Vitamin D - Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism : : Proceedings of the Third Workshop on Vitamin D, Asilomar, Pacific Grove, California, USA, January 1977 / / ed. by A. W. Norman, K. Schaefer, J. W. Coburn, D. v. Herrath, D. Fraser, H. G. Grigoleit, H. F. De Luca.
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Other title: | Frontmatter -- Foreword -- Contents -- List of Participants -- Vitamin D-Chemistry -- 19-Hydroxy-IOS (19)-Dihydrovitamin D3 and 25-Hydroxy-24-norvitamin D3 : Analogs with Anti-Metabolite Activity and Related Studies -- Synthesis and Separation of C-24 Epimers of some 24-Hydroxylated Vitamin D3 Analogs -- The 'Overirradiation Products' of Previtamin D and Tachysterol: Toxisterols -- Conformational Analysis of Vitamin D and its Analogs by Ultraviolet, Circular Dichroic, 1H and 13C NMR Spectroscopy -- I,25-Dihydroxyvitamin D3 from Solanum Glaucophyllum -- Synthesis and Conformational Analysis of Vitamin D Metabolites and Analogs -- A Stereoselective Synthesis of la, 24R, 25-Trihydroxycholecalciferol, a Metabolite of Vitamin D3 -- Crystal Structures and Empirical Force-Field Calculations of Some Steroids of the Vitamin D Series -- Approaches to the Synthesis of Vitamin D Metabolites and Analogs -- Conformational Analysis of Vitamin D: NMR and Force Field Calculations -- Vitamin D-Like Action of a Steroid from Trisetum Flavescens -- Vitamin D-Metabolism and Regulation -- Vitamin D3 Metabolism in Immature Japanese Quail: Effects of Ovarian Hormones -- Relationship of Intestinal Calcium and Phosphorus Absorption to Vitamin D Metabolism During Reproductive Activity of Birds -- On transcalciferin, the serum binding protein for 25-hydroxycholecalciferol -- Ultrastructural Alterations Produced by Vitamin D and its Metabolites on the Chick Parathyroid Gland -- Reduction of Parathyroid Hormone Secretion by 24, 25-Dihydroxy- Cholecalciferol (24, 25-DHCC) -- The Influence of Ca2+ Ions on the Metabolism of 25-Hydrcacy Cholecalciferol -- 1,25-Dihydroxyvitamin D3: Its Further Metabolism and the Regulation of its Biogenesis -- Disappearance from Plasma of Injected 3H-1,25- (OH)2-D3 in Healthy Humans -- Regulation of the Metabolism of 25(OH)D3: l,25(OH)2D3-Parathyroid Interactions -- Conversion of 7-Dehydrocholesterol to Vitamin D3 in Vivo: Isolation and Identification of Previtamin D3 from Skin -- Assessment of the Effects of 1,25-Dihydroxycholecalciferol (1,25-DHCC) on Parathyroid Secretion Rate in Calves -- Biological Activity of la,24-Dihydroxyvitamin D3; A New Synthetic Analog of the Hormonal Form of Vitamin D -- Metabolism of 1,25-Dihydroxyvitamin D3: Side Chain Oxidation in Vivo -- Calcium and Parathyroid Status in Normal Man Following Administration of 1,25-Dihydroxy-Vitamin D3 -- Comparative Aspects of the Biochemistry of the Regulation of Vitamin D Metabolism -- Aspects of the Control of Vitamin D Metabolism in Man -- Metabolism of 25-Hydroxycholecalciferol by Various Lines of Serially Cultured Kidney Cells -- Metabolism of 25-hydroxyvitamin D3 and Iα-hydroxyvitamin D3 in experimental rats with chronic renal failure -- Modulation of 25-Hydroxyvitamin D3 Metabolism by Iα,25-Dihydroxyvitamin D3 -- Circulating Iα,25-(OH)2D During Physiological States of Calcium -- Effect of Glucocorticoids on Vitamin D-Metabolism -- The Effects of Hypophysectomy on 25- Hydroxyvitamin D3 Metabolism in the Rat -- Regulation of the Metabolism of Vitamin D3 and 25-Hydroxyvitamin D3 -- The Effect of Anticonvulsants on Rat Liver Calciferol 25-hydroxylase -- Sex Hormonal Control of the Renal Vitamin D Hydroxylases -- The Subcellular Localization of 1,25-Dihydroxyvitamin D3 in the Parathyroid Glands of Chickens -- Vitamin D-Intestinal Action -- The Dissociation of 1,25(OH)2D3-induced CaBP Production and Alkaline Phosphatase Activity from Calcium Transport by Actinomycin D and Cycloheximide -- Regulation of the Messenger RNA for Calcium Binding Protein by 1,25- Dihydroxycholecalciferol -- Cyclic AMP Regulation of the Iα,25-(OH)2D3-Mediated Intestinal Calcium Absorptive Mechanism -- A Modified Procedure for the Isolation of Chick Intestinal Calcium Binding Protein -- Chemical Studies on Bovine Intestinal Calcium Binding Protein and Related Peptides Minor A and Minor B -- The Effect of Vitamin D Activity on Rat Renal and Intestinal Calcium Binding Proteins -- Mechanism of Action of 1α,25-Dihydroxyvitamin D3 at the Intestine and Parathyroids -- 1,25-Dihydroxyvitamin D2: Characterization, Receptor Affinity and Biological Activity in the Chick -- Recent studies on 1,25-(OH)2D3 Action in the Intestine -- The Role of Phosphate in the Intestinal Response to Vitamin D -- Distribution of Alkaline Phosphatase and Ca-ATPase in Intestinal Epithelial Cell Plasma Membranes: Differential Response to 1,25-(OH)2D3 -- The Relation between the Induction of Alkaline Phosphatase and 1,25-Dihydroxycholecalciferol Receptor in Chick Embryonic Duodenum -- Effects of Dietary Calcium and Phosphorus on the Steady State Levels of some Components of the Vitamin D Endocrine System -- Binding Components for Vitamin D3 Metabolites in Rat Intestine -- Light and Electron Microscopic Immunoperoxidase Localization of Chick Intestinal Vitamin D-Induced Calcium-Binding Protein -- The Effect of DDT on Vitamin D Metabolism and Calcium Binding Activity in the Chick -- Cytoplasmic Binding and Nuclear Uptake of Cholecalciferol Metabolites Inside Rat Duodenal Mucosa Cells -- Are the Cytosolic Binding Proteins for 25-Hydroxycholecalciferol Artifacts? -- Effects of Iα,25-Dihydroxyvitamin D3 on Active Intestinal Inorganic Phosphate Absorption -- Temporal Patterns of Response of the Intestinal Calcium Absorptive System and Related Parameters to 1,25-Dihydroxycholecalciferol -- Properties of Calcium and Magnesium Stimulated ATP'ase from Human Placenta -- The Effect of 1,25(OH)2D3 on Calcium Accumulation, Calcium Transport and Calcium Binding Protein in the Presence and Absence of Cycloheximide -- Vitamin D-Skeletal Action -- Effects of Vitamin D and its Metabolites on Bone -- Bone Cells as well as Bone Remodelling Surfaces in Renal Bone Disorders and Their Changes after Therapy — A Quantitative Analysis -- Localization of 3H-la,25-Dihydroxycholecalciferol in Rat Bone and Cartilage -- Vitamin D Dependent Bone Disease: Long-Term Responses to Vitamin D Analogs and Effect on Tetracycline Based Bone Dynamics -- The Dose-response Relationship of Tetracycline to the Detectability of Labeled Osteons by Fluorescence Microscopy -- Ultrastructural Studies of Bone - Influence of Vitamin D, PTH and Uremia on Bone Cell Ultrastructure and Bone Cell/Bone Matrix Interaction -- Multiple Isotope Indicator Studies of Bone Volume Changes in Rachitic and D Treated Rats -- Evaluation of a New Method for Studying Resorption by Isolated Bone Cells -- The effect of la-hydroxycholecalciferol on calcium balance and bone histology in a randomized trial -- The Effect of Vitamin D Steroles on Bone Histology in Incipient Renal Failure -- Action of Vitamin D Metabolites and Analogues, Parathyroid Hormone, Calcitonin and Steroid Sex Hormones on Bone in Tissue Culture -- Acid Phosphatase in Bone Cells from Vitamin D Deficient Rats -- Vitamin D — Renal Action -- The Effect of Vitamin D and its Metabolites on the Renal Handling of Phosphate -- Renal Handling of Calcium in Rats: Influence of Parathyroid Hormone and 1,25-Dihydroxyvitamin D3 -- Adaptive Mechanisms to Phosphate Depletion: The Role of Vitamin D -- The Effect of Different Solanum Malacoxylon Extracts on Urinary Calcium Excretion in Vitamin D Deficient Rats -- Quantitative Effect and Pathogenic Mechanism of la-Hydroxy- Cholecalciferol on the Renal Handling of Phosphate -- Failure of Intravenous Calcium to Restore PTH-Induced Phosphaturia in Pseudohypoparathyroidism Type II. A Case Report -- Effects of Vitamin D on Renal Tubular Calcium Transport -- Vitamin D-Metabolite Assays -- Assay of Vitamin D3 (Cholecalciferol) in Plasma Using Gas Chromatography/ Selected Ion Monitoring (GC/SIM) -- Development of a Radioimmunoassay for Vitamin D -- Radioimmunoassay of Human Serum DBP, and Competitive Binding Protein Radioassay of 24,25-(OH)2D -- Radioligand Receptor Assay for 1,25-Dihydroxyvitamin D: Biochemical, Physiologic and Clinical Applications -- Evolution of vitamin D serum transport proteins -- Application of High Pressure Liquid Chromatography for Assay of Vitamin D Metabolites -- Intestinal Cytosol Binders for 1,25-Dihydroxyvitamin D3 : Use in a Competitive Binding Protein Assay -- Some Problems Associated with the Assay of 25-Hydroxycholecalciferol in Human Serum -- Influence of Extraction on Saturation Analysis of 25-Hydroxy- Vitamin D (25-OH-D) without prior Chromatography -- An Assay for 24, 25 and 25, 26 Dihydroxycholecalciferols in sera -- A "25-Hydroxycholecalciferol-Like Compound" in Milk as Determined by Specific Competitive Binding Radioassays -- Specific binding of 25-Hydroxycholecalciferol in Human Mammary cancer -- Bone Organ Culture Bioassay for Determination of 1,25-(0H)2D -- The Measurement of 24, 25-Dihydroxycholecalciferol in Human Serum -- Plasma 25 (OH) Vitamin D levels in Normal Subjects throughout the year and in Patients with Related Diseases -- Vitamin D-Nutritional Aspects -- Cholecalciferol Production -- Biological Activity Evaluation of Chemically Synthesized Vitamin D Metabolites and Analogs -- Dose-Response of 1,25-Dihydroxycholecalciferol on Serum Calcium and Phosphorus, Urine Electrolytes and Hydroxyproline Excretion in Dairy Cattle -- Biochemical Response to 1,25 (OH)2 Vitamin D Supplementation in Premature Infants: A Prospective Study -- Effects of Vitamin D on Tissue Exchangeable Zinc -- Parturient Paresis Prophylaxis with 25-Hydroxycholecalciferol -- Serum and Renal Histologic Changes in the Rat Following Adminstation of Toxic Amounts of 1,25-Dihydroxyvitamin D3 -- Elevated 1,25-Dihydroxyvitamin D Levels in Plasma of Dairy Cows in Response to Parturient Hypocalcemia -- Environmental and Nutritional Influences on Plasma 25-Hydroxyvitamin D Concentration and Calcium Metabolism in Man -- Individual Differences in Susceptibility to Vitamin D-Induced Cardiovascular and Renal Damage: Need to Identify and Characterize its Toxic Metabolites -- Calcium Absorption and Calcium Balances in Man During Vitamin D Intake -- Potency of Natural and Artificial Ultra-Violet Irradiation as Determinants of Plasma 25-Hydroxyvitamin D in Man -- Biological Activity of 24R,25 and 24S,25-Dihydroxycholecalciferol (24R, 25 and 24S,25<OH)2D3) on Duodenal Calcium-Binding Protein (dCaBP) and Bone Calcium Mobilization in Rats -- I.25-Dihydroxyvitamin D3 and Jejunal Absorption of Calcium and Phosphate in Normal Subjects -- Vitamin D-Osteoporosis -- Vitamin D and Osteoporosis -- Long-Term Treatment of Osteoporotic Patients with 1α-OH-D3 and Calcium -- Evidence for Bihormonal Deficiency State (Estrogen and 1,25-Dihydroxyvitamin D) in Patients with Postmenopausal Osteoporosis -- Vitamin D-Renal Osteodystrophy -- 25 Hydroxyvitamin D in Renal Osteodystrophy: Results of a six-center Trial. Preliminary report -- Clincal Efficacy of 1,25-Dihydroxy-Vitamin D3 in Renal Osteodystrophy -- Comparison of l a Hydroxyvitamin D3 and 25 Hydroxyvitamin D3 in the Treatment of Renal Osteodystrophy. Greater Effect of 25 Hydroxyvitamin D3 in Mineralizing Bone -- Vitamin D, Osteomalacia, and Chronic Renal Failure -- Effects of 25 Hydroxycholecalciferol on Calcium Metabolism in Uremia -- The Effect of High Doses 5,6-Trans-25-Hydroxycholecalciferol on Calcium Metabolism in Relative Vitamin D Resistancy (Hypoparathyroidism and Chronic Renal Failure) -- Treatment of Renal Osteodystrophy in Children on Hemodialysis with Dihydrotachysterol (DHT) -- Growth and Bone Lesions in Experimental Uremia -- 1α-OH-D3 Induced Changes in Bone Related Parameters in Patients with Terminal Renal Failure before and after Kidney Transplantation -- Vitamin D-Other Clinical Topics -- The Effect of 1α Hydroxycholecalciferol on Secondary Hyperparathyroidism of Chronic Renal Failure -- 1α-Hydroxycholecalciferol and Phosphate Dialysis in Haemodialysis Osteodystrophy -- Clinical Efficacy of 5,6-Trans-25-OHCC in Chronic Renal Failure -- The Treatment of Renal Osteopathy with 5,6-Trans-25-OHCC. A Report of Experience made during a 32 months Therapy -- An Histologic Comparison of l,25(OH)2 Vitamin D Treatment with Calcium Supplementation in Renal Osteodystrophy -- Impaired l,25(OH)2D3 Production in Uremia in the Absence of Hyperphosphatemia or Kidney Damage -- Neonatal Hypocalcemia -- Hepatic Bioactivation of Vitamin D and Clinical Implications -- Sarcoidosis and its Relationship to Vitamin D -- Adult Vitamin-D Resistant Osteomalacia by Non Production of 25 OH-D -- Intestinal Absorption of Radiophosphate after Physiological Doses of 25(OH)D3 in Normals, Liver Cirrhosis and Chronic Renal Failure Patients -- Effects of Solanum Malacoxylon (SM) in Hypoparathyroidism -- Plasma Levels and Intestinal Absorption of 25-Hydroxyvitamin D after small Intestinal Resection -- Effect of Phenobarbital on Hepatic Vitamin D-25-Hydroxylase and Mixed Function Oxydases Activities in Vitro -- Vitamin D Resistant Rickets — Pathophysiology of the Various Syndromes -- The Effect of Phenobarbital (PB) Treatment on the Biliary Excretion of Cholecalciferol (D3) and 25-Hydroxy-Cholecalciferol (25-OHD3) in the D-Repleted Rat -- Effects of Metabolites and Analogues of Vitamin D3 in Hereditary Pseudo-Vitamin D Deficiency of Pigs -- Improvement of Fractional Intestinal 47Ca Absorption by 1,25-Dihydroxycholecalciferol in Patients on long-term Prednisone Treatment -- Biological Effects of 24,25-Dihydroxycholecalciferol in Man -- A Possible Mechanism for the Increased Urinary Calcium Excretion Induced by 1α Hydroxycholecalciferol Treatment to Hypoparathyroid Patients -- 25-Hydroxycholecalciferol Metabolism in Hepatobiliary Diseases -- Prophylactic Vitamin D Supplementation in Chronic Anticonvulsant Therapy -- The Treatment of Hypoparathyroidism with 25(OH)D3: Practical Conclusions and Metabolic Implications -- Plasma 250HD, Bone Mass Densitometry and 47Ca Intestinal Absorption Deficiency in Chronic Alcoholism -- Juvenile Rickets not Related to Vitamin D Deficiency -- 1,25-Dihydroxycholecalciferol: Oral Administration and Sterol Levels in the Long-Term Management of Idiopathic Hypoparathyroidism in Children -- Malabsorption of Vitamin D in Patients and Rat with Liver Cirrhosis -- Anticonvulsant Osteomalacia — An Overview -- 25-Hydroxyvitamin D Values in Chronic Liver Diseases and Response to Treatment with Parenteral Vitamin D -- 25-hydroxylation in chronic alcoholic liver disease -- Circulating 25-Hydroxyvitamin D Following Jejunal-Ileal Bypass -- Adult-Presenting Primary Hypophosphataemic Osteomalacia; Effects of Treatment with 1,25-Dihydroxycholecalciferol -- Influence of Vitamin D3 on Calcium Metabolism of the Newborn Infant -- Skeletal Mass and Serum Levels of 25-Hydroxyvitamin D in Postgastrectomy Patients -- Addendum -- Tumor Induced 1α,-25 Dihydroxycholecalciferol (1α,25-(OH)2D3) Deficiency: A Cause of Oncogenic Osteomalacia -- The Subcellular Distribution of 45Ca++-Effect of Warfarin/Antimycin A and Lanthanum -- Vitamin D and Pseudohypoparathyroidism -- Calcitonin load in patients with absorptive hypercalciuria -- Metabolism of 25-Hydroxyvitamin D3 (25-(OH)D3) in Primary Chick Kidney Cell Culture -- Bone Mineralisation and Plasma 25-OH Vitamin D in Chronic Renal Failure -- Histomorphometric Analysis of Trabecular Bone in Renal Dialysis Patients Treated with 25-Hydroxyvitamin D3: Preliminary Report -- Vitamin D Metabolites and Bone Mineralization In Man -- The Effect of la-OH-D3 Treatment on the Structure and Function of Chick Intestine Brush Border Membrane -- Solid-State Conformations of Vitamin D Molecules -- Fanconi Syndrome and its Relationship to Vitamin D -- Author Index -- Subject Index -- Backmatter |
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Format: | Mode of access: Internet via World Wide Web. |
ISBN: | 9783112327203 9783110637861 |
DOI: | 10.1515/9783112327203 |
Access: | restricted access |
Hierarchical level: | Monograph |
Statement of Responsibility: | ed. by A. W. Norman, K. Schaefer, J. W. Coburn, D. v. Herrath, D. Fraser, H. G. Grigoleit, H. F. De Luca. |
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