Program

13:00  Registration

Keynote 1
14:00  Shamil Sunyaev, Harvard Medical School 
            Evolutionary and functional perspective on human polygenic traits            

Mutation and recombination (Chair: Molly Przeworski, Columbia University) 
15:00  Molly Przeworski
            Sources of germline mutation in humans

15:20  Laurent Duret, CNRS, Université Lyon 1
            High prevalence of Prdm9-independent recombination hotspots in placental mammals

15:40  Machiko Katori, The University of Tokyo
            Elucidating the Influence of Epigenetics on Local Mutation Rates and Its Impact on Genetic Adaptation

16:00  Marta Pelizzola, Aarhus University
            Integration of opportunities and parameterized signatures to improve estimation of mutational signatures for cancer data

16:30  Coffee Break

ARGs & population structure (Chair: Pier Palamara, Oxford University)
17:00  Pier Palamara
            Scalable inference and analysis of ancestral recombination graphs

17:20  Hrushikesh Loya, University of Oxford
            A method to find admixture with ghost populations using genome-wide genealogies

17:40  Iker Rivas-González, MPI Leipzig
            Distinguishing ancient introgression from incomplete lineage sorting with TRAILS v2

18:00  Jonathan Terhorst, University of Michigan
            Accelerated Bayesian inference of population size history from whole genome sequence data          

18:30  Dinner

20:00  Poster Session 1 & drinks

22:00  End

Molecular Evolution (Chair: Mikkel Heide Schierup, Aarhus University)
09:30  Mikkel Heide Schierup
            Gene conversions and recombinations inferred from HiFi long reads in humans, chimpanzees and gorillas

09:50  Richard Durbin, Cambridge University
            Estimating hybridisation dynamics between Yponomeuta ermine moth species

10:10  Hannah Munby, Columbia University
            Identifying long-lived balanced polymorphisms in humans

10:30  Sebastian Prillo, University of California, Berkeley
            CherryML and beyond: towards deep models of protein evolution

11:00  Coffee Break

Detecting selection (Chair: Elise Lauterbur, University of Arizona)
11:30  Elise Lauterbur
            Bayesian mediation models reveal patterns of host genomic disease adaptation driven by environment

11:50  Carina Mugal, Evol Biology, Lyon 1
            A framework for studying the impact of population-level processes on phylogenetic signatures of natural selection

12:10  Janek Sendrowski, Aarhus University
            PhaseGen - simulation and inference on exact solutions of coalescent distributions under diverse demographic scenarios

12:30  Hannes Svardal, University of Antwerp
            Ecolo-D - a framework for testing eco-evolutionary hypotheses on genetic introgression

13:00  Lunch

Phylogenetics (Chair: Sebastian Höhna, Ludwig-Maximilians-University, Munich)
14:00  Sebastian Höhna
            A population genetic and phylogenetic view on fireflies

14:20  Tomas Flouri, University College London
            Efficient Bayesian Inference Under the Multispecies Coalescent with Migration

14:40  Florian Massip, Mines Paris & Institut Curie
            Modeling the mosaic structure of bacterial genomes to infer their evolutionary history

15:00  Alexandre Lavarré, University of Lausanne
            A systematic approach to detect branch-specific positive selection in non-coding regulatory sequences

15:30  Coffee Break

Phylodynamics (Chair: Denise Kühnert, Robert Koch Institute, Berlin)
16:00  Denise Kühnert
            Towards recombination-aware phylodynamics

16:20  Hannah Götsch, University of Vienna
            The Hidden Impact of Sampling Bias in Prokaryotic Genomes

16:40  Bianca De Sanctis, University of Santa Cruz
            Correcting inferred pathogen genealogies from the effects of purifying selection

17:00  Anna Maria Langmüller, University of Vienna & Cornell University
            Gaussian Process Emulation: an application in epidemiology

Keynote 2
17:30  Mercedes Pascual, New York University
            Negative frequency-dependent selection and hyperdiversity in host-pathogen systems

18:30 Dinner

20:00  Poster Session 2 & drinks

22:00  End

Genomics (Chair: Brian Clarke, Deutsches Krebsforschungszentrum, Heidelberg)
09:30  Brian Clarke
            Integration of variant annotations using deep set networks boosts rare variant association genetics

09:50  Reka Borbely, IST Austria
            Optimal regimes of regulatory sequence evolution

10:10  Ragnhild Laursen, Aarhus University
            Non-negative spatial factorization for large single-cell transcriptomics

10:30  Julia Naas, CIBIV Vienna
            Developmental tree reconstruction in scRNA-seq data using phylogenetic inference

11:00  Coffee Break

Systems biology and AI/ML (Chair: Yun S. Song, University of California, Berkeley)
11:30  Yun S. Song
            DNA language models for genome interpretation: challenges and opportunities

11:50  Matthew Aguirre, Stanford University
            Gene regulatory network structure informs the distribution of perturbation effects

12:10  Matthew Robinson, IST Austria
            Light-speed inference of genetic effects via approximate message passing

12:30  Maria-Cristiana Girjau, Columbia University
            Explaining matched transcriptomic representations through interpretable deep canonical correlation analysis

13:00  Lunch

Microbiome & population structure (Chair: Anne-Florence Bitbol, EPFL, Lausanne)
14:00  Anne-Florence Bitbol
            Impact of population spatial structure on mutant fixation, from models on graphs to the gut

14:20  Nolan Kamitaki, Brigham & Women’s Hospital
            Host genetic effects on oral microbiome composition influence dental health

14:40  Xiaoqian Annie Yu, University of Vienna
            Genome-wide sweeps create fundamental adaptive units in the human gut microbiome

15:00  Arthur Zwaenepoel, CNRS – Evo-Eco-Paleo
            The genetic architecture of polygenic local adaptation and its role in shaping barriers to gene flow

15:30  Coffee Break

Quantitative genetics & genetic architecture (Chair: Hakhamanesh Mostafavi, NYU Grossmann School of Medicine)
16:00  Hakhamanesh Mostafavi
            Natural selection causes association studies to prioritize variant specificity over variant impact

16:20  Juliette de Meaux, University of Cologne
            Strength of purifying selection on the amino-acid sequence is associated with the amount of non-additive variance in gene expression

16:40  William Milligan, Columbia University
            When does adaptation arise from a polygenic response versus few large effect changes?

17:00  Roshni Patel, Stanford University
            Population genetics perspectives on complex trait architecture across populations

Keynote 3
17:30  Andrew Clark, Cornell University
            Heterochromatin and adaptive evolution

18:30  End of conference

19:00  Dinner @ Heurigen (optional)

22:00  End