Jian Yi Kok

Current projects:

Project 1: Characterizing the role of Snf2-ATPase nucleosome remodellers in fission yeast

Since chromatin frequently needs to be restructured, a class of molecular motors – the Snf2-ATPase remodellers – have evolved in all eukaryotes to slide, evict and incorporate nucleosomes, which then results in an altered chromatin landscape. Currently, only limited information is available on the mechanisms and relationships between the different Snf2 ATPases, thus this project aims to shed insight into the functions and cellular pathways these remodeler proteins are involved in using fission yeast as a model organism.