Yasin Dagdas

Autophagy mediated cellular quality control mechanisms in plants

The Dadgas Lab is recruiting a postdoc

Research Focus

Quality control pathways are essential for sustaining multicellular life in an ever-changing environment. By promptly tailoring the cellular proteome and organelles in a cell-type specific manner, they maintain the ability to respond to external changes, thereby maximizing organismal fitness. Selective autophagy is a potent quality control pathway that recycles damaged or unwanted macromolecules to keep cells healthy and in tune with the environment. So far, most of our insights into selective autophagy are derived from studies that utilize in vitro cell cultures. Addressing how selective autophagy contributes to cellular homeostasis in different cell types, and how this translates into overall performance of the organism, is extremely challenging and has therefore remained elusive. Our goal is to employ a multidisciplinary approach to study the role of selective autophagy in cellular quality control at a cell-type specific resolution.

Selected Publications

Zess E, Jensen C, ..., Dagdas Y (2018) N-terminal β-strand underpins biochemical specialization of an ATG8 isoform. bioRxiv:453563.

Dagdas YF, Pandey P, Tumtas Y, et al. (2018) Host autophagy machinery is diverted to the pathogen interface to mediate focal defense responses against the Irish potato famine pathogen. Elife 2018;7:e37476 preprint bioRxiv:102996.

Pötsch I, Ebner P, Deszcz L, et al. (2018) The anti-apoptosis ubiquitin E3 ligase XIAP promotes autophagosome-lysosome fusion during autophagy. bioRxiv:291294.

Dagdas YF, Belhaj K, Maqbool A, et al. (2016) An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor. Elife e10856.

Maqbool A, Hughes RK, Dagdas YF, et al. (2016) Structural Basis of Host Autophagy-related Protein 8 (ATG8) Binding by the Irish Potato Famine Pathogen Effector Protein PexRD54. J Biol Chem 291(38):20270-82.