Pursuing a PhD is a transformative step in a scientific career, offering the opportunity to explore a research area deeply while honing critical thinking skills. The right environment – supportive mentors, cutting-edge resources, and a vibrant research community – can make all the difference in shaping a successful experience. In this interview, we speak with two PhD students at the GMI about their experiences, their challenges, and their reasons for undertaking a PhD. 

Julia Kober joined Silvia Ramundo’s lab as an intern after obtaining a Master’s Degree in Molecular Biology from the University of Vienna. In 2023, Julia was selected by the Vienna BioCenter PhD Program. Her PhD project is co-supervised by Thomas Leonard at the Max Perutz Labs, also at the Vienna BioCenter. 

Alessia Del Chiaro obtained a Master’s Degree in Molecular Biology from the University of Pisa. In 2022, she joined the lab of Yasin Dagdas through the Vienna BioCenter PhD Program. 

Why did you decide to pursue a PhD at the GMI and the Vienna BioCenter? 

Julia Kober: I enjoyed my internships at the Max Perutz Labs and the GMI so much that I decided to stay for my PhD. 

Alessia Del Chiaro: My Master’s program supervisor participated in the Ubiquitin & Friends Symposium held at the Vienna BioCenter. Impressed by the scientific environment on campus, he encouraged me to apply for the PhD Program. 

What are you investigating in your PhD project? 

Alessia Del Chiaro: I investigate how autophagy, the cell’s cleanup process, can promote regeneration by inducing a cellular “reset” into a stem cell-like state. You can imagine this “reset” to be like a factory reset on your smartphone. 

Julia Kober: Our lab studies chloroplast biogenesis and protein quality control. My research focuses on the only known signaling player in the chloroplast unfolded protein response, the MARS1 kinase, and its role in maintaining chloroplast proteostasis.  

How has the Vienna BioCenter community contributed to your project?  

Julia Kober: The high density of research groups and the level of collaboration offer many learning opportunities. For instance, being co-supervised by group leaders at the GMI and the Max Perutz Labs allows me to seamlessly integrate two disciplines into my project. 

Alessia Del Chiaro: Sharing my research through GMI and Vienna BioCenter seminars, I have received excellent feedback from both peers and more experienced colleagues, enriching my research and broadening my scientific perspective. 

How have the core facilities supported your research? 

Alessia Del Chiaro: The core facilities allow easy access to different state-of-the-art technologies and services, one of the major advantages of working at the Vienna BioCenter. The BioOptics facility trained me on advanced microscopy techniques and offered invaluable support in addressing technical challenges. 

Julia Kober: Having access to professional facilities and their expert staff is an incredible resource. They are happy to explain everything in detail to ensure we learn how to produce high-quality data. In particular, the Protein Technologies Facility and the Mass Spectrometry Facility have helped my project tremendously.  

How have the PhD program and your colleagues impacted your development as a scientist? 

Julia Kober: By leading a research project, I have developed organization, communication and mentorship skills essential for my professional future. In addition, my research group has built an amazing lab environment where everyone can learn from each other and contribute their expertise to collaborative projects. 

Alessia Del Chiaro: The program offers an excellent balance of formal training and hands-on research experience, with a diverse range of courses that help students acquire new skills. In addition, Yasin’s guidance has been instrumental in shaping my project and allowing me to develop my own ideas and approach.  

What have been the most challenging and rewarding parts of doing a PhD?  

Julia Kober: I was surprised by how much planning is needed for a research project to be successful. However, I improved my organization skills and learned to step out of my comfort zone and take challenges head-on. 

Alessia Del Chiaro: Balancing my expectations with the demanding PhD process has been challenging, but I’ve learned to stay focused on my long-term goals and keep going. On the other hand, gaining scientific independence and making new discoveries has been very rewarding. 

What has been the favorite part of your PhD so far? 

Alessia Del Chiaro: The many social events on campus, such as the yearly GMI retreat, provide great opportunities for building connections. In addition, the campus offers access to sports and other activities, which help researchers maintain a healthy work-life balance. 

Julia Kober: Presenting my research for the first time at the institute’s yearly retreat was nerve-wracking but rewarding, especially the positive feedback I received on my work. Spending time with my colleagues outside the lab has also been a highlight, whether it's attending the Friday Social Hours or playing beach volleyball during the summer.