Ortrun Mittelsten Scheid


Dona M, Bradamante G, Bogojevic Z, et al. (2023) A versatile CRISPR-based system for lineage tracing in living plants. bioRxiv:2023.02.09.527713.

Durut N, Kornienko AE, Schmidt HA, et al. (2023) Long non-coding RNAs contribute to DNA damage resistance in Arabidopsis thaliana. bioRxiv:2023.03.20.533408

Mérai Z, Xu F, Musilek A, et al. (2023) Phytochromes mediate germination inhibition under red, far-red, and white light in Aethionema arabicum. Plant Physiol [epub] preprint bioRxiv:2022.06.24.497527.

Nguyen VH, Mittelsten Scheid O, Gutzat R (2023) Heat stress response and transposon control in plant shoot stem cells. bioRxiv:2023.02.24.529891.


Bradamante G, Nguyen VH, Incarbone M, et al. (2022) Two AGO proteins with transposon-derived sRNA cargo mark the germline in Arabidopsis. bioRxiv:2022.01.25.477718.

Incarbone M, Bradamante G, Pruckner F, et al. (2022) A hormone-activated mobile RNAi pathway defends plant stem cells from virus infection. bioRxiv:2022.12.18.520928.

Mittelsten Scheid O (2022) Mendelian and non-Mendelian genetics in model plants. Plant Cell 34(7):2455-61.

Schmitz RJ and Mittelsten Scheid O (2022) Editorial overview: COPB issue 2022 on "epigenetics and gene regulation". Curr Opin Plant Biol 70:102305.


Bente H, Foerster AM, Lettner N, et al. (2020) Polyploidy-associated paramutation in Arabidopsis is determined by small RNAs, temperature, and allele structure. PLoS Genet 17(3):e1009444 preprint bioRxiv:2020.10.21.348839.

Bradamante G, Mittelsten Scheid O, Incarbone M (2021) Under siege: virus control in plant meristems and progeny. Plant Cell 33(8):2523-7.

Capitao C, Tanasa S Fulnecek J, et al. (2021) A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis. PLoS Genet17(9):e1009779 preprint bioRxiv:2021.04.08.439068.

Fernandez-Pozo N, Metz T, Chandler JO, et al. (2021) Aethionema arabicum genome annotation using PacBio full-length transcripts provides a valuable resource for seed dormancy and Brassicaceae evolution research. Plant J 106(1):275-93.


Bente H, Mittelsten Scheid O, Donà M (2020) Versatile in vitro assay to recognize Cas9-induced mutations. Plant Direct 4(9):e00269.

Gutzat R and Mittelsten Scheid O (2020) Preparing Chromatin and RNA from Rare Cell Types with Fluorescence-Activated Nuclear Sorting (FANS). Methods Mol Biol 2093:95-105.

Gutzat R, Rembart K, Nussbaumer T, et al. (2020) Arabidopsis shoot stem cells display dynamic transcription and DNA methylation patterns. EMBO J 39(20):e103667 preprint bioRxiv:430447.


Dumur T, Duncan S, Graumann K, et al. (2019) Probing the 3D architecture of the plant nucleus with microscopy approaches: challenges and solutions. Nucleus 10(1):181-212.

Durut N and Mittelsten Scheid O (2019) The Role of Noncoding RNAs in Double-Strand Break Repair. Front Plant Sci 10:1155.

Mérai Z, Graeber K, Wilhelmsson P, et al. (2019) Aethionema arabicum: a novel model plant to study the light control of seed germination. J Exp Bot 70(12): 3313-28 preprint bioRxiv:470401.

Mittelsten Scheid O (2019) Illuminating (White and) Purple Patches. Plant Cell 31(6):1208-9.


Capitao C, Shukla N, Wandrolova A, et al. (2018) Functional Characterization of SMG7 Paralogs in Arabidopsis thaliana. Front Plant Sci 9:1602.

Dubin MJ, Mittelsten Scheid O, Becker C (2018) Transposons: a blessing curse. Curr Opin Plant Biol 42:23-9.


Mittelsten Scheid O (2017) Nicht-Mendelsche Genetik. Nova Acta Leopoldina NF 413: 231-250.

Bente H and Mittelsten Scheid O (2017) Epigenetic contribution to diversification. Proc Natl Acad Sci USA 114(14):3558-60.

Lenser T, Graeber K, Cevik ÖS, et al. (2016) Developmental control and plasticity of fruit and seed dimorphism in the brassica Aethionema. Plant Physiol 172(3):1691-707.

Dona M, Mittelsten Scheid O (2015) DNA damage repair in the context of plant chromatin. Plant Physiol 168(4):1206-18.

Mittelsten Scheid O (2015) Editorial. Semin Cell Dev Biol.44:1.

Probst AV, Mittelsten Scheid O (2015) Stress-induced structural changes in plant chromatin. Curr Opin Plant Biol 27:8-16.

Baubec T, Finke A, Mittelsten Scheid O, et al. (2014) Meristem-specific expression of epigenetic regulators safeguards transposon silencing in Arabidopsis. EMBO Rep 15(4):446–52.

Cavrak VV, Lettner N, Jamge S, et al. (2014) How a Retrotransposon Exploits the Plant's Heat Stress Response for Its Activation. PLoS Genet 10(1): e1004115.

Pikaard CS, Mittelsten Scheid O (2014) Epigenetic regulation in plants. Cold Spring Harb Perspect Biol 6(12): a019315.

Rosa M, Von Harder M, Cigliano RA, et al. (2013) The Arabidopsis SWR1 Chromatin-Remodeling Complex Is Important for DNA Repair, Somatic Recombination, and Meiosis. Plant Cell 25(6): 1990-2001.

Dinh HQ, Dubin M, Sedlazeck FJ, et al. (2012) Advanced methylome analysis after bisulfite deep sequencing: An example in Arabidopsis. PLoS ONE 7: e41528.

Gutzat R, Mittelsten Scheid O (2012) Epigenetic responses to stress: triple defense? Curr Opin Plant Biol 15:1–6.

Pecinka A, Mittelsten Scheid O (2012) Stress-induced chromatin changes: a critical view on their heritability. Plant Cell Physiol 53:801-8.

Förster A, Dinh H, Sedman L, et al. (2011) Genetic rearrangements can modify chromatin features at epialleles. PLoS Genet 7(10):e1002331.

Pecinka A, Fang W, Rehmsmeier M, et al. (2011) Polyploidization increases meiotic recombination frequency in Arabidopsis. BMC Biol 9:24.

Baubec T, Dinh HQ, Pecinka A, et al. (2010) Cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic states in Arabidopsis. Plant Cell 22(1):34-47.

Yokthongwattana C, Bucher E, Caikovski M, et al. (2010) MOM1 and Pol-IV/V interactions regulate the intensity and specificity of transcriptional gene silencing. EMBO J 29(2):340-51.

Pecinka A, Dinh HQ, Baubec T, et al. (2010) Epigenetic regulation of repetitive elements is attenuated by prolonged heat stress in Arabidopsis. Plant Cell 22(9):3118-29.

Köhler C, Mittelsten Scheid O, Erilova A (2010) The impact of the triploid block on the origin and evolution of polyploid plants. Trends Genet 26(3):142-8.

Förster AM, Mittelsten Scheid O (2010) Analysis of DNA methylation in plants by bisulfite sequencing. Methods Mol Biol 631:1-11.

Förster AM, Hetzl J, Müllner C, et al. (2010) Analysis of bisulfite sequencing data from plant DNA using CyMATE. Methods Mol Biol 631:13-22.

Dhawan R, Luo H, Förster AM, Abuqamar S, Du HN, Briggs SD, Mittelsten Scheid O, Mengiste T (2009) HISTONE MONOUBIQUITINATION1 interacts with a subunit of the mediator complex and regulates defense against necrotrophic fungal pathogens in Arabidopsis. Plant Cell 21:1000-1019.

Erilova A, Brownfield L, Exner V, Rosa M, Twell D, Mittelsten Scheid O, Hennig L, Köhler C (2009) Imprinting of the polycomb group gene MEDEA serves as a ploidy sensor in Arabidopsis. PLoS Genet 5:e1000663.

Pecinka A, Rosa M, Schikora A, Berlinger M, Hirt H, Luschnig C, Mittelsten Scheid O (2009) Transgenerational stress memory is not a general response in Arabidopsis. PLoS ONE 4:e5202.

Baubec T, Pecinka A, Rozhon W, Mittelsten Scheid O (2008) Effective, homogeneous and transient interference with cytosine methylation in plat genomic DNA by zebularine. Plant J 57:542-554.

Rozhon W, Baubec T, Mayerhofer J, Mittelsten Scheid O, Jonak C (2008) Rapid quantification of global DNA methylation by isocratic cation-exchange high-performance liquid chromatography. Anal Biochem 375:354-360.

Hetzl J, Förster AM, Raidl G, Mittelsten Scheid O (2007) CyMATE: a new tool for methylation analysis of plant genomic DNA after bisulfite sequencing. Plant J 51:526-536.

Ono T, Kaya H, Takeda S, et al. (2006) Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis. Genes Cells 11(2):153-62.

Matzke M, Mittelsten Scheid O (2006) Epigenetic regulation in plants. In: Epigenetics (eds. Allis CD, Jenuwein T, Reinberg D), Cold Spring Harbor Laboratory Press, pp. 167-189.

Baubec T, Mittelsten Scheid O (2006) Medea in full self control. Trends Plant Sci 11:469-471.

Stam M, Mittelsten Scheid O (2005) Paramutation: an encounter leaving a lasting impression. Trends Plant Sci 10:283-290.

Takeda S, Tadele Z, Hofmann I, Probst AV, Angelis KJ, Kaya H, Araki T, Mengiste T, Mittelsten Scheid O, Shibahara K, Scheel D, Paszkowski J (2004) BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis. Genes Dev 18:782-793.

Mittelsten Scheid O (2004) Either/or selection markers for plant transformation. Nat Biotechnol 22:398-399.

Probst AV, Fagard M, Proux F, Mourrain P, Boutet S, Earley K, Lawrence RJ, Pikaard CS, Murfett J, Furner I, Vaucheret H, Mittelsten Scheid O (2004) Arabidopsis histone deacetylase HDA6 is required for maintenance of transcriptional gene silencing and determines nuclear organization of rDNA repeats. Plant Cell 16:1021-1034.

Probst AV, Fransz PF, Paszkowski J, Mittelsten Scheid O (2003) Two means of transcriptional reactivation within heterochromatin. Plant J 33:743-749.

Saze H, Mittelsten Scheid O, Paszkowski J (2003) Maintenance of CpG methylation is essential for epigenetic inheritance during plant gametogenesis. Nat Genet 34:65-69.

Mittelsten Scheid O, Afsar K, Paszkowski J (2003) Formation of stable epialleles and their paramutation-like interaction in tetraploid Arabidopsis thaliana. Nat Genet 34:450-454.

Mittelsten Scheid O, Probst AV, Afsar K, Paszkowski J (2002) Two regulatory levels of transcriptional gene silencing in Arabidopsis. Proc Natl Acad Sci USA 99:13659-13662.

Ulm R, Mittelsten Scheid O (2002) Tailor-made toxin targets. Trends in Plant Sciences 7:196-7.

Ulm R, Mittelsten Scheid O (2001) A hairy tale: Glabrous meets Werewolf. Trends in Plant Sciences 6:343.

Amedeo P, Habu Y, Afsar K, et al. (2000) Disruption of the plant gene MOM releases transcriptional silencing of methylated genes. Nature 405:203-6.

Ulm R, Mittelsten Scheid O (2000) A conduit for T-DNA through the plant cell membrane: dig it yourself! Trends in Plant Sciences 5:514.

Mittelsten Scheid O, Paszkowski J (2000) Transcriptional gene silencing mutants. Plant Molecular Biology 43:235-1.

Steimer A, Amedeo P, Afsar K, et al. (2000) Endogenous targets of transcriptional gene silencing in Arabidopsis. Plant Cell 12:1165-78

Mittelsten Scheid O (1999) Plant viruses. New tools for Swiss army knife. Nature 397:25.

Matzke MA, Mittelsten Scheid O, Matzke AJM (1999) Rapid structural and epigenetic changes in polyploid and aneuploid genomes. BioEssays 21:761-7.

Mittelsten Scheid O, Afsar K, Paszkowski J (1998) Release of epigenetic silencing by trans-acting mutations in Arabidopsis. Proc Nat Acad Sci USA 95:532-7

Diéguez MJ, Vaucheret H, Paszkowski J, et al. (1998) Cytosine methylation at CG and CNG sites is not a prerequisite for the initiation of transcriptional gene silencing in plants but it is required for its maintenance. Molecular and General Genetics 259:207-15

Paszkowski J, Mittelsten Scheid O (1998) Plant genes: The genetics of epigenetics. Curr Biol 8:R206-8.

Diéguez MJ, Bellotto M, Afsar K, et al. (1996) Methylation of cytosines in nonconventional methylation acceptor sites contributes to reduced gene expression. Molecular and General Genetics 253:581-8.

Mittelsten Scheid O, Jakovleva L, Afsar K, Maluszynska Y, Paszkowski J (1996) A change of ploidy can modify epigenetic silencing. Proc Nat Acad Sci USA 93:7114-9.

Mittelsten Scheid O, Neuhaus-Url G (1995) The detection of neomycin phosphotransferase activity in plant extracts. In: Agrobacterium Protocols. KMA Gartland, MR Davey (eds.) Methods in Molecular Biology Vol. 44, Humana Press, Totowa, pp. 201-6

Fütterer J, Gisel A, Iglesias VA, et al. (1995) Standard molecular techniques for the analysis of transgenic plants. In: Gene Transfer to Plants. I Potrykus, G Spangenberg (eds.) Springer Verlag, Berlin, pp. 215-63

Mittelsten Scheid O, Afsar K, Paszkowski J (1994) Gene inactivation in Arabidopsis thaliana is not accompanied by an accumulation of repeat-induced point mutations. Molecular and General Genetics 244:325-30.

Ermak G, Paszkowski U, Wohlmuth M, et al. (1993) Cytosine methylation inhibits replication of African cassava mosaic virus by two distinct mechanisms. Nucleic Acids Research 21:3445-50.

Iida S, Mittelsten Scheid O, Saul MW, et al. (1992) Expression of a downstream gene from a bicistronic transcription unit in transgenic tobacco plants. Gene 119:199-205

Mittelsten Scheid O, Paszkowski J, Potrykus I (1991) Reversible inactivation of a transgene in Arabidopsis thaliana. Molecular and General Genetics 228:104-12.

Karesch H, Bilang R, Mittelsten Scheid O, et al. (1991) Direct gene transfer to protoplasts of Arabidopsis thaliana. Plant Cell Reports 9:571-4.