Flavins and Flavoproteins 1987 : : Proceedings of the Ninth International Symposium, Atlanta, Georgia, USA, June 7–12, 1987 / / ed. by D. E. Edmondson, D. B. McCormick.

• Superior document: Title is part of eBook package: De Gruyter DGBA Physical Sciences <1990
• MitwirkendeR: Ackrell, Brian A. C.,; Aliverti, A.,; Anderson, Robert F.,; Aral, Ryohachi,; Armstrong, D. A.,; Arscott, L. David,; Astorga, Adrienne M.,; Bacher, Adelbert,; Bakx, Edwin J.,; Baldwin, T. O.,; Baldwin, Thomas O.,; Ballou, D. P.,; Ballou, David P.,; Ballou, David,; Barber, M. J.,; Bartsch, R. G.,; Bastiaens, Phil,; Batie, Christopher J.,; Becker, K.,; Beintema, Jaap J.,; Bellamy, H. D.,; Berkel, Willem J. H. van,; Berkel, Willem J.H. van,; Berry, A.,; Blanchard, J. S.,; Bohmont, Craig,; Bonants, Peter,; Bowers-Komro, D. M.,; Bowers-Komro, Delores M.,; Brandsch, Roderich,; Breakefield, Xandra O.,; Brissette, Pierre,; Brown, Kathleen,; Bryant, Christopher,; Byron, Colleen M.,; Casalin, P.,; Cecchini, Gary,; Chastain, J. L.,; Cheddar, Glen,; Chen, L. H.,; Chen, Shiuan,; Chikako, Chikako,; Chlumsky, L. J.,; Churchich, Jorge E.,; Claiborne, Al,; Cochran, Bruce,; Corey, David P.,; Curti, B.,; Cusanovich, M. A.,; Cusanovich, Michael A.,; Daubner, Susan Colette,; De Francesco, R.,; De Francesco, Raffaele,; De la Rosa, M . A .,; DeLuca, Marlene,; Decker, Karl,; Devine, J. H.,; Distefano, M.,; Distefano, Mark D.,; Drake, Donna M.,; Drenth, Jan,; Dutta, P.,; Eckstein, Jens,; Edmondson, D. E.,; Edmondson, Dale E.,; Einarsdottir, G. H.,; Eisenreich, Wolfgang,; Ellison, Patricia A.,; Engel, Paul C.,; Engelke, David R.,; Ermler, Ulrich,; Fauque, G.,; Fillat, M. F.,; Fillat, M.,; Fish, Kenneth M.,; Florence, Lederer,; Floss, Heinz G.,; Fukui, Kiyoshi,; Galliano, N.,; Ghisla, Sandra,; Ghisla, Sandro,; Ghislat, Sandro,; Giegel, David A.,; Gomez-Moreno, C.,; Grandori, R.,; Green, Jacalyn M.,; Gustafson, William G.,; Gómez-Moreno, C.,; Gückel, F.,; Hall, Carole L.,; Hall, D. O.,; Hazzard, James T.,; Hederstedt, L.,; Heelis, P. F.,; Hille, Russ,; Hinkkanen, Ari E.,; Hoek, Arie van,; Hoi, Wim G. J.,; Hol, Win G. J.,; Holden, H. M.,; Horiike, Kihachiro,; Hsu, Yun-Pung P.,; Hubera, Robert,; Husain, Mazhar,; Ichihara, Chikako,; Inagaki, Taisuke,; Innis, W. S. A.,; Innis-Whitehouse, W. S. A.,; Ishii, Yasuhiko,; Jekel, Peter A.,; Johnston, T. C.,; Jorns, Marilyn Schuman,; Jörns, Marilyn Schuman,; Kaiczyk, G. B.,; Kalk, Kor H.,; Karplus, P. A.,; Kasai, Sabu,; Kawamura-Konishi, Y.,; Kawamura-Konishi, Yasuko,; Kay, C. J.,; Kearney, Edna B.,; Keller, Paul J.,; Kim, J. J. P.,; Klapper, Michael H.,; Kodo, Keiun,; Koerber, Steven C.,; Kok, Arie de,; Koshizaka, Takuya,; Koyama, H.,; Kozioł, J.,; Krauth-Siegel, R. L.,; Krey, Grigorios D.,; Kvalnes-Krick, Kalla,; Kwok, Francis,; König, Astrid,; Laan, Jan M. van der,; Labeyrie, F.,; Ladensteina, Rudolf,; Lau, S-M.,; Laudenbach, David E.,; Le Vana, Quang,; LeGall, J.,; Lederer, F.,; Lee, J.,; Lee, James S.,; Lee, John,; Leisman, Gary,; Lim, L. W.,; Lin, J.-W.,; Lindskog, S.,; Lively, Chris R.,; Ludwig, Martha L.,; Macheroux, Peter,; Maeda, Toshihiro,; Mager, Humphrey I. X.,; Manstein, D. J.,; Manstein, Dietmar J.,; Markley, John L.,; Martin, Tracy,; Massey, V.,; Massey, Vincent,; Mathews, F. S.,; Matsuara, Hiroshi,; Matsui, Kunio,; Matthews, Rowena G.,; Mauch, Ludwig,; Mayhew, Stephen G.,; Mayhew, Steve G.,; McCormick, D. B.,; McCormick, Donald B.,; McFarland, James T.,; McWhirter, Robert B.,; Mclntire, W. S.,; Mclntire, William S.,; Merrill, A. H.,; Meyer, T. E.,; Meyer, Terrance E.,; Mierlo, Carlo P.M. van,; Mierlo, Carlo van,; Miiller, Franz,; Miller, S. M.,; Miura, R.,; Miyake, Y.,; Miyake, Yoshihiro,; Momoi, Kyoko,; Moore, M.,; Moore, Melissa J.,; Moura, I.,; Moura, J. J. G.,; Muller, F.,; Murata, M.,; Müller, Franz,; Nagata, T.,; Nagursky, Heiner,; Nakamura, Makoto,; Nakamura, Takao,; Negri, Armando,; Neujahr, Haiina Y.,; Neujahr, Halina Y.,; Nishikimi, Morimitsu,; Nishina, Yasuzo,; Nishino, T.,; Nishino, Takeshi,; Nishino, Tomoko,; Nishiyama, Kyoko,; Nisimoto, Y.,; Nitta, Satoshi,; Nozaki, Mitsuhiro,; Ohishi, Nobuko,; Ohnishi, Norihiro,; Oka, M.,; Ozawa, Takayuki,; O’Kane, D. J.,; O’Kane, Dennis J.,; O’Nuallain, Eoin M.,; Pai, E. F.,; Pai, Emil F.,; Pattridge, Katherine A.,; Peck, H. D.,; Perham, R. N.,; Pinto, J. T.,; Pollegioni, L.,; Poole, Leslie B.,; Poulsen, L. L.,; Powell, John,; Powell, P. J.,; Powlowski, Justin,; Prongay, Andrew J.,; Pueyo, J. J.,; Pust, Stefan,; Ramsay, Rona R.,; Rao, K. K.,; Ratti, S.,; Rayment, I.,; Rivlin, R. S.,; Ronchi, S.,; Sahlman, Lena,; Saint-Martin, P.,; Saito, T.,; Sancho, J.,; Sandström, A.,; Schirmer, R. H.,; Schneider, Monika,; Schopfer, Lawrence M.,; Schott, Karin,; Schreuder, Herman A.,; Schulz, G. E.,; Schulz, Georg E.,; Schwarzkopf, Bruno,; Schweitzer, D.,; Schöllhammer, T.,; Scrutton, N. S.,; Sejlitz, Torsten,; Shibata, Toshihiro,; Shiga, Kiyoshi,; Simonetta, M. Pilone,; Singer, T. P.,; Singer, Thomas P.,; Solomonson, L. P.,; Staab, H. A.,; Stankovich, M. T.,; Stankovich, Marian T.,; Steenkamp, D. J.,; Stewart, D. E.,; Stockman, Brian J.,; Straus, Neil A.,; Sugihara, J.,; Surdhar, P. S.,; Suzuki, H.,; Suzuki, Haruo,; Swarte, Myra B. A.,; Swenson, Richard P.,; Szafran, M. M.,; Takeshima, Katsuhito,; Taylor, K. L.,; Taylor, M. G.,; Tegoni, M.,; Thorpe, C.,; Thorpe, Colin,; Thunnissen, Marjolein M. G. M.,; Titlow, Christian,; Tojo, Hiroaasa,; Tojo, Hiromasa,; Tollin, Gordon,; Tsukagoshi, Norihiro,; Tsushima, K.,; Tsushima, Keizo,; Tu, S.-C.,; Tu, Shiao-Chun,; Udaka, Shigezo,; Urban, Philippe,; Ushijiaa, Hidetaka,; Utterback, Margot,; Van Beeumen, J.,; Vanin, Elio F.,; Vanoni, M. A.,; Vervoort, J.,; Vervoort, Jacques,; Visser, Antonie J. W. G.,; Visser, Antonie J.W.,; Visser, Ton,; Volka, Rainer,; Waddle, J. J.,; Walker, Mark C.,; Walsh, C. T.,; Walsh, Christopher T.,; Wampler, J. E.,; Wang, L.-H.,; Wang, Lee-Ho,; Watanabe, Fusao,; Weiner, P. K.,; Westphal, Adrie H.,; Weyer, Wicher J.,; Weyler, Walter,; Wierenga, Rik K.,; Williams, C. H.,; Williams, Charles H.,; Wong, K. K.,; Wu, J.,; Xavier, A. V.,; Xia, Z. -x.,; Yagi, Kunio,; Yamano, Toshio,; Yamazaki, K.,; Yoshikawa, Shinya,; Yu, Yimin,; Zanetti, G.,; Zeller, Hans-Dieter,; Zhou, Jing-Zhi,; Ziegler, M. M.,; Zipplies, M. F.,
• HerausgeberIn: Edmondson, D. E.,; McCormick, D. B.,
• Place / Publishing House: Berlin ;, Boston : : De Gruyter, , [2019]; ©1987
• Year of Publication: 2019
• Edition: Reprint 2019
• Language: English
• Physical Description: 1 online resource (XXIII, 775 p.) :; Num. figs.

Table of Contents

Frontmatter -- Preface -- Organizing committee -- Acknowledgements -- Contents -- STRUCTURE AND MECHANISMS OF FLAVOENZYMES -- Absolute stereochemistry of flavins in enzyme - catalyzed reactions -- Conserved cysteine pairs of mercuric ion reductase: an investigation of function via site-directed mutagenesis -- Reduced forms of native mercuric reductase and their reactions with mercuric compounds - activity vs inhibition -- Rapid-scan stopped-flow studies of the flavoenzyme mercuric reductase during catalytic turnover -- The penultimate cysteines in mercuric reductase aid in the reduction of mercury -- The active center of glutathione reductase at 1.54 A resolution -- Kinetic isotope effect studies on yeast, spinach and human erythrocyte glutathione reductases -- Excited electronic states of flavin-containing coenzyme models -- Trypanothione reductase from Trypanosoma cruzi -- Inactivation of two-electron reduced Escherichia coll glutathione reductase by NADPH and NADH -- Studies on the active site of human erythrocyte glutathione reductase using 6-SCN-FAD and 6-mercapto - FAD -- Protein engineering of glutathione reductase from Escherichia coli -- Studies on the active sites of lipoamide dehydrogenase and glutathione reductase -- Cloning, organisation and nucleotide sequence of the Azotobacter vinelandii gene for lipoamide dehydrogenase -- Reaction of pig heart lipoamide dehydrogenase with monobromoacetone and 1,3-dibromoacetone -- Site-directed mutagenesis of thioredoxin reductase -- Effects of urea on redox properties of streptococcal NADH peroxidase -- Three dimensional structure of baker's yeast flavocytochrome b2 -- Mechanism of L-lactate dehydrogenation catalyzed by flavocytochrome b.2 from baker's yeast -- Inactivation of yeast flavocytochrone b.2 with fluoropyruvate. Modification of the active site histidine -- Evidence for an alteration of the flavin behavior induced by 2-methyl - 2,4 - pentandiol in cerevis iae flavocytochrome b2 -- Medium chain acyl-CoA dehydrogenase from pig kidney: Aspects of the reductive half - reaction -- Crystal structure of the general acyl-CoA dehydrogenase -- Inactivation of general acyl-CoA dehydrogenase from pig k i dney by the suicide substrate methylenecyclopropylacetyl - CoA. Stucture of one of the covalent flavin-inhibitor adducts -- 2 - Bromo-octanoyl CoA: Apseudo-substrateforgeneral acyl-CoA dehydrogenase -- Reaction of pig kidney medium chain acyl-CoA dehydrogenase with ^ - oxidation intermediates -- Medium chain acyl-CoA dehydrogenase from pig kidney: I n activation of the reduced enzyme by 2-octynoy1-CoA -- Oxidation - reduction of general acyl-CoA dehydrogenase by the butyryl-CoA / crotonyl-CoA couple. A new investigation of the rapid reaction kinetics -- Catalytic versatility of butyryl-CoA dehydrogenase from M. elsdenii -- Oxidation-reduction potential of glutaryl-CoA dehydrogenase from Paracoccus denitrifleans -- 13C NMR studies on the complexes and reaction intermediates of D-amino acid oxidase -- 13C-,15N-, and 31P- NMR studies on 6-hydroxy-L-nicotine oxidase from Arthrobacter oxidans -- A study on the interaction between reduced D-amino acid oxidase and ligands -- D-Amino acid oxidase from the yeast Rhodotorula gracilis -- Purification and properties of D-aspartate oxidase from beef kidney -- Spectral and kinetic studies on Pseudomonas L-phenylalanine oxidase (deaminating and decarboxylating) -- Time - resolved flavin fluorescence of pyridoxine-5-P oxidase from sheep brain -- An active site thiol in lactate oxidase -- Can methylenetetrahydrofolate reductase be used to evade the methyl trap? -- The catalytic mechanism of DNA photolyase -- FLAVOENZYME STRUCTURE AND ELECTRON TRANSFER MECHANISMS -- Sequence and structure of Anacvstis nidulans flavodoxin: Comparisons with flavodoxins from other species -- C-13, N-15, and two-dimensional NMR techniques in flavoprotein research -- Two dimensional NMR studies on Megasphaera elsdenii -- Flavodoxin from Anabaena 7120: Uniform N-15 enrichment and nitrogen-15 and phosphorus - 31 NMR investigations of the FMN binding site in the reduced and oxidized states -- Pulse radiolysis studies on flavodoxin -- Resonance raman investigations of flavins and flavoproteins -- Spectral studies on hydrogen bonded alloxazines -- Use of flavin and flavodoxin semiquinones as kinetic probes to elucidate the factors which determine reaction rate constants and biological specificity for electron transfer proteins -- Factors influencing the rate of electron transfer from flavodoxin to cytochrome c. -- A computer graphics model of the complex formed between flavodoxin and the tetraheme cytochrome c.3 -- Cloning and nucleotide sequence of a bacterial flavodoxin gene: Towards the site-directed mutagenesis of the flavin binding site -- Flavin binding site differences between Photobacterium phosphoreum lumazine protein and Megasphaera elsdenii flavodoxin. An investigation using circular dichroism and fluorescence -- Ferredoxin and ferredoxin-NADP+oxidoreductase interactions: Mapping of their binding sites -- Complex formation between ferredoxin-NADP+-oxidoreductase and flavodoxin -- Mechanism of ferredoxin-NADP+ reductase reaction NADP radical, semiquinone and fully reduced enzyme-NADP+ charge transfer complex as the reaction intermediates -- In vivo deactivation/activation of ferredoxin-NADP+- oxidoreductase from the cyanobacteria Anabaena variabills -- Isolation from Desulfovibrio desulfuricans of a flavoprotein with NADH-H+ oxidoreductase activity towards a protein containing a rubredoxin-like center -- Microsomal electron transport system focused on NADPH-cytochrome P-450 reductase -- Time - resolved fluorescence spectroscopy on NADPH-cytochrome P-450 reductase -- Studies on the reactions of flavin- and nicotinamide nucleotide analogues with a bacterial electron-transferring flavoprotein -- Kinetics of ligand binding, amino acid sequence, and crystallization of Chlorobium and Chromatium flavocytochrome c. -- Redox properties of flavocytochrome c.

-- Electron transfer kinetics of phthalate oxygenase reductase, an iron sulfur center containing flavoprotein -- CD and potentiometry of the FAD of nitrate reductase -- Kinetic studies on glutamate synthase from Azospirillum bras ilense -- Redox interactions of the FAD in xanthine oxidase with other centers of the protein -- Laser flash photolysis studies of intramolecular electron transfer between the FAD and Fe/S II centers in xanthine oxidase -- Mechanism of action of chicken liver xanthine dehydrogenase -- Interconversion between O-dependent and NAD - dependent types of rat liver xanthine dehydrogenase -- Reactivity of chicken liver xanthine dehydrogenase containing artificial flavins -- The molybdenum cofactor of milk xanthine oxidase -- Isolation of a cDNA sequence coding for a part of xanthine dehydrogenase from rat liver -- FLAVIN BIOSYNTHESIS/ METABOLISM/ AND MEDICAL ASPECTS -- Biosynthesis of flavins and deazaflavins -- The icosahedral ß60 capsid of heavy riboflavin synthase (6,7- dimethyl-8-ribityllumazine synthase/riboflavin synthase) -- Characterization of human riboflavin-binding immunoglobulins -- Riboflavin uptake by isolated rat kidney cells -- Purification and characterization of the bifunctional enzyme FAD synthetase from Brevibacterium ammoniapenes -- An update on flavin metabolism in rats and humans -- Effects of quinacrine, tetracycline, adriamycin and chloroquine upon flavin metabolism in rats -- Role of flavoproteins in the neurotoxic action of MPTP -- Biosynthesis of flavoproteins -- Biological and Medical Aspects of D-Amino Acid Oxidase — Biogenesis and in vivo reaction with D-propargylglycine — -- Molecular and cellular biology of D-amino acid oxidase -- Localization of D-amino acid oxidase in rat cerebellum -- Biosynthesis of D-amino acid oxidase and molecular cloning of the cDNA -- Characterization of a partially purified nitroaryl reductase -- FLAVOENZYME HYDROXYLASES -- Crystallographic studies on the mechanism of hydroxybenzoate hydroxylase from Psudomonas fluorescens -- Applications of deuterium and tritium isotope effects to the elucidation of kinetic mechanisms of flavoprotein hydroxylases -- Chemical modification of tyrosine-38 in j>.-hydroxybenzoate hydroxylase from Pseudomonas fluorescens by 5'-Pfluorosulfonylbenzoyladenosine: A probe for the elucidation of the NADPH binding site? -- Phenol Complexes of Phenol Hydroxylase -- The involvement of SH-groups in cooperativity of phenol binding sites in phenol hydroxylase -- 6-Thiocyanate-FAD and 6-mercapto-FAD as active site probes of phenol hydroxylase -- Hysteretic behavior of anthranilate hydroxylase -- Redox potentials of salicylate hydroxylase -- The oxidative half-reaction of 2-methyl-3-hydroxypyridine-5 - carboxylic acid oxygenase from Pseudomonas sp. MA-1 -- Lipid stabilization of the flavin hydroperoxide in the microsomal flavin-containing monooxygenase -- FLAVIN-DEPENDENT BIOLUMINESCENCE -- One-electron transfers in flavin systems: Relevance to the postulated C1EEL mechanism in bacterial bioluminescence -- Characterization of new "bleached" products obtained on treating flavins and flavoproteins with dithionite -- Flavin-mediated hydrogen peroxide production by biological and chemical photosystems -- On the chemical mechanisms of bacterial luciferase, an updating -- Studies on the mechanism of bacterial bioluminescence. Evidence compatible with a one electron transfer process and a CIEEL mechanism in the luciferase reaction -- Structural analysis of bacterial luciferase -- Sequence similarity between the a subunit of luciferase from Vibrio harvevl and clostridial flavodoxin -- Isolation and characterization of a yellow fluorescent protein from Vibrio fischeri strain Y-1 -- Purification and characterization of an unusual nonfluores cent flavoprotein from Photobacterium leiognathi -- Purification and some properties of FP390 from P. phosphoreum -- STRUCTURE, MECHANISM, AND BIOSYNTHESIS OF FLAVOENZYMES CONTAINING COVALENTLY-BOUND FLAVINS -- 8α-Imidazolylflavins: Application of their redox and spectral properties to flavoenzyme systems -- X-ray study of flavoenzymes containing covalently bound flavins -- Structural studies of P-cresol methylhydroxylase -- The chemical and stereochemical course of oxidation of 4- ethylphenol and other 4-alkylphenols by ^-cresol methylhydroxylase -- Redox properties of trimethylamine dehydrogenase -- Redox properties of Escherichia coll fumarate reductase -- Reactions of lumiflavin with aminyl and a-amino radicals of piperazine -- Kinetic probes of the proposed radical mechanism of monoamine oxidase -- Stopped-flow studies on the mechanism of the oxidation of N—methyl - 4 - phenyl - 1 , 2 , 3 , 6 - tetrahydropyridine (HPTP) by monoamine oxidase -- Methoxatin containing methylamine dehydrogenase: Enzyme reduction by primary amines -- Interaction of bacterial sarcosine oxidase with folate derivatives -- Sulfhydryl groups and the binding site of noncovalently bound FAD ofCorvnebacterlum sarcosine oxidase -- Dimethylglycine dehydrogenase from pig liver mitochondria: Purification and properties -- Comparison of partial amino acid sequences deduced from the nucleotide sequence of a bovine adrenal monoamine oxidase cDNA clone to amino acid sequences obtained from bovine liver monoamine oxidase type B -- Covalent binding of FAD to Bacillus subtllis succinate dehydrogenase -- 6 - Hydroxy-D-nicotine oxidase: Expression of the flavoenzyme as a covalently flavinylated polypeptide -- The flavin-binding sites of 6-hydroxy-D- and 6-hydroxy-Lnicotine oxidase -- LIST OF PARTICIPANTS -- AUTHOR INDEX -- SUBJECT INDEX -- Backmatter