List of Publications

Neely, GG., Kuba, K., Cammarato, A (...) Bodmer, R., Penninger, JM. (2010). A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 141(1):142-53

Esk, C., Lindenhofer, D., Haendeler, S (...) von Haeseler, A., Knoblich, JA. (2020). A human tissue screen identifies a regulator of ER secretion as a brain-size determinant. Science. 370(6519):935-941

Elling, U., Wimmer, RA., Leibbrandt, A (...) Stark, A., Penninger, JM. (2017). A reversible haploid mouse embryonic stem cell biobank resource for functional genomics. Nature. 550(7674):114-118

Taubenschmid, J., Stadlmann, J., Jost, M (...) Koerner, C., Penninger, JM. (2017). A vital sugar code for ricin toxicity. Cell Res. 27(11):1351-1364

Taubenschmid-Stowers, J., Orthofer, M., Laemmerer, A (...) Horn, M., Penninger, JM. (2023). A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors. EMBO Mol Med. 15(3):e16959

Vainorius, G., Novatchkova, M., Michlits, G (...) Wernig, M., Elling, U. (2023). Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths. Nat Commun. 14(1):5341

Moussa, HF., Bsteh, D., Yelagandula, R (...) Frye, SV., Bell, O. (2019). Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing. Nat Commun. 10(1):1931

Stadlmann, J., Taubenschmid, J., Wenzel, D (...) Mechtler, K., Penninger, JM. (2017). Comparative glycoproteomics of stem cells identifies new players in ricin toxicity. Nature. 549(7673):538-542

Chylinski, K., Hubmann, M., Hanna, RE (...) Schramek, D., Elling, U. (2019). CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci. Nat Commun. 10(1):5454

Michlits, G., Hubmann, M., Wu, SH (...) Hoepfner, D., Elling, U. (2017). CRISPR-UMI: single-cell lineage tracing of pooled CRISPR-Cas9 screens. Nat Methods. 14(12):1191-1197

Elling, U., Woods, M., Forment, JV (...) Penninger, JM., Balmus, G. (2019). Derivation and maintenance of mouse haploid embryonic stem cells. Nat Protoc. 14(7):1991-2014

Butz, S., Schmolka, N., Karemaker, ID (...) Schübeler, D., Baubec, T. (2022). DNA sequence and chromatin modifiers cooperate to confer epigenetic bistability at imprinting control regions. Nat Genet.

Choi, J., Clement, K., Huebner, AJ (...) Meissner, A., Hochedlinger, K. (2017). DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells. Cell Stem Cell. 20(5):706-719.e7

Malik, B., Vokic, I., Mohr, T (...) Sibilia, M., Csiszar, A. (2023). FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice. EMBO Mol Med. 15(7):e16758

Elling, U., Taubenschmid, J., Wirnsberger, G (...) Stark, A., Penninger, JM. (2011). Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell. 9(6):563-74

Elling, U., Penninger, JM. (2014). Genome wide functional genetics in haploid cells. FEBS Lett. 588(15):2415-21

Kroef, V., Ruegenberg, S., Horn, M (...) Baumann, U., Denzel, MS. (2022). GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. Elife. 11

Boztug, K., Järvinen, PM., Salzer, E (...) Donadieu, J., Klein, C. (2014). JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Nat Genet. 46(9):1021-7

Wirnsberger, G., Zwolanek, F., Stadlmann, J (...) Elling, U., Penninger, JM. (2014). Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Nat Genet. 46(9):1028-33

Stephen, J., Nampoothiri, S., Banerjee, A (...) Gahl, WA., Malicdan, MCV. (2018). Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy. Hum Genet. 137(4):293-303

Devignot, S., Sha, TW., Burkard, TR (...) Penninger, JM., Weber, F. (2023). Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses. Life Sci Alliance. 6(7)

Michlits, G., Jude, J., Hinterndorfer, M (...) Zuber, J., Elling, U. (2020). Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles. Nat Methods. 17(7):708-716

Yelagandula, R., Bykov, A., Vogt, A (...) Cochella, L., Elling, U. (2021). Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq. Nat Commun. 12(1):3132

Elling, U., Klasen, C., Eisenberger, T., Anlag, K., Treier, M. (2006). Murine inner cell mass-derived lineages depend on Sall4 function. Proc Natl Acad Sci U S A. 103(44):16319-24

Breuss, M., Fritz, T., Gstrein, T (...) Elling, U., Keays, DA. (2016). Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. Development. 143(7):1126-33

Mor, N., Rais, Y., Sheban, D (...) Novershtern, N., Hanna, JH. (2018). Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency. Cell Stem Cell. 23(3):412-425.e10

Gieger, C., Radhakrishnan, A., Cvejic, A (...) Ouwehand, WH., Soranzo, N. (2011). New gene functions in megakaryopoiesis and platelet formation. Nature. 480(7376):201-8

John, L., Vernersson, C., Kwon, H (...) Penninger, JM., Mirazimi, A. (2022). Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study. Pathogens. 11(5)

Van Auken, K., Weaver, D., Robertson, B (...) Boese, Q., Wood, WB. (2002). Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis. Development. 129(22):5255-68

van der Harst, P., Zhang, W., Mateo Leach, I (...) Soranzo, N., Chambers, JC. (2012). Seventy-five genetic loci influencing the human red blood cell. Nature. 492(7429):369-75

Li, C., Fleck, JS., Martins-Costa, C (...) Treutlein, B., Knoblich, JA. (2023). Single-cell brain organoid screening identifies developmental defects in autism. Nature. 621(7978):373-380

Olivieri, D., Paramanathan, S., Bardet, AF (...) Elling, U., Betschinger, J. (2021). The BTB-domain transcription factor ZBTB2 recruits chromatin remodelers and a histone chaperone during the exit from pluripotency. J Biol Chem. 297(2):100947

Cheloufi, S., Elling, U., Hopfgartner, B (...) Zuber, J., Hochedlinger, K. (2015). The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 528(7581):218-24

Hagelkruys, A., Horrer, M., Taubenschmid-Stowers, J (...) Knoblich, JA., Penninger, JM. (2022). The HUSH complex controls brain architecture and protocadherin fidelity. Sci Adv. 8(44):eabo7247

Okamoto-Uchida, Y., Yu, R., Miyamura, N (...) Azuma, N., Nishina, H. (2016). The mevalonate pathway regulates primitive streak formation via protein farnesylation. Sci Rep. 6:37697

Ang, CE., Ma, Q., Wapinski, OL (...) Wernig, M., Chang, HY. (2019). The novel lncRNA <i>lnc-NR2F1</i> is pro-neurogenic and mutated in human neurodevelopmental disorders. Elife. 8

Schramek, D., Kotsinas, A., Meixner, A (...) Gorgoulis, VG., Penninger, JM. (2011). The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression. Nat Genet. 43(3):212-9

Romeike, M., Spach, S., Huber, M (...) Versteeg, GA., Buecker, C. (2022). Transient upregulation of IRF1 during exit from naive pluripotency confers viral protection. EMBO Rep. :e55375

Horn, M., Kroef, V., Allmeroth, K (...) Elling, U., Denzel, MS. (2018). Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells. Oncotarget. 9(11):9838-9851

Volz, JC., Schuller, N., Elling, U. (2019). Using Functional Genetics in Haploid Cells for Drug Target Identification. Methods Mol Biol. 1953:3-21

Yelagandula, R., Stecher, K., Novatchkova, M (...) Brennecke, J., Bell, O. (2023). ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers. Nat Cell Biol.