Development and Evolution of Land Plants

Research focus

Our laboratory uses genetics to discover how plants and their cells develop and evolve. The main focus has been the identification of mechanisms that control the development and differentiation of specialised plant cell types. Using this information, we formulate testable hypotheses for how these mechanisms evolved during Earth history. Our current activity falls into three overlapping research areas:

Evolution of development: We use a combination of genetics and palaeontology to identify patterns in plant evolution and defining the molecular mechanisms that controlled the formation of land plant bodies soon after the colonisation of the land sometime around 500 million years ago. This research has identified the molecular mechanism that controlled the formation of the rooting structures that evolved among the first land plants that existed in the Ordovician Period.

De-novo polarity formation: We use a combination of genetics and imaging to define the mechanisms by which cells polarise from a non-polar state during the course of development. This programme focusses on the transformation of the apolar spore to a polarised cell which then undergoes a series of polarity-directed developmental decisions to form a mature plant.

Innovation: Our research to understand the evolution of developmental mechanisms of plant cells requires the development of new technologies. These technologies can be applied to other challenges in biology, medicine and agriculture. We bundled a set of enabling technologies into a spin-out company which develops crop protection products for agriculture. We continue to make use of our new knowledge to develop technologies that reduce the environmental impact of food production and improve human health.

 

News from the Dolan Lab

 

Selected Publications

Spencer V, Wallner ES, Jandrasits K, et al. (2024) Three-dimensional anatomy and dorsoventral asymmetry of the mature Marchantia polymorpha meristem develops from a symmetrical gemma meristem. Development 151(23):dev.204349 preprint bioRxiv:2024.08.23.609409.

Wallner ES and Dolan L (2024) Reproducibly oriented cell divisions pattern the prothallus to set up dorsoventrality and de novo meristem formation in Marchantia polymorpha. Current Biology 34(19):4357-67 preprint bioRxiv:2024.07.08.602509.

Attrill ST, Mulvey H, Champion C, et al. (2024) Microtubules and actin filaments direct nuclear movement during the polarisation of Marchantia spore cells. Development 151(20):dev202823 preprint bioRxiv:2024.02.23.581750.

Attrill ST and Dolan L (2024) KATANIN-mediated microtubule severing is required for MTOC formation and function in Marchantia polymorpha. Development 151(20):dev202672 preprint bioRxiv:2024.01.04.574198.

Mulvey H and Dolan L (2023) RHO of plant signaling was established early in streptophyte evolution. Curr Biol 33(24):5515-25.

Mulvey H and Dolan L (2023) ROP GTPase of plants regulates polarized cell growth and cell division orientation during morphogenesis. Curr Biol 33(14):2897-911 preprint bioRxiv:2023.05.23.541913.

 

Group members

Group Leader

Senior Postdocs

PhD Students

Bioinformaticians

Research Assistants

Interns and Master Students

Visiting Scientists