Adipokines 2.0

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Adipokines 2.0

Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and...

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Büchler, Christa
Year of Publication:2020
Language:English
Physical Description:1 electronic resource (406 p.)
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spelling Büchler, Christa auth
Adipokines 2.0
MDPI - Multidisciplinary Digital Publishing Institute 2020
1 electronic resource (406 p.)
text txt rdacontent
computer c rdamedia
online resource cr rdacarrier
Open access Unrestricted online access star
Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice.
English
lipids
cathepsins
neurodegeneration
tocilizumab
SGBS adipocytes
chemerin receptors
cholesterol
metabolically healthy obese
energy metabolism
adipose-brain axis
EP3 receptor
leptin
rheumatoid arthritis
excessive gestational weight gain
in vitro fat regain
secreted frizzled-related protein 5
PCOS
EP4 receptor
leukocyte
exchange protein directly activated by cAMP isoform 2 (EPAC2)
extracellular remodeling
insulin
osteoarthritis
lipid metabolism
fat mass
Tango bioassay
fatty liver
free fatty acids
label-free proteomic profiling
interleukin(IL)-33
sick fat
polycystic ovary syndrome
early-life programming
inflammation
gestational diabetes
glucose restriction
adipokines
neonatal anthropometry
epicardial adipose tissue (EAT)
oestrous cycle
Cardiovascular Diseases (CVDs)
triglycerides
G protein-coupled receptor 1
testicular pathologies
prognosis
ovary
ICU
biologic activity
preeclempsia
adipokine
critical illness
early pregnancy
myokine
liver steatosis
C-C chemokine receptor-like 2
testis
stimulating growth factor 2 (ST2)
pig
fitness
human granulosa cells
obesity
proteolysis
annexins
adipose tissue
biomarker
ghrelin
brain health
sepsis
adiponectin
rheumatic diseases
chemokine-like receptor 1
follicular fluid
glucose homeostasis
resistin
Nonalcoholic fatty liver disease
prostaglandin E2 (PGE2)
visceral fat
microglia
weight regain
complement factors
alpha-fetoprotein
polycystic ovary morphology
chemerin
cancer
depression
hypertension
hypothalamus
3-03928-586-6
language English
format eBook
author Büchler, Christa
spellingShingle Büchler, Christa
Adipokines 2.0
author_facet Büchler, Christa
author_variant c b cb
author_sort Büchler, Christa
title Adipokines 2.0
title_full Adipokines 2.0
title_fullStr Adipokines 2.0
title_full_unstemmed Adipokines 2.0
title_auth Adipokines 2.0
title_new Adipokines 2.0
title_sort adipokines 2.0
publisher MDPI - Multidisciplinary Digital Publishing Institute
publishDate 2020
physical 1 electronic resource (406 p.)
isbn 3-03928-587-4
3-03928-586-6
illustrated Not Illustrated
work_keys_str_mv AT buchlerchrista adipokines20
status_str n
ids_txt_mv (CKB)4100000011302218
(oapen)https://directory.doabooks.org/handle/20.500.12854/40131
(EXLCZ)994100000011302218
carrierType_str_mv cr
is_hierarchy_title Adipokines 2.0
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