Study of intracellular signaling pathways in Chronic Myeloproliferative Neoplasms / / Serena Martinelli.

• Superior document: Premio Tesi di Dottorato
• VerfasserIn: Martinelli, Serena,
• Place / Publishing House: Florence : : Firenze University Press,, 2017.
• Yayın Tarihi: 2017
• Dil: English
• Seri Bilgileri: Premio tesi di dottorato.
• Fiziksel Özellikler: 1 online resource (80 pages).

A gain-of-function mutation in Janus kinase 2 (JAK2V617F) is at the basis of the majority of chronic myeloproliferative neoplasms (MPN). Enhanced activation of other downstream pathways including the PI3K/mTOR pathway has been documented as well. In this study we evaluated the effects of JAK1/2 inhi...