Oh, YJ., Yuan, S (...) Yuen, KY., Markovitz, DM. (2022). A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo. Cell Rep Med. :100774

Mischkulnig, M., Kiesel, B., Rötzer-Pejrimovsky, T (...) Widhalm, G., Erhart, F. (2022). The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers. Front Mol Neurosci. 15:928355

Hagelkruys, A., Horrer, M., Taubenschmid-Stowers, J (...) Knoblich, JA., Penninger, JM. (2022). The HUSH complex controls brain architecture and protocadherin fidelity. Sci Adv. 8(44):eabo7247

Song, K., Yang, X., An, G (...) Liu, Z., Zhao, XY. (2022). Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models. Nat Commun. 13(1):7335

Zhu, R., Canena, D., Sikora, M (...) Hummer, G., Hinterdorfer, P. (2022). Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nat Commun. 13(1):7926

Fell, CW., Hagelkruys, A., Cicvaric, A (...) Penninger, JM., Nagy, V. (2022). FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder. EMBO Mol Med. 14(9):e15829

Wang, J., An, M., Haubner, BJ., Penninger, JM. (2022). Cardiac regeneration: Options for repairing the injured heart. Front Cardiovasc Med. 9:981982

Capraz, T., Kienzl, NF., Laurent, E (...) Oostenbrink, C., Stadlmann, J. (2021). Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor. Elife. 10

Ooshio, T., Yamamoto, M., Fujii, K (...) Nishina, H., Nishikawa, Y. (2021). Hepatocyte Mitogen-Activated Protein Kinase Kinase 7 Contributes to Restoration of the Liver Parenchyma Following Injury in Mice. Hepatology. 73(6):2510-2526

Turgu, B., Zhang, F., El-Naggar, A (...) Hughes, CS., Sorensen, PH. (2021). HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner. Oncogene. 40(11):1988-2001

Hasan Ali, O., Bomze, D., Risch, L (...) Penninger, JM., Flatz, L. (2021). Erratum to: Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies. Clin Infect Dis.

Wirnsberger, G., Monteil, V., Eaton, B (...) Mirazimi, A., Penninger, JM. (2021). Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants. bioRxiv.

Shoemaker, RH., Panettieri, RA., Libutti, SK (...) Penninger, JM., Wirnsberger, G. (2021). Development of a novel, pan-variant aerosol intervention for COVID-19. bioRxiv.

Klionsky, DJ., Petroni, G., Amaravadi, RK (...) Galluzzi, L., Pietrocola, F. (2021). Autophagy in major human diseases. EMBO J. :e108863

Kokotović, T., Langeslag, M., Lenartowicz, EM (...) Penninger, JM., Nagy, V. (2021). PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life. Front Mol Neurosci. 14:720973

Kawahara, R., Chernykh, A., Alagesan, K (...) Packer, NH., Thaysen-Andersen, M. (2021). Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. Nat Methods. 18(11):1304-1316

Gomez-Diaz, C., Jonsson, G., Schodl, K (...) Penninger, JM., Ikeda, F. (2021). The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains. iScience. 24(11):103241

Ctortecka, C., Krššáková, G., Stejskal, K (...) Mechtler, K., Stadlmann, J. (2021). Comparative proteome signatures of trace samples by multiplexed Data-Independent Acquisition. Mol Cell Proteomics. :100177

Yamaguchi, T., Hoshizaki, M., Minato, T (...) Imai, Y., Kuba, K. (2021). ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury. Nat Commun. 12(1):6791

Kawahara, R., Chernykh, A., Alagesan, K (...) Packer, NH., Thaysen-Andersen, M. (2021). Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. Nat Methods.

Kuba, K., Yamaguchi, T., Penninger, JM. (2021). Angiotensin-Converting Enzyme 2 (ACE2) in the Pathogenesis of ARDS in COVID-19. Front Immunol. 12:732690

Morisaki, I., Shiraishi, H., Fujinami, H (...) Fujiki, M., Hanada, T. (2021). Modeling a human CLP1 mutation in mouse identifies an accumulation of tyrosine pre-tRNA fragments causing pontocerebellar hypoplasia type 10. Biochem Biophys Res Commun. 570:60-66

Penninger, JM., Grant, MB., Sung, JJY. (2021). The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection. Gastroenterology. 160(1):39-46

Asanović, I., Strandback, E., Kroupova, A (...) Weitzer, S., Martinez, J. (2021). The oxidoreductase PYROXD1 uses NAD(P)<sup>+</sup> as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response. Mol Cell. 81(12):2520-2532.e16

Stebbing, J., Sánchez Nievas, G., Falcone, M (...) Abizanda, P., Lauschke, VM. (2021). JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. Sci Adv. 7(1)

Onji, M., Werschler, N., Penninger, J. (2021). A critical relationship between bone and fat: the role of bone marrow adipose-derived RANKL in bone metabolism. EMBO Rep. 22(7):e52986

Ajoolabady, A., Wang, S., Kroemer, G (...) Klionsky, DJ., Ren, J. (2021). Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics. Pharmacol Ther. 225:107848

Olie, CS., van der Wal, E., Cikes, D (...) Kessler, BM., Raz, V. (2021). Author Correction: Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability. Sci Rep. 11(1):6429

Hagelkruys, A., Wirnsberger, G., Stadlmann, J (...) Klein, C., Penninger, JM. (2021). A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans. J Exp Med. 218(1)

Shin, T., Hiraoka, Y., Yamasaki, T (...) Kofuji, S., Nishina, H. (2021). MKK7 deficiency in mature neurons impairs parental behavior in mice. Genes Cells. 26(1):5-17

Hoffmann, D., Mereiter, S., Jin Oh, Y (...) Hinterdorfer, P., Penninger, JM. (2021). Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites. EMBO J. :e108375

Monteil, V., Dyczynski, M., Lauschke, VM (...) Penninger, JM., Mirazimi, A. (2021). Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection. EMBO Mol Med. 13(1):e13426

Ajoolabady, A., Aslkhodapasandhokmabad, H., Libby, P (...) Kroemer, G., Ren, J. (2021). Ferritinophagy and ferroptosis in the management of metabolic diseases. Trends Endocrinol Metab. 32(7):444-462

Mischkulnig, M., Kiesel, B., Lötsch, D (...) Widhalm, G., Erhart, F. (2021). Heme Biosynthesis mRNA Expression Signature: Towards a Novel Prognostic Biomarker in Patients with Diffusely Infiltrating Gliomas. Cancers (Basel). 13(4)

Hasan Ali, O., Bomze, D., Risch, L (...) Penninger, JM., Flatz, L. (2021). Severe Coronavirus Disease 2019 (COVID-19) is Associated With Elevated Serum Immunoglobulin (Ig) A and Antiphospholipid IgA Antibodies. Clin Infect Dis. 73(9):e2869-e2874

Paolino, M., Koglgruber, R., Cronin, SJF (...) Kautzky-Willer, A., Penninger, JM. (2021). RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy. Nature. 589(7842):442-447

Openshaw, RL., Thomson, DM., Thompson, R (...) Morris, BJ., Dawson, N. (2020). Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia. Schizophr Bull. 46(1):211-223

Zoufaly, A., Poglitsch, M., Aberle, JH (...) Slutsky, AS., Penninger, JM. (2020). Human recombinant soluble ACE2 in severe COVID-19. Lancet Respir Med. 8(11):1154-1158

Zhang, H., Penninger, JM., Li, Y., Zhong, N., Slutsky, AS. (2020). Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 46(4):586-590

Appelberg, S., Gupta, S., Svensson Akusjärvi, S (...) Mirazimi, A., Neogi, U. (2020). Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Emerg Microbes Infect. 9(1):1748-1760

Fennell, LM., Gomez Diaz, C., Deszcz, L (...) Penninger, J., Ikeda, F. (2020). Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling. EMBO J. 39(24):e103303

Inoue, M., Hada, K., Shiraishi, H (...) Ihara, K., Hanada, T. (2020). Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2. Biochem Biophys Res Commun. 525(3):726-732

Nitta, T., Tsutsumi, M., Nitta, S (...) Penninger, JM., Takayanagi, H. (2020). Fibroblasts as a source of self-antigens for central immune tolerance. Nat Immunol. 21(10):1172-1180

Tsukasaki, M., Huynh, NC., Okamoto, K (...) Penninger, JM., Takayanagi, H. (2020). Stepwise cell fate decision pathways during osteoclastogenesis at single-cell resolution. Nat Metab. 2(12):1382-1390

Gómez-Aleza, C., Nguyen, B., Yoldi, G (...) Sotiriou, C., González-Suárez, E. (2020). Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells. Nat Commun. 11(1):6335

Andergassen, D., Muckenhuber, M., Bammer, PC (...) Pauler, FM., Hudson, QJ. (2020). Correction: The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes. PLoS Genet. 16(10):e1009151

Olie, CS., van der Wal, E., Cikes, D (...) Kessler, BM., Raz, V. (2020). Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability. Sci Rep. 10(1):17621

Ni, J., Yang, F., Huang, XR (...) Yu, XQ., Lan, HY. (2020). Dual deficiency of angiotensin-converting enzyme-2 and Mas receptor enhances angiotensin II-induced hypertension and hypertensive nephropathy. J Cell Mol Med. 24(22):13093-13103

Koide, M., Yamashita, T., Murakami, K (...) Udagawa, N., Kobayashi, Y. (2020). Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep. 10(1):13751

Chabloz, A., Schaefer, JV., Kozieradzki, I (...) Marlovits, TC., Penninger, JM. (2020). Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol. Commun Biol. 3(1):342

Orthofer, M., Valsesia, A., Mägi, R (...) Gheldof, N., Penninger, JM. (2020). Identification of ALK in Thinness. Cell. 181(6):1246-1262.e22

Kogler, M., Tortola, L., Negri, GL (...) Sorensen, PH., Penninger, JM. (2020). HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases. Cancer Res. 80(14):3009-3022

Szoták-Ajtay, K., Szõke, D., Kovács, G (...) Kahn, ML., Jakus, Z. (2020). Reduced Prenatal Pulmonary Lymphatic Function Is Observed in <i>Clp1</i> <sup><i>K/K</i></sup> Embryos With Impaired Motor Functions Including Fetal Breathing Movements in Preparation of the Developing Lung for Inflation at Birth. Front Bioeng Biotechnol. 8:136

Wunderle, M., Ruebner, M., Häberle, L (...) Schneider, MO., Fasching, PA. (2020). RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women. Sci Rep. 10(1):5171

Minato, T., Nirasawa, S., Sato, T (...) Takahashi, S., Kuba, K. (2020). B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Nat Commun. 11(1):1058

Fujinami, H., Shiraishi, H., Hada, K (...) Mimata, H., Hanada, T. (2020). CLP1 acts as the main RNA kinase in mice. Biochem Biophys Res Commun.

Beveridge, R., Stadlmann, J., Penninger, JM., Mechtler, K. (2020). A synthetic peptide library for benchmarking crosslinking-mass spectrometry search engines for proteins and protein complexes. Nat Commun. 11(1):742

Li, T., Li, K., Zhang, S (...) Blomgren, K., Zhu, C. (2020). Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice. Cell Death Dis. 11(1):77

Ming, J., Cronin, SJF., Penninger, JM. (2020). Targeting the RANKL/RANK/OPG Axis for Cancer Therapy. Front Oncol. 10:1283

Monteil, V., Kwon, H., Prado, P (...) Mirazimi, A., Penninger, JM. (2020). Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell. 181(4):905-913.e7

Bravo-Caparrós, I., Ruiz-Cantero, MC., Perazzoli, G (...) Cobos, EJ., Nieto, FR. (2020). Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury. FASEB J. 34(4):5951-5966

Wolle, P., Hardick, J., Cronin, SJF (...) Penninger, JM., Rauh, D. (2019). Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors. J Med Chem. 62(5):2843-2848

Wimmer, RA., Leopoldi, A., Aichinger, M., Kerjaschki, D., Penninger, JM. (2019). Generation of blood vessel organoids from human pluripotent stem cells. Nat Protoc. 14(11):3082-3100

Cronin, SJF., Seehus, C., Weidinger, A (...) Woolf, CJ., Penninger, JM. (2019). Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 572(7769):E18

Landmann, J., Richter, F., Classen, J (...) Penninger, JM., Bechmann, I. (2019). Behavioral phenotyping of calcium channel (CACN) subunit α2δ3 knockout mice: Consequences of sensory cross-modal activation. Behav Brain Res. 364:393-402

Wang, W., Shen, M., Fischer, C (...) Kassiri, Z., Oudit, GY. (2019). Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proc Natl Acad Sci U S A. 116(26):13006-13015

Elling, U., Woods, M., Forment, JV (...) Penninger, JM., Balmus, G. (2019). Derivation and maintenance of mouse haploid embryonic stem cells. Nat Protoc. 14(7):1991-2014

Cronin, SJF., Woolf, CJ., Weiss, G., Penninger, JM. (2019). The Role of Iron Regulation in Immunometabolism and Immune-Related Disease. Front Mol Biosci. 6:116

Stadlmann, J., Hudecz, O., Krššáková, G (...) Jacobs, P., Mechtler, K. (2019). Improved Sensitivity in Low-Input Proteomics Using Micropillar Array-Based Chromatography. Anal Chem. 91(22):14203-14207

Andergassen, D., Muckenhuber, M., Bammer, PC (...) Pauler, FM., Hudson, QJ. (2019). The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes. PLoS Genet. 15(7):e1008268

Nagy, V., Hollstein, R., Pai, TP (...) Kaiser, FJ., Penninger, JM. (2019). HACE1 deficiency leads to structural and functional neurodevelopmental defects. Neurol Genet. 5(3):e330

Openshaw, RL., Kwon, J., McColl, A (...) Pratt, JA., Morris, BJ. (2019). JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. J Neuroinflammation. 16(1):18

Ang, CE., Ma, Q., Wapinski, OL (...) Wernig, M., Chang, HY. (2019). The novel lncRNA <i>lnc-NR2F1</i> is pro-neurogenic and mutated in human neurodevelopmental disorders. Elife. 8

Fujiwara, S., Hoshizaki, M., Ichida, Y (...) Kuba, K., Imai, Y. (2019). Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. Nat Microbiol. 4(2):258-268

Uribesalgo, I., Hoffmann, D., Zhang, Y (...) Haubner, BJ., Penninger, JM. (2019). Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy. EMBO Mol Med. 11(8):e9266

Rao, S., Mondragón, L., Pranjic, B (...) Kroemer, G., Penninger, JM. (2019). AIF-regulated oxidative phosphorylation supports lung cancer development. Cell Res. 29(7):579-591

Mastrella, G., Hou, M., Li, M (...) Glass, R., Kälin, RE. (2019). Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma. Cancer Res. 79(9):2298-2313

Wimmer, RA., Leopoldi, A., Aichinger, M (...) Kerjaschki, D., Penninger, JM. (2019). Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 565(7740):505-510

Lee, NJ., Clarke, IM., Zengin, A (...) Baldock, PA., Herzog, H. (2019). RANK deletion in neuropeptide Y neurones attenuates oestrogen deficiency-related bone loss. J Neuroendocrinol. 31(2):e12687

Haubner, BJ., Schuetz, T., Penninger, JM. (2018). Cardiac regeneration in a newborn: what does this mean for future cardiac repair research? Expert Rev Cardiovasc Ther. 16(3):155-157

Timper, K., Paeger, L., Sánchez-Lasheras, C (...) Kloppenburg, P., Brüning, JC. (2018). Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Rep. 25(2):383-397.e10

Landmann, J., Richter, F., Oros-Peusquens, AM (...) Penninger, JM., Bechmann, I. (2018). Neuroanatomy of pain-deficiency and cross-modal activation in calcium channel subunit (CACN) α2δ3 knockout mice. Brain Struct Funct. 223(1):111-130

Moll, HP., Pranz, K., Musteanu, M (...) Popper, H., Casanova, E. (2018). Afatinib restrains K-RAS-driven lung tumorigenesis. Sci Transl Med. 10(446)

Klempin, F., Mosienko, V., Matthes, S (...) Santos, RAS., Alenina, N. (2018). Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response. Cell Mol Life Sci. 75(19):3625-3634

Sasaki, F., Koga, T., Ohba, M (...) Sonoda, KH., Yokomizo, T. (2018). Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models. JCI Insight. 3(18)

Szappanos, D., Tschismarov, R., Perlot, T (...) Penninger, JM., Decker, T. (2018). The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity. PLoS Pathog. 14(11):e1007397

Zoranovic, T., Manent, J., Willoughby, L (...) Richardson, HE., Penninger, JM. (2018). A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer. PLoS Genet. 14(10):e1007688

Singh, TP., Vieyra-Garcia, PA., Wagner, K., Penninger, J., Wolf, P. (2018). Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature. Cell Death Dis. 9(8):835

Dufresne, SS., Boulanger-Piette, A., Bossé, S (...) Russell Tupling, A., Frenette, J. (2018). Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy. Acta Neuropathol Commun. 6(1):31

Horn, M., Kroef, V., Allmeroth, K (...) Elling, U., Denzel, MS. (2018). Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells. Oncotarget. 9(11):9838-9851

Yamaguchi, T., Suzuki, T., Sato, T (...) Imai, Y., Kuba, K. (2018). The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Sci Signal. 11(516)

Stadlmann, J., Hoi, DM., Taubenschmid, J., Mechtler, K., Penninger, JM. (2018). Analysis of PNGase F-Resistant N-Glycopeptides Using SugarQb for Proteome Discoverer 2.1 Reveals Cryptic Substrate Specificities. Proteomics. 18(13):e1700436

Cronin, SJF., Seehus, C., Weidinger, A (...) Woolf, CJ., Penninger, JM. (2018). The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 563(7732):564-568

Ikebuchi, Y., Aoki, S., Honma, M (...) Aoki, K., Suzuki, H. (2018). Coupling of bone resorption and formation by RANKL reverse signalling. Nature. 561(7722):195-200

Stephen, J., Nampoothiri, S., Banerjee, A (...) Gahl, WA., Malicdan, MCV. (2018). Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy. Hum Genet. 137(4):293-303

Lee, NJ., Clarke, IM., Enriquez, RF (...) Baldock, PA., Herzog, H. (2018). Central RANK signalling in NPY neurons alters bone mass in male mice. Neuropeptides. 68:75-83

Galluzzi, L., Vitale, I., Aaronson, SA (...) Melino, G., Kroemer, G. (2018). Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 25(3):486-541

Rao, S., Cronin, SJF., Sigl, V., Penninger, JM. (2018). RANKL and RANK: From Mammalian Physiology to Cancer Treatment. Trends Cell Biol. 28(3):213-223

Ganglberger, F., Kaczanowska, J., Penninger, JM (...) Bühler, K., Haubensak, W. (2018). Predicting functional neuroanatomical maps from fusing brain networks with genetic information. Neuroimage. 170:113-120

Tran, CW., Saibil, SD., Le Bihan, T (...) Mak, TW., Ohashi, PS. (2017). Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. J Immunol. 199(12):4056-4065

Zhang, ZZ., Wang, W., Jin, HY (...) Oudit, GY., Zhong, JC. (2017). Apelin Is a Negative Regulator of Angiotensin II-Mediated Adverse Myocardial Remodeling and Dysfunction. Hypertension. 70(6):1165-1175

Stadlmann, J., Taubenschmid, J., Wenzel, D (...) Mechtler, K., Penninger, JM. (2017). Comparative glycoproteomics of stem cells identifies new players in ricin toxicity. Nature. 549(7673):538-542

Elling, U., Wimmer, RA., Leibbrandt, A (...) Stark, A., Penninger, JM. (2017). A reversible haploid mouse embryonic stem cell biobank resource for functional genomics. Nature. 550(7674):114-118

Taubenschmid, J., Stadlmann, J., Jost, M (...) Koerner, C., Penninger, JM. (2017). A vital sugar code for ricin toxicity. Cell Res. 27(11):1351-1364

Manent, J., Banerjee, S., de Matos Simoes, R (...) Humbert, PO., Richardson, HE. (2017). Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species. Oncogene. 36(40):5576-5592

Tsukasaki, M., Hamada, K., Okamoto, K (...) Penninger, JM., Takayanagi, H. (2017). LOX Fails to Substitute for RANKL in Osteoclastogenesis. J Bone Miner Res. 32(3):434-439

Papanikos, F., Daniel, K., Goercharn-Ramlal, A (...) Stewart, AF., Toth, A. (2017). The enigmatic meiotic dense body and its newly discovered component, SCML1, are dispensable for fertility and gametogenesis in mice. Chromosoma. 126(3):399-415

Habbeddine, M., Verthuy, C., Rastoin, O (...) Penninger, JM., Lawrence, T. (2017). Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone. Cell Rep. 21(9):2515-2527

Sato, T., Sato, C., Kadowaki, A (...) Imai, Y., Kuba, K. (2017). ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. Cardiovasc Res. 113(7):760-769

Openshaw, RL., Thomson, DM., Penninger, JM., Pratt, JA., Morris, BJ. (2017). Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline. Psychopharmacology (Berl). 234(2):293-305

Kiechl, S., Schramek, D., Widschwendter, M (...) Schett, G., Penninger, JM. (2017). Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer. Oncotarget. 8(3):3811-3825

Schneider, C., Nobs, SP., Heer, AK (...) Siggs, OM., Kopf, M. (2017). Frontline Science: Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection. J Leukoc Biol. 101(2):367-376

Galluzzi, L., Baehrecke, EH., Ballabio, A (...) Zhong, Q., Kroemer, G. (2017). Molecular definitions of autophagy and related processes. EMBO J. 36(13):1811-1836

Nagashima, K., Sawa, S., Nitta, T (...) Nakashima, T., Takayanagi, H. (2017). Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nat Immunol. 18(6):675-682

Manent, J., Banerjee, S., de Matos Simoes, R (...) Humbert, PO., Richardson, HE. (2017). Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species. Oncogene. 36(40):5658-5660

Rao, S., Sigl, V., Wimmer, RA (...) Dougall, W., Penninger, JM. (2017). RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer. Genes Dev. 31(20):2099-2112

Andergassen, D., Dotter, CP., Wenzel, D (...) Pauler, FM., Hudson, QJ. (2017). Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. Elife. 6

Yamasaki, T., Deki-Arima, N., Kaneko, A (...) Shibata, S., Nishina, H. (2017). Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Sci Rep. 7(1):7348

Tejada, MA., Montilla-García, A., Cronin, SJ (...) Baeyens, JM., Cobos, EJ. (2017). Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice. Proc Natl Acad Sci U S A. 114(31):8396-8401

Klionsky, DJ., Abdelmohsen, K., Abe, A (...) Zorzano, A., Zughaier, SM. (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12(1):1-222

van der Harst, P., van Setten, J., Verweij, N (...) Samani, NJ., de Bakker, PIW. (2016). 52 Genetic Loci Influencing Myocardial Mass. J Am Coll Cardiol. 68(13):1435-1448

Einwallner, E., Kiefer, FW., Di Caro, G (...) Esterbauer, H., Todoric, J. (2016). Mast cells are not associated with systemic insulin resistance. Eur J Clin Invest. 46(11):911-919

Nunes-Souza, V., Alenina, N., Qadri, F (...) Bader, M., Rabelo, LA. (2016). CD36/Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice. Oxid Med Cell Longev. 2016:6487509

Dufresne, SS., Dumont, NA., Boulanger-Piette, A (...) Tupling, AR., Frenette, J. (2016). Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles. Am J Physiol Cell Physiol. 310(8):C663-72

Dalgaard, K., Landgraf, K., Heyne, S (...) Körner, A., Pospisilik, JA. (2016). Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell. 164(3):353-64

Valent, P., Groner, B., Schumacher, U (...) Müller, M., Sörgel, F. (2016). Paul Ehrlich (1854-1915) and His Contributions to the Foundation and Birth of Translational Medicine. J Innate Immun. 8(2):111-20

Polizzotti, BD., Ganapathy, B., Haubner, BJ., Penninger, JM., Kühn, B. (2016). A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nat Protoc. 11(3):542-52

Tortola, L., Nitsch, R., Penninger, JM. (2016). TNF-driven cell fate: till HACE do us part. Oncotarget. 7(29):44871-44872

Sigl, V., Jones, LP., Penninger, JM. (2016). RANKL/RANK: from bone loss to the prevention of breast cancer. Open Biol. 6(11)

Patel, VB., Mori, J., McLean, BA (...) Lopaschuk, GD., Oudit, GY. (2016). ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. Diabetes. 65(1):85-95

Pietrocola, F., Pol, J., Vacchelli, E (...) Penninger, JM., Kroemer, G. (2016). Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance. Cancer Cell. 30(1):147-160

Wang, QP., Lin, YQ., Zhang, L (...) Herzog, H., Neely, GG. (2016). Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response. Cell Metab. 24(1):75-90

Haubner, BJ., Schuetz, T., Penninger, JM. (2016). A reproducible protocol for neonatal ischemic injury and cardiac regeneration in neonatal mice. Basic Res Cardiol. 111(6):64

Sigl, V., Owusu-Boaitey, K., Joshi, PA (...) Jones, LP., Penninger, JM. (2016). RANKL/RANK control Brca1 mutation- . Cell Res. 26(7):761-74

Tortola, L., Nitsch, R., Bertrand, MJM (...) Sorensen, PH., Penninger, JM. (2016). The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 15(7):1481-1492

Luo, J., Yang, Z., Ma, Y (...) Xiao, J., Liu, M. (2016). LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nat Med. 22(5):539-46

Okamoto-Uchida, Y., Yu, R., Miyamura, N (...) Azuma, N., Nishina, H. (2016). The mevalonate pathway regulates primitive streak formation via protein farnesylation. Sci Rep. 6:37697

Paolino, M., Penninger, JM. (2016). The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy. Cancers (Basel). 8(10)

Andritschke, D., Dilling, S., Emmenlauer, M (...) Dehio, C., Hardt, WD. (2016). A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion. PLoS One. 11(9):e0161965

Rabelo, LA., Todiras, M., Nunes-Souza, V (...) Santos, RA., Alenina, N. (2016). Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress. PLoS One. 11(4):e0150255

Iwamoto, Y., Nishikawa, K., Imai, R (...) Inohara, H., Ishii, M. (2016). Intercellular Communication between Keratinocytes and Fibroblasts Induces Local Osteoclast Differentiation: a Mechanism Underlying Cholesteatoma-Induced Bone Destruction. Mol Cell Biol. 36(11):1610-20

Tortola, L., Nitsch, R., Bertrand, MJM (...) Sorensen, PH., Penninger, JM. (2016). The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 16(12):3414

Wirnsberger, G., Zwolanek, F., Asaoka, T (...) Kuchler, K., Penninger, JM. (2016). Inhibition of CBLB protects from lethal Candida albicans sepsis. Nat Med. 22(8):915-23

Akiyama, N., Takizawa, N., Miyauchi, M (...) Inoue, J., Akiyama, T. (2016). Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. J Exp Med. 213(8):1441-58

Motta-Santos, D., Dos Santos, RA., Oliveira, M (...) Alenina, N., Bader, M. (2016). Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise. Hypertens Res. 39(7):506-12

Haubner, BJ., Schneider, J., Schweigmann, U (...) Stein, JI., Penninger, JM. (2016). Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction. Circ Res. 118(2):216-21

Lempradl, A., Pospisilik, JA., Penninger, JM. (2015). Exploring the emerging complexity in transcriptional regulation of energy homeostasis. Nat Rev Genet. 16(11):665-81

Heier, C., Radner, FP., Moustafa, T (...) Zimmermann, R., Zechner, R. (2015). G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis. J Biol Chem. 290(43):26141-50

Greenblatt, MB., Park, KH., Oh, H (...) Ghosh, S., Shim, JH. (2015). CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts. J Exp Med. 212(8):1283-301

Kondegowda, NG., Fenutria, R., Pollack, IR (...) Penninger, JM., Vasavada, RC. (2015). Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway. Cell Metab. 22(1):77-85

Kulinski, TM., Casari, MR., Guenzl, PM (...) Barlow, DP., Hudson, QJ. (2015). Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 402(2):291-305

Dufresne, SS., Dumont, NA., Bouchard, P (...) Penninger, JM., Frenette, J. (2015). Osteoprotegerin protects against muscular dystrophy. Am J Pathol. 185(4):920-6

Galluzzi, L., Bravo-San Pedro, JM., Vitale, I (...) Melino, G., Kroemer, G. (2015). Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ. 22(1):58-73

Latremoliere, A., Latini, A., Andrews, N (...) Costigan, M., Woolf, CJ. (2015). Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. 86(6):1393-406

Talbot, S., Abdulnour, RE., Burkett, PR (...) Levy, BD., Woolf, CJ. (2015). Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 87(2):341-54

Joshi, PA., Waterhouse, PD., Kannan, N (...) Eaves, C., Khokha, R. (2015). RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5(1):31-44

Polizzotti, BD., Ganapathy, B., Walsh, S (...) Penninger, JM., Kühn, B. (2015). Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Sci Transl Med. 7(281):281ra45

Cheloufi, S., Elling, U., Hopfgartner, B (...) Zuber, J., Hochedlinger, K. (2015). The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 528(7581):218-24

Guerrini, MM., Okamoto, K., Komatsu, N (...) Nakashima, T., Takayanagi, H. (2015). Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System. Immunity. 43(6):1174-85

Nagy, V., Penninger, JM. (2015). The RANKL-RANK Story. Gerontology. 61(6):534-42

Nakajima, KI., Zhu, K., Sun, YH (...) Penninger, JM., Zhao, M. (2015). KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun. 6:8532

Tsvetkov, P., Mendillo, ML., Zhao, J (...) Santagata, S., Lindquist, S. (2015). Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife. 4

Sun, Y., Guo, F., Zou, Z (...) Penninger, JM., Jiang, C. (2015). Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. Part Fibre Toxicol. 12:4

Grabner, B., Schramek, D., Mueller, KM (...) Popper, H., Casanova, E. (2015). Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nat Commun. 6:6285

Galluzzi, L., Pietrocola, F., Bravo-San Pedro, JM (...) Ryan, KM., Kroemer, G. (2015). Autophagy in malignant transformation and cancer progression. EMBO J. 34(7):856-80

Chen, Y., Di Grappa, MA., Molyneux, SD (...) Penninger, JM., Khokha, R. (2015). RANKL blockade prevents and treats aggressive osteosarcomas. Sci Transl Med. 7(317):317ra197

Nagy, V., Cole, T., Van Campenhout, C (...) Neely, GG., Penninger, JM. (2015). The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle. 14(12):1799-808

Schuetz T, Kuehn B, Penninger JM, Haubner BJ (2015). Direct comparison of ischemic- vs. cryoinjury in the neonatal mouse heart. Wiener Klinische Wochenschrift. (127):9-10

Weitzer, S., Hanada, T., Penninger, JM., Martinez, J. (2015). CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders. Wiley Interdiscip Rev RNA. 6(1):47-63

Boztug, K., Järvinen, PM., Salzer, E (...) Donadieu, J., Klein, C. (2014). JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Nat Genet. 46(9):1021-7

Karaca, E., Weitzer, S., Pehlivan, D (...) Penninger, JM., Lupski, JR. (2014). Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function. Cell. 157(3):636-50

Sigl, V., Penninger, JM. (2014). RANKL/RANK - from bone physiology to breast cancer. Cytokine Growth Factor Rev. 25(2):205-14

Wang, W., Patel, VB., Parajuli, N (...) Penninger, JM., Oudit, GY. (2014). Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease. J Mol Med (Berl). 92(8):847-58

Paolino, M., Choidas, A., Wallner, S (...) Klebl, BM., Penninger, JM. (2014). The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 507(7493):508-12

Rotblat, B., Southwell, AL., Ehrnhoefer, DE (...) Hayden, MR., Sorensen, PH. (2014). HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. Proc Natl Acad Sci U S A. 111(8):3032-7

Kotsinas, A., Papanagnou, P., Galanos, P (...) Bartek, J., Gorgoulis, VG. (2014). MKK7 and ARF: new players in the DNA damage response scenery. Cell Cycle. 13(8):1227-36

Rao, S., Tortola, L., Perlot, T (...) Kroemer, G., Penninger, JM. (2014). A dual role for autophagy in a murine model of lung cancer. Nat Commun. 5:3056

Qiao, G., Ying, H., Zhao, Y (...) Langdon, WY., Zhang, J. (2014). E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Rep. 6(4):709-23

Itoh, T., Horiuchi, M., Ikeda, RH (...) Tournier, C., Itoh, A. (2014). ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J Neurosci. 34(32):10729-42

Elling, U., Penninger, JM. (2014). Genome wide functional genetics in haploid cells. FEBS Lett. 588(15):2415-21

Rao, S., Yang, H., Penninger, JM., Kroemer, G. (2014). Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance. Autophagy. 10(3):529-31

Wirnsberger, G., Zwolanek, F., Stadlmann, J (...) Elling, U., Penninger, JM. (2014). Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Nat Genet. 46(9):1028-33

Wenzel, D., Bayerl, J., Nyström, A (...) Meixner, A., Penninger, JM. (2014). Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa. Sci Transl Med. 6(264):264ra165

Huang, F., Guo, J., Zou, Z (...) Jiang, C., Li, L. (2014). Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nat Commun. 5:3595

Yang, P., Gu, H., Zhao, Z (...) Jiang, C., Wang, X. (2014). Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Sci Rep. 4:7027

Zou, Z., Yan, Y., Shu, Y (...) Penninger, JM., Jiang, C. (2014). Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nat Commun. 5:3594

Zhang, L., Chen, X., Sharma, P (...) Brumell, JH., Liu, PP. (2014). HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nat Commun. 5:3430

Morita, M., Kuba, K., Ichikawa, A (...) Arita, M., Imai, Y. (2013). The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell. 153(1):112-25

Lee, HJ., Gallego-Ortega, D., Ledger, A (...) Penninger, JM., Ormandy, CJ. (2013). Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development. 140(7):1397-401

Wang, W., Yang, P., Zhong, Y (...) Wang, X., Jiang, C. (2013). Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury. Cell Res. 23(4):577-80

Jux, B., Staratschek-Jox, A., Penninger, JM., Schultze, JL., Kolanus, W. (2013). Vav1 regulates MHCII expression in murine resting and activated B cells. Int Immunol. 25(5):307-17

Furuya, Y., Inagaki, A., Khan, M (...) Uchida, K., Yasuda, H. (2013). Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity. J Biol Chem. 288(8):5562-71

Perlot, T., Penninger, JM. (2013). ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition. Microbes Infect. 15(13):866-73

Fielding, RA., Gunstad, J., Gustafson, DR (...) Phillips, DI., Scarmeas, N. (2013). The paradox of overnutrition in aging and cognition. Ann N Y Acad Sci. 1287:31-43

Paul, DS., Albers, CA., Rendon, A (...) Ouwehand, WH., Deloukas, P. (2013). Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Res. 23(7):1130-41

Badger-Brown, KM., Gillis, LC., Bailey, ML., Penninger, JM., Barber, DL. (2013). CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing. Leukemia. 27(5):1146-54

Offord, EA., Karagounis, LG., Vidal, K (...) Meydani, S., Penninger, JM. (2013). Nutrition and the biology of human ageing: bone health and osteoporosis / sarcopenia / immune deficiency. J Nutr Health Aging. 17(8):712-6

Haschke, M., Schuster, M., Poglitsch, M (...) Penninger, J., Krähenbühl, S. (2013). Pharmacokinetics and pharmacodynamics of recombinant human angiotensin-converting enzyme 2 in healthy human subjects. Clin Pharmacokinet. 52(9):783-92

Zhang, ZZ., Shang, QH., Jin, HY (...) Penninger, JM., Zhong, JC. (2013). Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. J Transl Med. 11:229

Wang, W., McKinnie, SM., Patel, VB (...) Murray, AG., Oudit, GY. (2013). Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc. 2(4):e000249

Wallner, S., Lutz-Nicoladoni, C., Tripp, CH (...) Stoitzner, P., Wolf, D. (2013). The role of the e3 ligase cbl-B in murine dendritic cells. PLoS One. 8(6):e65178

Raith, M., Valencia, RG., Fischer, I (...) Rezniczek, GA., Wiche, G. (2013). Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers. Skelet Muscle. 3(1):14

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Daugaard, M., Nitsch, R., Razaghi, B (...) Penninger, JM., Sorensen, PH. (2013). Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nat Commun. 4:2180

Song, B., Jin, H., Yu, X (...) Penninger, JM., Zhong, JC. (2013). Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. Regul Pept. 185:44-51

Hanada, T., Weitzer, S., Mair, B (...) Martinez, J., Penninger, JM. (2013). CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 495(7442):474-80

Kiechl, S., Wittmann, J., Giaccari, A (...) Willeit, J., Schett, G. (2013). Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med. 19(3):358-63

Kuba, K., Imai, Y., Penninger, JM. (2013). Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases. Circ J. 77(2):301-8

Ichikawa, A., Kuba, K., Morita, M (...) Slutsky, AS., Imai, Y. (2013). CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med. 187(1):65-77

Wöhrle, FU., Halbach, S., Aumann, K (...) Daly, RJ., Brummer, T. (2013). Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors. Leukemia. 27(1):118-29

Lo, J., Patel, VB., Wang, Z (...) Penninger, JM., Oudit, GY. (2013). Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats. Exp Physiol. 98(1):109-22

Neely, GG., Rao, S., Costigan, M (...) Woolf, CJ., Penninger, JM. (2012). Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet. 8(12):e1003071

Peña Silva, RA., Chu, Y., Miller, JD (...) Faraci, FM., Heistad, DD. (2012). Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke. 43(12):3358-63

Hinterleitner, R., Gruber, T., Pfeifhofer-Obermair, C (...) Wolf, D., Baier, G. (2012). Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model. PLoS One. 7(9):e44295

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Qi, Y., Tian, X., Liu, J (...) Carmeliet, P., Li, S. (2012). Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. J Cell Biol. 198(1):103-14

Jin, HY., Song, B., Oudit, GY (...) Penninger, JM., Zhong, JC. (2012). ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. PLoS One. 7(6):e38502

Nakamichi, Y., Mizoguchi, T., Arai, A (...) Udagawa, N., Takahashi, N. (2012). Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice. Proc Natl Acad Sci U S A. 109(25):10006-11

Arai, A., Mizoguchi, T., Harada, S (...) Udagawa, N., Takahashi, N. (2012). Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment. J Cell Sci. 125(Pt 12):2910-7

Roberts, NA., White, AJ., Jenkinson, WE (...) Jenkinson, EJ., Anderson, G. (2012). Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium. Immunity. 36(3):427-37

Rey-Parra, GJ., Vadivel, A., Coltan, L (...) Oudit, GY., Thébaud, B. (2012). Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury. J Mol Med (Berl). 90(6):637-47

Attané, C., Foussal, C., Le Gonidec, S (...) Valet, P., Castan-Laurell, I. (2012). Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes. 61(2):310-20

Lutz-Nicoladoni, C., Wallner, S., Stoitzner, P (...) Baier, G., Wolf, D. (2012). Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine. Immunol Cell Biol. 90(1):130-4

Haubner, BJ., Adamowicz-Brice, M., Khadayate, S (...) Aitman, T., Penninger, JM. (2012). Complete cardiac regeneration in a mouse model of myocardial infarction. Aging (Albany NY). 4(12):966-77

Teperino, R., Amann, S., Bayer, M (...) Pospisilik, JA., Esterbauer, H. (2012). Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell. 151(2):414-26

Guo, H., Qiao, G., Ying, H (...) Langdon, WY., Zhang, J. (2012). E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Rep. 1(5):472-82

Kleinsasser, A., Pircher, I., Treml, B (...) Penninger, JM., Loeckinger, A. (2012). Recombinant angiotensin-converting enzyme 2 suppresses pulmonary vasoconstriction in acute hypoxia. Wilderness Environ Med. 23(1):24-30

Douni, E., Rinotas, V., Makrinou, E (...) Schett, G., Kollias, G. (2012). A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Hum Mol Genet. 21(4):784-98

Perlot, T., Penninger, JM. (2012). Development and function of murine B cells lacking RANK. J Immunol. 188(3):1201-5

Liu, Z., Huang, XR., Chen, HY., Penninger, JM., Lan, HY. (2012). Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy. Lab Invest. 92(5):650-61

Laimer, D., Dolznig, H., Kollmann, K (...) Inghirami, G., Kenner, L. (2012). PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nat Med. 18(11):1699-704

Winchester, CL., Ohzeki, H., Vouyiouklis, DA (...) Pratt, JA., Morris, BJ. (2012). Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia. Hum Mol Genet. 21(22):4910-21

van der Harst, P., Zhang, W., Mateo Leach, I (...) Soranzo, N., Chambers, JC. (2012). Seventy-five genetic loci influencing the human red blood cell. Nature. 492(7429):369-75

Desanti, GE., Cowan, JE., Baik, S (...) Jenkinson, WE., Anderson, G. (2012). Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla. J Immunol. 189(12):5519-26

Xiol, J., Cora, E., Koglgruber, R (...) Sachidanandam, R., Pillai, RS. (2012). A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Mol Cell. 47(6):970-9

Singer, D., Camargo, SM., Ramadan, T (...) Penninger, JM., Verrey, F. (2012). Defective intestinal amino acid absorption in Ace2 null mice. Am J Physiol Gastrointest Liver Physiol. 303(6):G686-95

Senovilla, L., Vitale, I., Martins, I (...) Castedo, M., Kroemer, G. (2012). An immunosurveillance mechanism controls cancer cell ploidy. Science. 337(6102):1678-84

Hashimoto, T., Perlot, T., Rehman, A (...) Rosenstiel, P., Penninger, JM. (2012). ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487(7408):477-81

Elling, U., Taubenschmid, J., Wirnsberger, G (...) Stark, A., Penninger, JM. (2011). Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell. 9(6):563-74

Hanada, R., Penninger, JM. (2011). [Central regulation of body temperature by RANKL/RANK pathway]. Clin Calcium. 21(8):1201-8

Kornfeld, JW., Isaacs, A., Vitart, V (...) Pramstaller, PP., Hicks, AA. (2011). Variants in STAT5B associate with serum TC and LDL-C levels. J Clin Endocrinol Metab. 96(9):E1496-501

Jin, R., Song, Z., Yu, S (...) Granger, DN., Li, G. (2011). Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke. Stroke. 42(7):2033-44

Bodiga, S., Zhong, JC., Wang, W (...) Kassiri, Z., Oudit, GY. (2011). Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. Cardiovasc Res. 91(1):151-61

Gieger, C., Radhakrishnan, A., Cvejic, A (...) Ouwehand, WH., Soranzo, N. (2011). New gene functions in megakaryopoiesis and platelet formation. Nature. 480(7376):201-8

Nakashima, T., Hayashi, M., Fukunaga, T (...) Penninger, JM., Takayanagi, H. (2011). Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med. 17(10):1231-4

Miyamoto, K., Yoshida, S., Kawasumi, M (...) Suda, T., Miyamoto, T. (2011). Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med. 208(11):2175-81

Lee, AW., Mao, Y., Penninger, JM., Yu, S. (2011). Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development. Mol Cell Biol. 31(22):4563-81

Neely, GG., Keene, AC., Duchek, P (...) Garrity, PA., Penninger, JM. (2011). TrpA1 regulates thermal nociception in Drosophila. PLoS One. 6(8):e24343

Koletar, MM., Cheng, HY., Penninger, JM., Ralph, MR. (2011). Loss of dexras1 alters nonphotic circadian phase shifts and reveals a role for the intergeniculate leaflet (IGL) in gene-targeted mice. Chronobiol Int. 28(7):553-62

Schramek, D., Sigl, V., Penninger, JM. (2011). RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis. Trends Endocrinol Metab. 22(5):188-94

Hanada, R., Hanada, T., Sigl, V., Schramek, D., Penninger, JM. (2011). RANKL/RANK-beyond bones. J Mol Med (Berl). 89(7):647-56

Duheron, V., Hess, E., Duval, M (...) Paus, R., Mueller, CG. (2011). Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit. Proc Natl Acad Sci U S A. 108(13):5342-7

Zhong, J., Guo, D., Chen, CB (...) Kassiri, Z., Oudit, GY. (2011). Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension. 57(2):314-22

Meng, X., Arocena, M., Penninger, J (...) Zhao, M., Song, B. (2011). PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Exp Neurol. 227(1):210-7

Oh, SY., Park, JU., Zheng, T (...) Penninger, J., Zhu, Z. (2011). Cbl-b regulates airway mucosal tolerance to aeroallergen. Clin Exp Allergy. 41(3):434-42

Yamasaki, T., Kawasaki, H., Arakawa, S (...) Katada, T., Nishina, H. (2011). Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J Neurosci. 31(46):16872-83

Muto, A., Mizoguchi, T., Udagawa, N (...) Noguchi, T., Takahashi, N. (2011). Lineage-committed osteoclast precursors circulate in blood and settle down into bone. J Bone Miner Res. 26(12):2978-90

Oudit, GY., Penninger, JM. (2011). Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy. Curr Heart Fail Rep. 8(3):176-83

Taschler, U., Radner, FP., Heier, C (...) Zechner, R., Zimmermann, R. (2011). Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem. 286(20):17467-77

Mouri, Y., Yano, M., Shinzawa, M (...) Akiyama, T., Matsumoto, M. (2011). Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. J Immunol. 186(9):5047-57

Kaminski, S., Hermann-Kleiter, N., Meisel, M (...) Penninger, JM., Baier, G. (2011). Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells. J Autoimmun. 37(3):198-208

Schramek, D., Kotsinas, A., Meixner, A (...) Gorgoulis, VG., Penninger, JM. (2011). The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet. 43(3):212-9

Leibbrandt, A., Penninger, JM. (2011). TNF conference 2009: beyond bones - RANKL/RANK in the immune system. Adv Exp Med Biol. 691:5-22

Paolino, M., Thien, CB., Gruber, T (...) Langdon, WY., Penninger, JM. (2011). Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions. J Immunol. 186(4):2138-47

Zhong, JC., Ye, JY., Jin, HY (...) Penninger, JM., Oudit, GY. (2011). Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression. Regul Pept. 166(1-3):90-7

Neely, GG., Kuba, K., Cammarato, A (...) Bodmer, R., Penninger, JM. (2010). A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 141(1):142-53

Xu, H., Su, Z., Wu, J (...) Kvietys, PR., Rui, T. (2010). The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. J Immunol. 184(3):1492-8

Fleuren, ED., O'Toole, S., Millar, EK (...) Sutherland, RL., Daly, RJ. (2010). Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development. Int J Cancer. 127(6):1486-92

Heindl-Erdmann, C., Axmann, R., Kreitz, S (...) Brune, K., Hess, A. (2010). Combining functional magnetic resonance imaging with mouse genomics: new options in pain research. Neuroreport. 21(1):29-33

Jin, R., Yu, S., Song, Z (...) Granger, DN., Li, G. (2010). Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke. Biochem Biophys Res Commun. 399(3):458-64

Pospisilik, JA., Schramek, D., Schnidar, H (...) Esterbauer, H., Penninger, JM. (2010). Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell. 140(1):148-60

Leibbrandt, A., Penninger, JM. (2010). Novel functions of RANK(L) signaling in the immune system. Adv Exp Med Biol. 658:77-94

Awad, AE., Kandalam, V., Chakrabarti, S (...) Oudit, GY., Kassiri, Z. (2010). Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. Am J Physiol Cell Physiol. 298(3):C679-92

Wysocki, J., Ye, M., Rodriguez, E (...) Penninger, JM., Batlle, D. (2010). Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 55(1):90-8

del Toro, R., Prahst, C., Mathivet, T (...) Penninger, J., Eichmann, A. (2010). Identification and functional analysis of endothelial tip cell-enriched genes. Blood. 116(19):4025-33

Paolino, M., Penninger, JM. (2010). Cbl-b in T-cell activation. Semin Immunopathol. 32(2):137-48

Hanada, R., Hanada, T., Penninger, JM. (2010). Physiology and pathophysiology of the RANKL/RANK system. Biol Chem. 391(12):1365-70

Charlier, E., Condé, C., Zhang, J (...) Piette, J., Gloire, G. (2010). SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity. Leukemia. 24(4):821-32

Meixner, A., Karreth, F., Kenner, L., Penninger, JM., Wagner, EF. (2010). Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death Differ. 17(9):1409-19

Neely, GG., Hess, A., Costigan, M (...) Woolf, CJ., Penninger, JM. (2010). A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell. 143(4):628-38

Zhong, J., Basu, R., Guo, D (...) Kassiri, Z., Oudit, GY. (2010). Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation. 122(7):717-28, 18 p following 728

Seo, J., Asaoka, Y., Nagai, Y (...) Katada, T., Nishina, H. (2010). Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J Cell Biochem. 110(4):1022-37

Oudit, GY., Liu, GC., Zhong, J (...) Kassiri, Z., Scholey, JW. (2010). Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes. 59(2):529-38

Guo, D., Kassiri, Z., Basu, R (...) Backx, PH., Oudit, GY. (2010). Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circ Res. 107(10):1275-89

Blaas, L., Kornfeld, JW., Schramek, D (...) Trauner, M., Casanova, E. (2010). Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology. 51(4):1319-26

Treml, B., Neu, N., Kleinsasser, A (...) Penninger, J., Loeckinger, A. (2010). Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets. Crit Care Med. 38(2):596-601

Haubner, BJ., Neely, GG., Voelkl, JG (...) Penninger, JM., Metzler, B. (2010). PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. PLoS One. 5(2):e9350

Schramek, D., Leibbrandt, A., Sigl, V (...) Schett, G., Penninger, JM. (2010). Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 468(7320):98-102

Molyneux, SD., Di Grappa, MA., Beristain, AG (...) Kirschner, LS., Khokha, R. (2010). Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. J Clin Invest. 120(9):3310-25

Kuba, K., Imai, Y., Ohto-Nakanishi, T., Penninger, JM. (2010). Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacol Ther. 128(1):119-28

Klaiber, M., Kruse, M., Völker, K (...) Pongs, O., Kuhn, M. (2010). Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol. 105(5):583-95

Imai, Y., Kuba, K., Ohto-Nakanishi, T., Penninger, JM. (2010). Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 74(3):405-10

Saade, M., Irla, M., Yammine, M (...) Chauvet, S., Nguyen, C. (2010). Spatial (Tbata) expression in mature medullary thymic epithelial cells. Eur J Immunol. 40(2):530-8

Leibbrandt, A., Penninger, JM. (2009). ESCI award lecture: from a little mouse to rationale medicine for bone loss. Eur J Clin Invest. 39(10):842-50

Osterreicher, CH., Taura, K., De Minicis, S (...) Penninger, JM., Brenner, DA. (2009). Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology. 50(3):929-38

Spurrell, DR., Luckashenak, NA., Minney, DC (...) Clements, JL., West, KA. (2009). Vav1 regulates the migration and adhesion of dendritic cells. J Immunol. 183(1):310-8

Nagatake, T., Fukuyama, S., Kim, DY (...) Kunisawa, J., Kiyono, H. (2009). Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. J Exp Med. 206(11):2351-64

Galluzzi, L., Aaronson, SA., Abrams, J (...) Zhivotovsky, B., Kroemer, G. (2009). Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ. 16(8):1093-107

Oudit, GY., Imai, Y., Kuba, K., Scholey, JW., Penninger, JM. (2009). The role of ACE2 in pulmonary diseases--relevance for the nephrologist. Nephrol Dial Transplant. 24(5):1362-5

Tanemura, S., Momose, H., Shimizu, N (...) Katada, T., Nishina, H. (2009). Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. J Biochem. 145(3):345-54

Loeser, S., Penninger, J.M. (2009). Regulation of T cell anergy and escape from regulatory T cells suppression by Cbl-b. In: The Epigenetics of Autoimmune disease. Ed. N. Zouali. :pp. 75-94

Cronin, SJ., Nehme, NT., Limmer, S (...) Ferrandon, D., Penninger, JM. (2009). Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Science. 325(5938):340-3

Singer, D., Camargo, SM., Huggel, K (...) Penninger, JM., Verrey, F. (2009). Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3. J Biol Chem. 284(30):19953-60

Hayer, S., Pundt, N., Peters, MA (...) Schett, G., Pap, T. (2009). PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis. FASEB J. 23(12):4288-98

Leibbrandt, A., Penninger, JM. (2009). RANK(L) as a key target for controlling bone loss. Adv Exp Med Biol. 647:130-45

Paolino, M., Penninger, JM. (2009). E3 ubiquitin ligases in T-cell tolerance. Eur J Immunol. 39(9):2337-44

Joza, N., Pospisilik, JA., Hangen, E (...) Penninger, JM., Kroemer, G. (2009). AIF: not just an apoptosis-inducing factor. Ann N Y Acad Sci. 1171:2-11

Köcher, T., Pichler, P., Schutzbier, M (...) Penninger, JM., Mechtler, K. (2009). High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: a new mass spectrometric method combining the benefits of all. J Proteome Res. 8(10):4743-52

Oudit, GY., Penninger, JM. (2009). Cardiac regulation by phosphoinositide 3-kinases and PTEN. Cardiovasc Res. 82(2):250-60

Fontán-Lozano, A., Romero-Granados, R., del-Pozo-Martín, Y (...) Penninger, JM., Carrión, AM. (2009). Lack of DREAM protein enhances learning and memory and slows brain aging. Curr Biol. 19(1):54-60

Kassiri, Z., Zhong, J., Guo, D (...) Penninger, JM., Oudit, GY. (2009). Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail. 2(5):446-55

Camargo, SM., Singer, D., Makrides, V (...) Penninger, JM., Verrey, F. (2009). Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations. Gastroenterology. 136(3):872-82

Mizoguchi, T., Muto, A., Udagawa, N (...) Ito, M., Takahashi, N. (2009). Identification of cell cycle-arrested quiescent osteoclast precursors in vivo. J Cell Biol. 184(4):541-54

Oudit, GY., Kassiri, Z., Jiang, C (...) Penninger, JM., Butany, J. (2009). SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. Eur J Clin Invest. 39(7):618-25

Blyszczuk, P., Kania, G., Dieterle, T (...) Lüscher, TF., Eriksson, U. (2009). Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. Circ Res. 105(9):912-20

Hanada, R., Leibbrandt, A., Hanada, T (...) Narumiya, S., Penninger, JM. (2009). Central control of fever and female body temperature by RANKL/RANK. Nature. 462(7272):505-9

Leibbrandt, A., Penninger, JM. (2009). RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies. Adv Exp Med Biol. 649:100-13

Gruber, T., Hermann-Kleiter, N., Hinterleitner, R (...) Penninger, JM., Baier, G. (2009). PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Sci Signal. 2(76):ra30

Ban, K., Cooper, AJ., Samuel, S (...) Oudit, GY., Tsushima, RG. (2008). Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circ Res. 103(6):643-53

Hara, H., Ishihara, C., Takeuchi, A (...) Yoshida, H., Saito, T. (2008). Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9. J Immunol. 181(2):918-30

Imai, Y., Kuba, K., Penninger, JM. (2008). [Lessons from SARS: a new potential therapy for acute respiratory distress syndrome (ARDS) with angiotensin converting enzyme 2 (ACE2)]. Masui. 57(3):302-10

Oudit, GY., Kassiri, Z., Zhou, J (...) Scholey, JW., Penninger, JM. (2008). Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovasc Res. 78(3):505-14

Imai, Y., Kuba, K., Neely, GG (...) Binder, CJ., Penninger, JM. (2008). Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 133(2):235-49

Leibbrandt, A., Penninger, JM. (2008). RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci. 1143:123-50

Hikosaka, Y., Nitta, T., Ohigashi, I (...) Akiyama, T., Takahama, Y. (2008). The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator. Immunity. 29(3):438-50

Penninger, J., Imai, Y., Kuba, K. (2008). The discovery of ACE2 and its role in acute lung injury. Exp Physiol.

Meixner, A., Zenz, R., Schonthaler, HB (...) Penninger, JM., Wagner, EF. (2008). Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation. Nat Cell Biol. 10(8):1003-11

Imai, Y., Kuba, K., Penninger, JM. (2008). The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Exp Physiol. 93(5):543-8

Garabelli, PJ., Modrall, JG., Penninger, JM., Ferrario, CM., Chappell, MC. (2008). Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Exp Physiol. 93(5):613-21

Chavakis, E., Carmona, G., Urbich, C (...) Chavakis, T., Dimmeler, S. (2008). Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells. Circ Res. 102(8):942-9

Joza, N., Galindo, K., Pospisilik, JA (...) Kroemer, G., Penninger, JM. (2008). The molecular archaeology of a mitochondrial death effector: AIF in Drosophila. Cell Death Differ. 15(6):1009-18

Qiao, G., Li, Z., Molinero, L (...) Penninger, JM., Zhang, J. (2008). T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Mol Cell Biol. 28(7):2470-80

Kuwana, H., Terada, Y., Kobayashi, T (...) Sasaki, T., Sasaki, S. (2008). The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney Int. 73(4):430-45

Wada, T., Stepniak, E., Hui, L (...) Wagner, EF., Penninger, JM. (2008). Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ. 15(1):89-93

Raberger, J., Boucheron, N., Sakaguchi, S., Penninger, JM., Ellmeier, W. (2008). Impaired T-cell development in the absence of Vav1 and Itk. Eur J Immunol. 38(12):3530-42

Lovren, F., Pan, Y., Quan, A (...) Penninger, JM., Verma, S. (2008). Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. Am J Physiol Heart Circ Physiol. 295(4):H1377-84

Akiyama, T., Shimo, Y., Yanai, H (...) Takahama, Y., Inoue, J. (2008). The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 29(3):423-37

Reich, HN., Oudit, GY., Penninger, JM., Scholey, JW., Herzenberg, AM. (2008). Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int. 74(12):1610-6

Haubner, B. J., Neely, G., Pachinger, O., Penninger, J. M., Metzler, B. (2008). PI3Kgamma AKTing during myocardial ischemia and reperfusion. Wiener Klin. Wochenschrift. (15):95-97

Leibbrandt, A., Penninger, J. M. (2008). RANK(L) as a key target for controlling bone loss. In: Therapeutic Targets of the TNF Superfamily. Ed. I. Grewal. Landes Bioscience/Eurekah.com.

Loeser, S., Penninger, J.M. (2008). The Role of the E3 ubiquitin ligase Cbl-b in T-cells signalling and tolerance. In: CBL Proteins. Ed. A. Tsygankov. Nova Science Publishers Inc. :Chapter 9

Leibbrandt, A., Penninger, J. M. (2008). The role of RANKL in cancer. In: Encyclopedia of Cancer. Ed. Schwab, M. Springer.

Penninger, J.M. (2008). Do genes dream? In: Identitaet(en). Ed. GLOBArt. Springer.

Galluzzi, L., Joza, N., Tasdemir, E (...) Madeo, F., Kroemer, G. (2008). No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15(7):1113-23

Feraud, O., Debili, N., Penninger, JM., Kroemer, G. (2007). Cavitation of embryoid bodies requires optimal oxidative phosphorylation and AIF. Cell Death Differ. 14(2):385-7

Cronin, SJ., Penninger, JM. (2007). From T-cell activation signals to signaling control of anti-cancer immunity. Immunol Rev. 220:151-68

Pospisilik, JA., Knauf, C., Joza, N (...) Burcelin, R., Penninger, JM. (2007). Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell. 131(3):476-91

Tassi, I., Cella, M., Gilfillan, S (...) Penninger, JM., Colonna, M. (2007). p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity. 27(2):214-27

Kuba, K., Zhang, L., Imai, Y (...) Liu, PP., Penninger, JM. (2007). Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res. 101(4):e32-42

Wong, DW., Oudit, GY., Reich, H (...) Herzenberg, AM., Scholey, JW. (2007). Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. Am J Pathol. 171(2):438-51

Imai, Y., Kuba, K., Penninger, JM. (2007). Angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Cell Mol Life Sci. 64(15):2006-12

Liu, L., Puri, KD., Penninger, JM., Kubes, P. (2007). Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood. 110(4):1191-8

Zuber, AM., Singer, D., Penninger, JM., Rossier, BC., Firsov, D. (2007). Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice. J Am Soc Nephrol. 18(6):1672-8

Loeser, S., Penninger, JM. (2007). Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b. Semin Immunol. 19(3):206-14

Shambharkar, PB., Blonska, M., Pappu, BP (...) Penninger, J., Lin, X. (2007). Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J. 26(7):1794-805

Séverin, S., Gratacap, MP., Lenain, N (...) Plantavid, M., Payrastre, B. (2007). Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth. J Clin Invest. 117(4):944-52

Nishio, M., Watanabe, K., Sasaki, J (...) Suzuki, A., Sasaki, T. (2007). Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol. 9(1):36-44

Fischer, L., Gukovskaya, AS., Penninger, JM (...) Gukovsky, I., Pandol, SJ. (2007). Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca(2+) responses in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol. 292(3):G875-86

Zhang, L., Anglesio, MS., O'Sullivan, M (...) Sorensen, PH., Penninger, JM. (2007). The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nat Med. 13(9):1060-9

Hara, H., Ishihara, C., Takeuchi, A (...) Penninger, JM., Saito, T. (2007). The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol. 8(6):619-29

Alnaeeli, M., Park, J., Mahamed, D., Penninger, JM., Teng, YT. (2007). Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss. J Bone Miner Res. 22(6):775-80

Loeser, S., Penninger, JM. (2007). The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity. Cell Cycle. 6(20):2478-85

Loeser, S., Loser, K., Bijker, MS (...) Melief, CJ., Penninger, JM. (2007). Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. J Exp Med. 204(4):879-91

Rossi, SW., Kim, MY., Leibbrandt, A (...) Lane, PJ., Anderson, G. (2007). RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med. 204(6):1267-72

Oudit, GY., Kassiri, Z., Patel, MP (...) Khokha, R., Penninger, JM. (2007). Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res. 75(1):29-39

Nakamichi, Y., Udagawa, N., Kobayashi, Y (...) Penninger, JM., Takahashi, N. (2007). Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. J Immunol. 178(1):192-200

Danilczyk, U., Sarao, R., Remy, C (...) Wagner, CA., Penninger, JM. (2006). Essential role for collectrin in renal amino acid transport. Nature. 444(7122):1088-91

Rangachari, M., Mauermann, N., Marty, RR (...) Penninger, JM., Eriksson, U. (2006). T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med. 203(8):2009-19

Wada, T., Nakashima, T., Hiroshi, N., Penninger, JM. (2006). RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med. 12(1):17-25

Marty, RR., Dirnhofer, S., Mauermann, N (...) Penninger, JM., Eriksson, U. (2006). MyD88 signaling controls autoimmune myocarditis induction. Circulation. 113(2):258-65

Cheng, HY., Dziema, H., Papp, J (...) Penninger, JM., Obrietan, K. (2006). The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. J Neurosci. 26(50):12984-95

Oudit, GY., Herzenberg, AM., Kassiri, Z (...) Penninger, JM., Scholey, JW. (2006). Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. Am J Pathol. 168(6):1808-20

Vorbach, C., Capecchi, MR., Penninger, JM. (2006). Evolution of the mammary gland from the innate immune system? Bioessays. 28(6):606-16

Danilczyk, U., Penninger, JM. (2006). Angiotensin-converting enzyme II in the heart and the kidney. Circ Res. 98(4):463-71

Cheng, H-Y.M, Penninger, JM. (2006). Dream/KchIP/ Calsenilin: a multifunctional player in health and disease. In Neuronal Calcium Sensor Proteins (Philippov, Koch, eds.); Nova Science Publishers. :245-270

Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 (ACE2)-mediated regulation of cardiovascular peptides and its application for treating disease. Experimental Medicine. 24:71-77

Atfield, AD., Liu, P., Penninger JM. (2006). The biochemical mechanisms of T-cell anergy Curr. Immunol. Rev.. 2:73-99

Imai, Y., Kuba, K., Penninger, JM., (2006). The renin angiotensin system in acute respiratory distress syndrome. Drug Discovery Today. 3:225-229

Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 (ACE2)-mutant mice. Respiratory Molecular Medicine. 10:38-42

Nakashima T., Penninger, JM. (2006). Chemotactic regulation of cancer cell migration and bone metastases by RANKL. Experimental Medicine. 24:1777-80

Roy, AA., Nunn, C., Ming, H (...) Dixon, SJ., Chidiac, P. (2006). Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts. J Biol Chem. 281(43):32684-93

Loser, K., Mehling, A., Loeser, S (...) Penninger, JM., Beissert, S. (2006). Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med. 12(12):1372-9

Maruyama, K., Takada, Y., Ray, N (...) Yasuda, H., Matsuo, K. (2006). Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice. J Immunol. 177(6):3799-805

Cheung, EC., Joza, N., Steenaart, NA (...) Penninger, JM., Slack, RS. (2006). Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. EMBO J. 25(17):4061-73

Brown, D., Yu, BD., Joza, N (...) Penninger, JM., Martin, GR. (2006). Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proc Natl Acad Sci U S A. 103(26):9918-23

Sun, H., Kerfant, BG., Zhao, D (...) Penninger, JM., Backx, PH. (2006). Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. Circ Res. 98(11):1390-7

Yamamoto, Y., Udagawa, N., Matsuura, S (...) Noguchi, T., Takahashi, N. (2006). Osteoblasts provide a suitable microenvironment for the action of receptor activator of nuclear factor-kappaB ligand. Endocrinology. 147(7):3366-74

Kuba, K., Imai, Y., Penninger, JM. (2006). Angiotensin-converting enzyme 2 in lung diseases. Curr Opin Pharmacol. 6(3):271-6

Valdés, G., Neves, LA., Anton, L (...) Penninger, J., Brosnihan, KB. (2006). Distribution of angiotensin-(1-7) and ACE2 in human placentas of normal and pathological pregnancies. Placenta. 27(2-3):200-7

Alnaeeli, M., Penninger, JM., Teng, YT. (2006). Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. J Immunol. 177(5):3314-26

Zhao, M., Song, B., Pu, J (...) McCaig, CD., Penninger, JM. (2006). Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 442(7101):457-60

Kim, NS., Kim, HJ., Koo, BK (...) Penninger, JM., Kong, YY. (2006). Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Mol Cell Biol. 26(3):1002-13

Kuba, K., Imai, Y., Rao, S., Jiang, C., Penninger, JM. (2006). Lessons from SARS: control of acute lung failure by the SARS receptor ACE2. J Mol Med (Berl). 84(10):814-20

Jones, DH., Nakashima, T., Sanchez, OH (...) Wada, T., Penninger, JM. (2006). Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 440(7084):692-6

Eriksson, U., Kopf, M., Afanasyeva, M., Penninger, JM. (2005). Models of autoimmune heart disease: a review of current status. Drug Discovery Today: Disease Models, online edition.

Eriksson, U., Penninger, JM., Kopf, M. (2005). Autoimmune heart disease: from bench to bedside. Drug Discovery Today: Disease Mechanisms, online edition.

Kuba, K., Imai, Y., Penninger, JM. (2005). Angiotensin converting enzyme 2 (ACE2) and SARS infections. Experimental Medicine. 23:2830-5

Rangachari, M., Eriksson, U., Vollmann, EH., Penninger, JM. (2005). A novel model for pathogenesis of autoimmune heart failure: the role of dendritic cells. International Congress Series (Uehara Foundation Review). 1285:192-201

Liu, YC., Penninger, J., Karin, M. (2005). Immunity by ubiquitylation: a reversible process of modification. Nat Rev Immunol. 5(12):941-52

Imai, Y., Kuba, K., Rao, S (...) Jiang, C., Penninger, JM. (2005). Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 436(7047):112-6

Mahamed, DA., Marleau, A., Alnaeeli, M (...) Penninger, JM., Teng, YT. (2005). G(-) anaerobes-reactive CD4+ T-cells trigger RANKL-mediated enhanced alveolar bone loss in diabetic NOD mice. Diabetes. 54(5):1477-86

Wilson, LD., Ross, SA., Lepore, DA (...) Penninger, JM., Thomas, PQ. (2005). Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary. Gene Expr Patterns. 5(3):305-11

Kuba, K., Imai, Y., Rao, S (...) Jiang, C., Penninger, JM. (2005). A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. 11(8):875-9

Kolas, NK., Marcon, E., Crackower, MA (...) Spyropoulos, B., Moens, PB. (2005). Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility. Chromosoma. 114(2):92-102

Kerfant, BG., Gidrewicz, D., Sun, H (...) Penninger, JM., Backx, PH. (2005). Cardiac sarcoplasmic reticulum calcium release and load are enhanced by subcellular cAMP elevations in PI3Kgamma-deficient mice. Circ Res. 96(10):1079-86

Sasaki, J., Sasaki, T., Yamazaki, M (...) Suzuki, A., Kanaho, Y. (2005). Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med. 201(6):859-70

Ricci, R., Eriksson, U., Oudit, GY (...) Penninger, JM., Wagner, EF. (2005). Distinct functions of junD in cardiac hypertrophy and heart failure. Genes Dev. 19(2):208-13

Eriksson, U., Penninger, JM. (2005). Autoimmune heart failure: new understandings of pathogenesis. Int J Biochem Cell Biol. 37(1):27-32

Wang, X., Zeng, W., Soyombo, AA (...) Greengard, P., Muallem, S. (2005). Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nat Cell Biol. 7(4):405-11

Puri, KD., Doggett, TA., Huang, CY (...) Penninger, J., Diacovo, TG. (2005). The role of endothelial PI3Kgamma activity in neutrophil trafficking. Blood. 106(1):150-7

Wada, T., Nakashima, T., Oliveira-dos-Santos, AJ (...) Schett, G., Penninger, JM. (2005). The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med. 11(4):394-9

Krawczyk, CM., Jones, RG., Atfield, A (...) Ohashi, PS., Penninger, JM. (2005). Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b. J Immunol. 174(3):1472-8

Bachmaier, K., Penninger, JM. (2005). Chlamydia and antigenic mimicry. Curr Top Microbiol Immunol. 296:153-63

Joza, N., Oudit, GY., Brown, D (...) Rustin, P., Penninger, JM. (2005). Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Mol Cell Biol. 25(23):10261-72

Wada, T., Nishina, H., Katada, T., Penninger, JM. (2004). MKK7 couples stress signalling to G2/M cell cycle progression and cellular senescence. Exper. Med.. 22:1398-400

Wada, T., Joza, N., Cheng, HY (...) Nishina, H., Penninger, JM. (2004). MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol. 6(3):215-26

Vahsen, N., Candé, C., Brière, JJ (...) Rustin, P., Kroemer, G. (2004). AIF deficiency compromises oxidative phosphorylation. EMBO J. 23(23):4679-89

Danilczyk, U., Penninger, J. (2004). Hypertension with a grain of salt. Nat Med. 10(11):1163-4

Matsumoto, G., Kubota, E., Omi, Y., Lee, U., Penninger, JM. (2004). Essential role of LFA-1 in activating Th2-like responses by alpha-galactosylceramide-activated NKT cells. J Immunol. 173(8):4976-84

Gronski, MA., Boulter, JM., Moskophidis, D (...) Gascoigne, NR., Ohashi, PS. (2004). TCR affinity and negative regulation limit autoimmunity. Nat Med. 10(11):1234-9

Jeon, MS., Atfield, A., Venuprasad, K (...) Liu, YC., Penninger, JM. (2004). Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity. 21(2):167-77

Reif, K., Okkenhaug, K., Sasaki, T (...) Vanhaesebroeck, B., Cyster, JG. (2004). Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing. J Immunol. 173(4):2236-40

Anglesio, MS., Evdokimova, V., Melnyk, N (...) Penninger, J., Sorensen, PH. (2004). Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. Hum Mol Genet. 13(18):2061-74

Cheng, HY., Laviolette, SR., van der Kooy, D., Penninger, JM. (2004). DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine. Eur J Neurosci. 19(11):3033-41

Wada, T., Penninger, JM. (2004). Stress kinase MKK7: savior of cell cycle arrest and cellular senescence. Cell Cycle. 3(5):577-9

Wada, T., Penninger, JM. (2004). Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 23(16):2838-49

Perfettini, JL., Roumier, T., Castedo, M (...) Piacentini, M., Kroemer, G. (2004). NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope. J Exp Med. 199(5):629-40

Candé, C., Vahsen, N., Kouranti, I (...) Penninger, JM., Kroemer, G. (2004). AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis. Oncogene. 23(8):1514-21

Marra, LE., Zhang, ZX., Joe, B (...) Penninger, J., Zhang, L. (2004). IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. J Immunol. 172(2):1028-35

Hara, H., Bakal, C., Wada, T (...) Saito, T., Penninger, JM. (2004). The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. J Exp Med. 200(9):1167-77

Cheng, HY., Penninger, JM. (2004). DREAMing about arthritic pain. Ann Rheum Dis. 63 Suppl 2:ii72-ii75

Oudit, GY., Sun, H., Kerfant, BG (...) Penninger, JM., Backx, PH. (2004). The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol. 37(2):449-71

Rangachari, M., Penninger, JM. (2004). Negative regulation of T cell receptor signals. Curr Opin Pharmacol. 4(4):415-22

Gukovsky, I., Cheng, JH., Nam, KJ (...) Pandol, SJ., Gukovskaya, AS. (2004). Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells. Gastroenterology. 126(2):554-66

Martin-McCaffrey, L., Willard, FS., Oliveira-dos-Santos, AJ (...) Siderovski, DP., D'Souza, SJ. (2004). RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Dev Cell. 7(5):763-9

Danilczyk, U., Eriksson, U., Oudit, GY., Penninger, JM. (2004). Physiological roles of angiotensin-converting enzyme 2. Cell Mol Life Sci. 61(21):2714-9

Cheng, HY., Obrietan, K., Cain, SW (...) Ralph, MR., Penninger, JM. (2004). Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron. 43(5):715-28

Wang, X., Huang, G., Luo, X., Penninger, JM., Muallem, S. (2004). Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells. J Biol Chem. 279(40):41642-9

Fischer, L., Gukovskaya, AS., Young, SH (...) Friess, H., Pandol, SJ. (2004). Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase. Am J Physiol Gastrointest Liver Physiol. 287(6):G1200-12

Nishitai, G., Shimizu, N., Negishi, T (...) Nishina, H., Katada, T. (2004). Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells. J Biol Chem. 279(3):1621-6

Oudit, GY., Crackower, MA., Eriksson, U (...) Backx, PH., Penninger, JM. (2003). Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 108(17):2147-52

Griffiths, EK., Sanchez, O., Mill, P (...) Hui, CC., Penninger, JM. (2003). Cbl-3-deficient mice exhibit normal epithelial development. Mol Cell Biol. 23(21):7708-18

Jun, JE., Wilson, LE., Vinuesa, CG (...) Nelms, KA., Goodnow, CC. (2003). Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity. 18(6):751-62

Suzuki, N., Chen, NJ., Millar, DG (...) Ohashi, PS., Yeh, WC. (2003). IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. J Immunol. 170(8):4031-5

Oudit, GY., Crackower, MA., Backx, PH., Penninger, JM. (2003). The role of ACE2 in cardiovascular physiology. Trends Cardiovasc Med. 13(3):93-101

Eriksson, U., Kurrer, MO., Sonderegger, I (...) Penninger, JM., Kopf, M. (2003). Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. J Exp Med. 197(3):323-31

Penninger, JM., Kroemer, G. (2003). Mitochondria, AIF and caspases--rivaling for cell death execution. Nat Cell Biol. 5(2):97-9

Schmitt, E., Parcellier, A., Gurbuxani, S (...) Kroemer, G., Garrido, C. (2003). Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res. 63(23):8233-40

Suzuki, N., Suzuki, S., Eriksson, U (...) Saito, T., Yeh, WC. (2003). IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. J Immunol. 171(11):6065-71

Eriksson, U., Ricci, R., Hunziker, L (...) Kopf, M., Penninger, JM. (2003). Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med. 9(12):1484-90

Brosnihan, KB., Neves, LA., Joyner, J (...) Penninger, J., Ferrario, CM. (2003). Enhanced renal immunocytochemical expression of ANG-(1-7) and ACE2 during pregnancy. Hypertension. 42(4):749-53

Crackower, MA., Kolas, NK., Noguchi, J (...) Moens, PB., Penninger, JM. (2003). Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis. Science. 300(5623):1291-5

Danilczyk, U., Eriksson, U., Crackower, MA., Penninger, JM. (2003). A story of two ACEs. J Mol Med (Berl). 81(4):227-34

Heximer, SP., Knutsen, RH., Sun, X (...) Mecham, RP., Blumer, KJ. (2003). Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. J Clin Invest. 111(8):1259

Cheng, HY., Penninger, JM. (2003). When the DREAM is gone: from basic science to future prospectives in pain management and beyond. Expert Opin Ther Targets. 7(2):249-63

Kishimoto, H., Nakagawa, K., Watanabe, T (...) Nishina, H., Katada, T. (2003). Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem. 278(19):16595-601

Kim, C., Marchal, CC., Penninger, J., Dinauer, MC. (2003). The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions. J Immunol. 171(8):4425-30

Giuriato, S., Pesesse, X., Bodin, S (...) Erneux, C., Payrastre, B. (2003). SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels. Biochem J. 376(Pt 1):199-207

Gonzalez-Espinosa, C., Odom, S., Olivera, A (...) Penninger, JM., Rivera, J. (2003). Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. J Exp Med. 197(11):1453-65

Nakashima, T., Wada, T., Penninger, JM. (2003). RANKL and RANK as novel therapeutic targets for arthritis. Curr Opin Rheumatol. 15(3):280-7

Saibil, SD., Ohteki, T., White, FM (...) Hunt, DF., Ohashi, PS. (2003). Weak agonist self-peptides promote selection and tuning of virus-specific T cells. Eur J Immunol. 33(3):685-96

Hara, H., Wada, T., Bakal, C (...) Rottapel, R., Penninger, JM. (2003). The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 18(6):763-75

Irie-Sasaki, J., Sasaki, T., Penninger, JM. (2003). CD45 regulated signaling pathways. Curr Top Med Chem. 3(7):783-96

Cheng, H.-YM., Penninger, JM. (2002). Transcriptional mechanisms underlying neuropathic pain: DREAM, transcription factors and future pain management? Exp. Rev. Neurotherapeutics. 2:677-89

Sasaki, T., Sasaki-Irie, J., Penninger, JM. (2002). The potential role of CD45 as a drug target. Curr. Topics Med. Chem.. 131:495-501

Penninger, JM., Bachmaier, K. (2002). Infections and the immune response to cardiac antigens. Book chapter. Epitope recognition since Landsteiner's discovery - 100 years since the discovery of human blood groups (Eibl, M., Mayr, WR., Thorbecke, GJ., eds.). :103-17

Crackower, MA., Oudit, GY., Kozieradzki, I (...) Backx, PH., Penninger, JM. (2002). Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 110(6):737-49

Matsumoto, G., Tsunematsu, S., Tsukinoki, K (...) Shindo, J., Penninger, JM. (2002). Essential role of the adhesion receptor LFA-1 for T cell-dependent fulminant hepatitis. J Immunol. 169(12):7087-96

Roumier, T., Vieira, HL., Castedo, M (...) Roques, B., Kroemer, G. (2002). The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway. Cell Death Differ. 9(11):1212-9

Jones, DH., Kong, YY., Penninger, JM. (2002). Role of RANKL and RANK in bone loss and arthritis. Ann Rheum Dis. 61 Suppl 2:ii32-9

Griffiths, EK., Penninger, JM. (2002). Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Curr Opin Immunol. 14(3):317-22

Suzuki, N., Suzuki, S., Duncan, GS (...) Mak, TW., Yeh, WC. (2002). Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 416(6882):750-6

Theill, LE., Boyle, WJ., Penninger, JM. (2002). RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol. 20:795-823

Kim, HJ., Yoon, MJ., Lee, J., Penninger, JM., Kong, YY. (2002). Osteoprotegerin ligand induces beta-casein gene expression through the transcription factor CCAAT/enhancer-binding protein beta. J Biol Chem. 277(7):5339-44

Opavsky, MA., Martino, T., Rabinovitch, M (...) Chan, J., Liu, PP. (2002). Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis. J Clin Invest. 109(12):1561-9

Eriksson, U., Danilczyk, U., Penninger, JM. (2002). Just the beginning: novel functions for angiotensin-converting enzymes. Curr Biol. 12(21):R745-52

Maté, MJ., Ortiz-Lombardía, M., Boitel, B (...) Kroemer, G., Alzari, PM. (2002). The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol. 9(6):442-6

Sasaki, T., Suzuki, A., Sasaki, J., Penninger, JM. (2002). Phosphoinositide 3-kinases in immunity: lessons from knockout mice. J Biochem. 131(4):495-501

Krawczyk, C., Oliveira-dos-Santos, A., Sasaki, T (...) Alt, F., Penninger, JM. (2002). Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 16(3):331-43

Joza, N., Kroemer, G., Penninger, JM. (2002). Genetic analysis of the mammalian cell death machinery. Trends Genet. 18(3):142-9

Cheng, HY., Pitcher, GM., Laviolette, SR (...) Salter, MW., Penninger, JM. (2002). DREAM is a critical transcriptional repressor for pain modulation. Cell. 108(1):31-43

Watanabe, T., Nakagawa, K., Ohata, S (...) Nishina, H., Katada, T. (2002). SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis. Dev Biol. 250(2):332-47

Ito, N., Yokomizo, T., Sasaki, T (...) Hanaoka, K., Shimizu, T. (2002). Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. J Biol Chem. 277(47):44898-904

Crackower, MA., Sarao, R., Oudit, GY (...) Yagil, Y., Penninger, JM. (2002). Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 417(6891):822-8

Griffiths, EK., Penninger, JM. (2002). ADAP-ting TCR signaling to integrins. Sci STKE. 2002(127):re3

Kurrer, MO., Kopf, M., Penninger, J., Eriksson, U. (2002). Cytokines that regulate autoimmune myocarditis. Swiss Med Wkly. 132(29-30):408-13

Tani-Ishii, N., Penninger, JM., Matsumoto, G., Teranaka, T., Umemoto, T. (2002). The role of LFA-1 in osteoclast development induced by co-cultures of mouse bone marrow cells and MC3T3-G2/PA6 cells. J Periodontal Res. 37(3):184-91

Joza, N., Susin, SA., Daugas, E (...) Kroemer, G., Penninger, JM. (2001). Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 410(6828):549-54

Bony, C., Roche, S., Shuichi, U (...) Mano, H., Pucéat, M. (2001). A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. J Cell Biol. 152(4):717-28

Irie-Sasaki, J., Sasaki, T., Matsumoto, W (...) Rothstein, DM., Penninger, JM. (2001). CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 409(6818):349-54

Loeffler, M., Daugas, E., Susin, SA (...) Penninger, JM., Kroemer, G. (2001). Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. FASEB J. 15(3):758-67

Mak, TW., Penninger, JM., Ohashi, PS. (2001). Knockout mice: a paradigm shift in modern immunology. Nat Rev Immunol. 1(1):11-9

Osawa, M., Tong, KI., Lilliehook, C (...) Ikura, M., Ames, JB. (2001). Calcium-regulated DNA binding and oligomerization of the neuronal calcium-sensing protein, calsenilin/DREAM/KChIP3. J Biol Chem. 276(44):41005-13

Wada, T., Nakagawa, K., Watanabe, T (...) Nishina, H., Katada, T. (2001). Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation. J Biol Chem. 276(33):30892-7

Miramar, MD., Costantini, P., Ravagnan, L (...) Kroemer, G., Susin, SA. (2001). NADH oxidase activity of mitochondrial apoptosis-inducing factor. J Biol Chem. 276(19):16391-8

Griffiths, EK., Krawczyk, C., Kong, YY (...) Rudd, CE., Penninger, JM. (2001). Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science. 293(5538):2260-3

Diao, J., Khine, AA., Sarangi, F (...) Penninger, J., Richardson, CD. (2001). X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway. J Biol Chem. 276(11):8328-40

Krawczyk, C., Penninger, JM. (2001). Molecular motors involved in T cell receptor clusterings. J Leukoc Biol. 69(3):317-30

Penninger, JM., Irie-Sasaki, J., Sasaki, T., Oliveira-dos-Santos, AJ. (2001). CD45: new jobs for an old acquaintance. Nat Immunol. 2(5):389-96

Sasaki, T., Sasaki-Irie, J., Penninger, JM. (2001). New insights into the transmembrane protein tyrosine phosphatase CD45. Int J Biochem Cell Biol. 33(11):1041-6

Sasaki, T., Sasaki, J., Suzuki, A., Penninger, JM. (2001). [Involvement of phosphoinositide 3-kinases and phosphoinositide phosphatases in immune responses, glucose metabolism and tumorigenesis]. Tanpakushitsu Kakusan Koso. 46(12):1820-9

Penninger, JM., Woodgett, J. (2001). Stem cells. PTEN--coupling tumor suppression to stem cells? Science. 294(5549):2116-8

Ravagnan, L., Gurbuxani, S., Susin, SA (...) Garrido, C., Kroemer, G. (2001). Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol. 3(9):839-43

Krawczyk, C., Penninger, JM. (2001). Molecular controls of antigen receptor clustering and autoimmunity. Trends Cell Biol. 11(5):212-20

Tafuri, A., Shahinian, A., Bladt, F (...) Ohashi, PS., Mak, TW. (2001). ICOS is essential for effective T-helper-cell responses. Nature. 409(6816):105-9

Yum, HK., Arcaroli, J., Kupfner, J (...) Park, JS., Abraham, E. (2001). Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. J Immunol. 167(11):6601-8

Sasaki, T., Wada, T., Kishimoto, H (...) Nishina, H., Penninger, JM. (2001). The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. J Exp Med. 194(6):757-68

Sohal, DS., Nghiem, M., Crackower, MA (...) Penninger, JM., Molkentin, JD. (2001). Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circ Res. 89(1):20-5

Suzuki, A., Yamaguchi, MT., Ohteki, T (...) Nakano, T., Mak, TW. (2001). T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 14(5):523-34

Kong, YY., Boyle, WJ., Penninger, JM. (2000). Osteoprotegerin ligand: a regulator of immune responses and bone physiology. Immunol Today. 21(10):495-502

Bachmaier, K., Le, J., Penninger, JM. (2000). "Catching heart disease": antigenic mimicry and bacterial infections. Nat Med. 6(8):841-2

Susin, SA., Daugas, E., Ravagnan, L (...) Earnshaw, WC., Kroemer, G. (2000). Two distinct pathways leading to nuclear apoptosis. J Exp Med. 192(4):571-80

Bachmaier, K., Krawczyk, C., Kozieradzki, I (...) Lipkowitz, S., Penninger, JM. (2000). Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 403(6766):211-6

Daugas, E., Susin, SA., Zamzami, N (...) Penninger, J., Kroemer, G. (2000). Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J. 14(5):729-39

Penninger, JM., Bachmaier, K. (2000). Review of microbial infections and the immune response to cardiac antigens. J Infect Dis. 181 Suppl 3:S498-504

Fata, JE., Kong, YY., Li, J (...) Khokha, R., Penninger, JM. (2000). The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 103(1):41-50

Ferri, KF., Jacotot, E., Blanco, J (...) Penninger, JM., Kroemer, G. (2000). Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases. J Exp Med. 192(8):1081-92

Oliveira-Dos-Santos, AJ., Matsumoto, G., Snow, BE (...) Siderovski, DP., Penninger, JM. (2000). Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci U S A. 97(22):12272-7

Teng, YT., Nguyen, H., Gao, X (...) Ellen, RP., Penninger, JM. (2000). Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. J Clin Invest. 106(6):R59-67

Sasaki, T., Irie-Sasaki, J., Jones, RG (...) Suzuki, A., Penninger, JM. (2000). Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science. 287(5455):1040-6

Sasaki, T., Irie-Sasaki, J., Horie, Y (...) Tsao, M., Penninger, JM. (2000). Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Nature. 406(6798):897-902

Krawczyk, C., Bachmaier, K., Sasaki, T (...) Alt, FW., Penninger, JM. (2000). Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 13(4):463-73

Matsumoto, G., Omi, Y., Lee, U (...) Shindo, J., Penninger, JM. (2000). Adhesion mediated by LFA-1 is required for efficient IL-12-induced NK and NKT cell cytotoxicity. Eur J Immunol. 30(12):3723-31

Kong, YY., Penninger, JM. (2000). Molecular control of bone remodeling and osteoporosis. Exp Gerontol. 35(8):947-56

Liu, P., Aitken, K., Kong, YY (...) Mak, TW., Penninger, JM. (2000). The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nat Med. 6(4):429-34

Zhang, J., Shehabeldin, A., da Cruz, LA (...) Penninger, JM., Siminovitch, KA. (1999). Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med. 190(9):1329-42

Opavsky, MA., Penninger, J., Aitken, K (...) Mak, T., Liu, P. (1999). Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection. Circ Res. 85(6):551-8

Penninger, JM., Fischer, KD., Sasaki, T (...) Ohashi, PS., Bachmann, MF. (1999). The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation. Eur J Immunol. 29(5):1709-18

Hakem, A., Sasaki, T., Kozieradzki, I., Penninger, JM. (1999). The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. J Exp Med. 189(6):957-68

Susin, SA., Lorenzo, HK., Zamzami, N (...) Penninger, JM., Kroemer, G. (1999). Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 397(6718):441-6

Penninger, JM., Crabtree, GR. (1999). The actin cytoskeleton and lymphocyte activation. Cell. 96(1):9-12

Kong, YY., Boyle, WJ., Penninger, JM. (1999). Osteoprotegerin ligand: a common link between osteoclastogenesis, lymph node formation and lymphocyte development. Immunol Cell Biol. 77(2):188-93

Khan, Q., Penninger, JM., Yang, L (...) Kozieradzki, I., Zhang, L. (1999). Regulation of apoptosis in mature alphabeta+CD4-CD8- antigen-specific suppressor T cell clones. J Immunol. 162(10):5860-7

Kong, YY., Yoshida, H., Sarosi, I (...) Boyle, WJ., Penninger, JM. (1999). OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 397(6717):315-23

Oliveira-dos-Santos, AJ., Ho, A., Tada, Y (...) Mak, TW., Penninger, JM. (1999). CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis. J Immunol. 162(8):4490-5

Liu, Q., Sasaki, T., Kozieradzki, I (...) Dumont, DJ., Penninger, JM. (1999). SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev. 13(7):786-91

Kong, YY., Feige, U., Sarosi, I (...) Boyle, WJ., Penninger, JM. (1999). Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 402(6759):304-9

Bachmann, MF., Nitschke, L., Krawczyk, C (...) Fischer, KD., Penninger, JM. (1999). The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens. J Immunol. 163(1):137-42

Lorenzo, HK., Susin, SA., Penninger, J., Kroemer, G. (1999). Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death Differ. 6(6):516-24

Irwin, MW., Mak, S., Mann, DL (...) Shou, Z., Liu, P. (1999). Tissue expression and immunolocalization of tumor necrosis factor-alpha in postinfarction dysfunctional myocardium. Circulation. 99(11):1492-8

Keane, MM., Ettenberg, SA., Nau, MM (...) Penninger, J., Lipkowitz, S. (1999). cbl-3: a new mammalian cbl family protein. Oncogene. 18(22):3365-75

Lomaga, MA., Yeh, WC., Sarosi, I (...) Goeddel, DV., Mak, TW. (1999). TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev. 13(8):1015-24

Bachmaier, K., Neu, N., de la Maza, LM (...) Hessel, A., Penninger, JM. (1999). Chlamydia infections and heart disease linked through antigenic mimicry. Science. 283(5406):1335-9

Bachmaier, K., Neu, N., Yeung, RS (...) Liu, P., Penninger, JM. (1999). Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Circulation. 99(14):1885-91

Nishina, H., Vaz, C., Billia, P (...) Woodgett, JR., Penninger, JM. (1999). Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development. 126(3):505-16

Liu, Q., Oliveira-Dos-Santos, AJ., Mariathasan, S (...) Penninger, JM., Dumont, DJ. (1998). The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med. 188(7):1333-42

Kong, YY., Fischer, KD., Bachmann, MF (...) Ohashi, PS., Penninger, JM. (1998). Vav regulates peptide-specific apoptosis in thymocytes. J Exp Med. 188(11):2099-111

Matsumoto, G., Nghiem, MP., Nozaki, N., Schmits, R., Penninger, JM. (1998). Cooperation between CD44 and LFA-1/CD11a adhesion receptors in lymphokine-activated killer cell cytotoxicity. J Immunol. 160(12):5781-9

Penninger, JM., Kroemer, G. (1998). Molecular and cellular mechanisms of T lymphocyte apoptosis. Adv Immunol. 68:51-144

Molina, TJ., Perrot, JY., Penninger, J (...) Mak, TW., Diebold, J. (1998). Differential requirement for p56lck in fetal and adult thymopoiesis. J Immunol. 160(8):3828-34

Fischer, KD., Tedford, K., Penninger, JM. (1998). Vav links antigen-receptor signaling to the actin cytoskeleton. Semin Immunol. 10(4):317-27

Boyd, R., Kozieradzki, I., Chidgey, A (...) Mak, TW., Penninger, JM. (1998). Receptor-specific allelic exclusion of TCRV alpha-chains during development. J Immunol. 161(4):1718-27

Oliveira-dos-Santos, AJ., Penninger, JM., Rieker-Geley, T (...) Mak, TM., Wick, G. (1998). Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression. Eur J Immunol. 28(9):2882-92

Stambolic, V., Suzuki, A., de la Pompa, JL (...) Siderovski, DP., Mak, TW. (1998). Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 95(1):29-39

Nishina, H., Radvanyi, L., Raju, K (...) Kozieradzki, I., Penninger, JM. (1998). Impaired TCR-mediated apoptosis and Bcl-XL expression in T cells lacking the stress kinase activator SEK1/MKK4. J Immunol. 161(7):3416-20

Hakem, R., Hakem, A., Duncan, GS (...) Penninger, JM., Mak, TW. (1998). Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 94(3):339-52

Yoshida, H., Kong, YY., Yoshida, R (...) Penninger, JM., Mak, TW. (1998). Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell. 94(6):739-50

Penninger, JM., Mak, TW. (1998). Thymocyte selection in Vav and IRF-1 gene-deficient mice. Immunol Rev. 165:149-66

Fischer, KD., Kong, YY., Nishina, H (...) Bernstein, A., Penninger, JM. (1998). Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol. 8(10):554-62

Yoshida, H., Nishina, H., Takimoto, H (...) Crabtree, GR., Mak, TW. (1998). The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 8(1):115-24

Yao, Z., Diener, K., Wang, XS (...) Woodgett, JP., Penninger, JM. (1997). Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. J Biol Chem. 272(51):32378-83

Nishina, H., Bachmann, M., Oliveira-dos-Santos, AJ (...) Ohashi, PS., Penninger, JM. (1997). Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J Exp Med. 186(6):941-53

Penninger, JM., Sirard, C., Mittrücker, HW (...) Matsuyama, T., Mak, TW. (1997). The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. Immunity. 7(2):243-54

Marengère, LE., Mirtsos, C., Kozieradzki, I (...) Mak, TW., Penninger, JM. (1997). Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells. J Immunol. 159(1):70-6

Kozieradzki, I., Kündig, T., Kishihara, K (...) Mak, TW., Penninger, JM. (1997). T cell development in mice expressing splice variants of the protein tyrosine phosphatase CD45. J Immunol. 158(7):3130-9

Bachmaier, K., Pummerer, C., Kozieradzki, I (...) Neu, N., Penninger, JM. (1997). Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease. Circulation. 95(3):655-61

Wallace, VA., Penninger, JM., Kishihara, K (...) Ohashi, PS., Mak, TW. (1997). Alterations in the level of CD45 surface expression affect the outcome of thymic selection. J Immunol. 158(7):3205-14

Penninger, JM., Pummerer, C., Liu, P., Neu, N., Bachmaier, K. (1997). Cellular and molecular mechanisms of murine autoimmune myocarditis. APMIS. 105(1):1-13

Waterhouse, P., Bachmann, MF., Penninger, JM., Ohashi, PS., Mak, TW. (1997). Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice. Eur J Immunol. 27(8):1887-92

Bachmaier, K., Neu, N., Pummerer, C (...) Matsuyama, T., Penninger, JM. (1997). iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1. Circulation. 96(2):585-91

Nishina, H., Fischer, KD., Radvanyi, L (...) Woodgett, JR., Penninger, JM. (1997). Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature. 385(6614):350-3

Yeung, RS., Penninger, JM., Kündig, T (...) Kroemer, G., Mak, TW. (1996). Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: supersensitivity to superantigen-induced septic shock. Eur J Immunol. 26(5):1074-82

Amakawa, R., Hakem, A., Kundig, TM (...) Penninger, JM., Mak, TW. (1996). Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell. 84(4):551-62

Liu, P., Martino, T., Opavsky, MA., Penninger, J. (1996). Viral myocarditis: balance between viral infection and immune response. Can J Cardiol. 12(10):935-43

Penninger, JM., Wallace, VA., Molina, T., Mak, TW. (1996). Lineage-specific control of superantigen-induced cell death by the protein tyrosine kinase p56(lck). J Immunol. 157(12):5359-66

Pummerer, CL., Luze, K., Grässl, G (...) Penninger, JM., Neu, N. (1996). Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice. J Clin Invest. 97(9):2057-62

Pummerer, CL., Grässl, G., Sailer, M (...) Penninger, JM., Neu, N. (1996). Cardiac myosin-induced myocarditis: target recognition by autoreactive T cells requires prior activation of cardiac interstitial cells. Lab Invest. 74(5):845-52

Penninger, JM., Wen, T., Timms, E (...) Kronenberg, M., Mak, TW. (1995). Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice. Nature. 375(6528):241-4

Penninger, JM., Timms, E., Shahinian, A (...) Hedrick, SM., Mak, TW. (1995). Alloreactive gamma delta thymocytes utilize distinct costimulatory signals from peripheral T cells. J Immunol. 155(8):3847-55

Liu, P., Penninger, J., Aitken, K., Sole, M., Mak, T. (1995). The role of transgenic knockout models in defining the pathogenesis of viral heart disease. Eur Heart J. 16 Suppl O:25-7

Waterhouse, P., Penninger, JM., Timms, E (...) Griesser, H., Mak, TW. (1995). Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. 270(5238):985-8

Rieker, T., Penninger, J., Romani, N., Wick, G. (1995). Chicken thymic nurse cells: an overview. Dev Comp Immunol. 19(4):281-9

Wallace, VA., Kawai, K., Levelt, CN (...) Ohashi, PS., Eichmann, K. (1995). T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes. Eur J Immunol. 25(5):1312-8

Penninger, J., Rieker, T., Romani, N (...) Stössel, H., Wick, G. (1994). Ultrastructural analysis of thymic nurse cell epithelium. Eur J Immunol. 24(1):222-8

Ferrick, DA., Gemmell-Hori, L., Sydora, B (...) Kronenberg, M., Mak, TW. (1994). Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice. Int Rev Immunol. 11(4):295-304

Yeung, RS., Penninger, JM., Kündig, TM (...) Ohashi, PS., Mak, TW. (1994). Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function. J Exp Med. 180(5):1911-20

Yeung, RS., Penninger, J., Mak, TW. (1994). T-cell development and function in gene-knockout mice. Curr Opin Immunol. 6(2):298-307

Penninger, JM., Wallace, VA., Timms, E., Mak, TW. (1994). Maternal transfer of infectious mouse mammary tumor retroviruses does not depend on clonal deletion of superantigen-reactive V beta 14+ T cells. Eur J Immunol. 24(5):1102-8

Kimura, T., Nakayama, K., Penninger, J (...) Vilcek, J., Mak, TW. (1994). Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science. 264(5167):1921-4

Koh, DR., Ho, A., Rahemtulla, A., Penninger, J., Mak, TW. (1994). Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells. Eur J Immunol. 24(9):2250-3

Penninger, JM., Mak, TW. (1994). Signal transduction, mitotic catastrophes, and death in T-cell development. Immunol Rev. 142:231-72

Wallace, VA., Penninger, J., Mak, TW. (1993). CD4, CD8 and tyrosine kinases in thymic selection. Curr Opin Immunol. 5(2):235-40

Rieker, T., Penninger, J., Hala, K., Cooper, MD., Wick, G. (1993). In situ analyses of in ovo graft-vs.-host reaction induced by thymic nurse cell lymphocytes. Eur J Immunol. 23(4):904-10

Yeung, RS., Penninger, J., Mak, TW. (1993). Genetically modified animals and immunodeficiency. Curr Opin Immunol. 5(4):585-94

Kishihara, K., Penninger, J., Wallace, VA (...) Ohashi, PS., Thomas, ML. (1993). Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell. 74(1):143-56

Penninger, JM., Wallace, VA., Kishihara, K., Mak, TW. (1993). The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection. Immunol Rev. 135:183-214

Penninger, JM., Neu, N., Timms, E (...) Pummerer, C., Mak, TW. (1993). The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]. J Exp Med. 178(5):1837-42

Penninger, J., Kishihara, K., Molina, T (...) Hedrick, SM., Mak, TW. (1993). Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells. Science. 260(5106):358-61

Penninger, J., Wick, G. (1992). Thymic nurse cell lymphocytes react against self major histocompatibility complex. Eur J Immunol. 22(1):79-83

Wallace, VA., Fung-Leung, WP., Timms, E (...) Penninger, J., Mak, TW. (1992). CD45RA and CD45RBhigh expression induced by thymic selection events. J Exp Med. 176(6):1657-63

Wallace, VA., Rahemtulla, A., Timms, E., Penninger, J., Mak, TW. (1992). CD4 expression is differentially required for deletion of MLS-1a-reactive T cells. J Exp Med. 176(5):1459-63

Fedecka-Bruner, B., Penninger, J., Vaigot, P (...) Martínez, C., Kroemer, G. (1991). Developmental expression of IL-2-receptor light chain (CD25) in the chicken embryo. Dev Immunol. 1(3):237-42

Wick, G., Rieker, T., Penninger, J. (1991). Thymic nurse cells: a site for positive selection and differentiation of T cells. Curr Top Microbiol Immunol. 173:99-105

Penninger, J., Wallace, VA., Kishihara, K (...) Krause, H., Mak, TW. (1991). Molecular organization, ontogeny and expression of murine alpha beta and gamma delta T cell receptors. Exp Clin Immunogenet. 8(2):57-74

Cheng, SH., Penninger, JM., Ferrick, DA (...) Wallace, VA., Mak, TW. (1991). Biology of murine gamma delta T cells. Crit Rev Immunol. 11(3-4):145-66

Penninger, J. (1991). [Phenotypic and functional analysis of thymic nurse cell (TNC)-lymphocytes]. Wien Klin Wochenschr. 103(2):45-50

Penninger, J., Klima, J., Kroemer, G (...) Hala, K., Wick, G. (1989). Intra-thymic nurse cell lymphocytes can induce a graft-versus-host reaction with high efficiency. Dev Comp Immunol. 13(4):313-27