List of Publications

YearTitleJournalAuthors
2011Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.Naturede Lau, W., Barker, N., Low, TY., Koo, BK., Li, VS., Teunissen, H., Kujala, P., Haegebarth, A., Peters, PJ., van de Wetering, M., Stange, DE., van Es, JE., Guardavaccaro, D., Schasfoort, RB., Mohri, Y., Nishimori, K., Mohammed, S., Heck, AJ., Clevers, H.
2020Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.Cell Stem CellChoi, J., Park, JE., Tsagkogeorga, G., Yanagita, M., Koo, BK., Han, N., Lee, JH.
2009Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.J Clin InvestJeong, HW., Jeon, US., Koo, BK., Kim, WY., Im, SK., Shin, J., Cho, Y., Kim, J., Kong, YY.
2017Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.Nat MedBroutier, L., Mastrogiovanni, G., Verstegen, MM., Francies, HE., Gavarró, LM., Bradshaw, CR., Allen, GE., Arnes-Benito, R., Sidorova, O., Gaspersz, MP., Georgakopoulos, N., Koo, BK., Dietmann, S., Davies, SE., Praseedom, RK., Lieshout, R., IJzermans, JNM., Wigmore, SJ., Saeb-Parsy, K., Garnett, MJ., van der Laan, LJ., Huch, M.
2020Human organoids: model systems for human biology and medicine.Nat Rev Mol Cell BiolKim, J., Koo, BK., Knoblich, JA.
2020Human Microphysiological Models of Intestinal Tissue and Gut Microbiome.Front Bioeng BiotechnolSteinway, SN., Saleh, J., Koo, BK., Delacour, D., Kim, DH.
2019Human gastric cancer modelling using organoids.GutSeidlitz, T., Merker, SR., Rothe, A., Zakrzewski, F., von Neubeck, C., Grützmann, K., Sommer, U., Schweitzer, C., Schölch, S., Uhlemann, H., Gaebler, AM., Werner, K., Krause, M., Baretton, GB., Welsch, T., Koo, BK., Aust, DE., Klink, B., Weitz, J., Stange, DE.
2018How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing.Nucleic Acids ResBollen, Y., Post, J., Koo, BK., Snippert, HJG.
2021Genetic engineering in organoids.J Mol Med (Berl)Teriyapirom, I., Batista-Rocha, AS., Koo, BK.
2018Generation of FLIP and FLIP-FlpE Targeting Vectors for Biallelic Conditional and Reversible Gene Knockouts in Mouse and Human Cells.Methods Mol BiolKoo, BK.
2013Generation of BAC transgenic epithelial organoids.PLoS OneSchwank, G., Andersson-Rolf, A., Koo, BK., Sasaki, N., Clevers, H.
2020Gastric organoids-an in vitro model system for the study of gastric development and road to personalized medicine.Cell Death DifferSeidlitz, T., Koo, BK., Stange, DE.
2013Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.Cell Stem CellSchwank, G., Koo, BK., Sasselli, V., Dekkers, JF., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, CK., Nieuwenhuis, EE., Beekman, JM., Clevers, H.
2010Expression of an ASCL2 related stem cell signature and IGF2 in colorectal cancer liver metastases with 11p15.5 gain.GutStange, DE., Engel, F., Longerich, T., Koo, BK., Koch, M., Delhomme, N., Aigner, M., Toedt, G., Schirmacher, P., Lichter, P., Weitz, J., Radlwimmer, B.
2009Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development.J Biol ChemKwon, MC., Koo, BK., Kim, YY., Lee, SH., Kim, NS., Kim, JH., Kong, YY.
2013ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.Cell RepHeijmans, J., van Lidth de Jeude, JF., Koo, BK., Rosekrans, SL., Wielenga, MC., van de Wetering, M., Ferrante, M., Lee, AS., Onderwater, JJ., Paton, JC., Paton, AW., Mommaas, AM., Kodach, LL., Hardwick, JC., Hommes, DW., Clevers, H., Muncan, V., van den Brink, GR.
2019DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.GutKraiczy, J., Nayak, KM., Howell, KJ., Ross, A., Forbester, J., Salvestrini, C., Mustata, R., Perkins, S., Andersson-Rolf, A., Leenen, E., Liebert, A., Vallier, L., Rosenstiel, PC., Stegle, O., Dougan, G., Heuschkel, R., Koo, BK., Zilbauer, M.
2018DNA Methylation and Transcription Patterns in Intestinal Epithelial Cells From Pediatric Patients With Inflammatory Bowel Diseases Differentiate Disease Subtypes and Associate With Outcome.GastroenterologyHowell, KJ., Kraiczy, J., Nayak, KM., Gasparetto, M., Ross, A., Lee, C., Mak, TN., Koo, BK., Kumar, N., Lawley, T., Sinha, A., Rosenstiel, P., Heuschkel, R., Stegle, O., Zilbauer, M.
2018Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.CellNanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S., Koo, BK., Kanai, T., Sato, T.
2013Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.CellStange, DE., Koo, BK., Huch, M., Sibbel, G., Basak, O., Lyubimova, A., Kujala, P., Bartfeld, S., Koster, J., Geahlen, JH., Peters, PJ., van Es, JH., van de Wetering, M., Mills, JC., Clevers, H.