Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far. A new multi-chamber organoid that mirrors the heart’s intricate structure…

Does the human brain have an Achilles heel that ultimately leads to Autism? With a revolutionizing novel system that combines brain organoid technology and intricate genetics, researchers can now comprehensively test the effect of multiple mutations…

Scientists have known for decades that genes can be transferred from one species to another, both in animals and plants. However, the mechanism of how such an unlikely event occurs remained unknown. Now, researchers from Alejandro Burga’s lab at the…

Researchers from the Tachibana lab show that the pioneer factor Nr5a2 can awaken the inactive genome in the early embryo. Part of this work was carried out at IMBA before the Tachibana lab moved to the Max Planck Institute of Biochemistry (MPIB). The…

In their latest Nature publication, researchers from the Gerlich Group at IMBA determined the molecular mechanisms that confer special physical properties to mitotic chromosomes to prevent their entanglement with microtubules of the spindle. In this…

With the help of cerebral organoids, IMBA scientists were able to ascertain that Tuberous Sclerosis, a rare neurodevelopmental genetic disorder, arises developmentally rather than only genetically. With these patient-derived laboratory models of the…

The development of human blastoids, human embryo models at IMBA, paves the way for improving in vitro fertilization success rate and new non-hormonal, user-friendly contraception. This breakthrough from the Rivron lab is now published in the journal…