List of Publications

YearTitleJournalAuthors
2017Adult gastric stem cells and their niches.Wiley Interdiscip Rev Dev BiolBartfeld, S., Koo, BK.
2019Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology.VirusesKim, J., Koo, BK., Yoon, KJ.
2020Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss.Sci RepMorkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, BK., Dollé, P., Bloch-Zupan, A., Niederreither, K.
2015Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.Proc Natl Acad Sci U S AKoo, BK., van Es, JH., van den Born, M., Clevers, H.
2018ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.Proc Natl Acad Sci U S AHarris, A., Siggers, P., Corrochano, S., Warr, N., Sagar, D., Grimes, DT., Suzuki, M., Burdine, RD., Cong, F., Koo, BK., Clevers, H., Stévant, I., Nef, S., Wells, S., Brauner, R., Ben Rhouma, B., Belguith, N., Eozenou, C., Bignon-Topalovic, J., Bashamboo, A., McElreavey, K., Greenfield, A.
2013Generation of BAC transgenic epithelial organoids.PLoS OneSchwank, G., Andersson-Rolf, A., Koo, BK., Sasaki, N., Clevers, H.
2007An obligatory role of mind bomb-1 in notch signaling of mammalian development.PLoS OneKoo, BK., Yoon, MJ., Yoon, KJ., Im, SK., Kim, YY., Kim, CH., Suh, PG., Jan, YN., Kong, YY.
2017Stem Cells in Repair of Gastrointestinal Epithelia.Physiology (Bethesda)Andersson-Rolf, A., Zilbauer, M., Koo, BK., Clevers, H.
2018Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer.Open BiolSpit, M., Koo, BK., Maurice, MM.
2018Morphological alterations of cultured human colorectal matched tumour and healthy organoids.OncotargetKashfi, SMH., Almozyan, S., Jinks, N., Koo, BK., Nateri, AS.
2018How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing.Nucleic Acids ResBollen, Y., Post, J., Koo, BK., Snippert, HJG.
2008Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells.NeuronYoon, KJ., Koo, BK., Im, SK., Jeong, HW., Ghim, J., Kwon, MC., Moon, JS., Miyata, T., Kong, YY.
2011Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.Naturede Lau, W., Barker, N., Low, TY., Koo, BK., Li, VS., Teunissen, H., Kujala, P., Haegebarth, A., Peters, PJ., van de Wetering, M., Stange, DE., van Es, JE., Guardavaccaro, D., Schasfoort, RB., Mohri, Y., Nishimori, K., Mohammed, S., Heck, AJ., Clevers, H.
2012Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors.NatureKoo, BK., Spit, M., Jordens, I., Low, TY., Stange, DE., van de Wetering, M., van Es, JH., Mohammed, S., Heck, AJ., Maurice, MM., Clevers, H.
2020Human organoids: model systems for human biology and medicine.Nat Rev Mol Cell BiolKim, J., Koo, BK., Knoblich, JA.
2016Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.Nat ProtocBroutier, L., Andersson-Rolf, A., Hindley, CJ., Boj, SF., Clevers, H., Koo, BK., Huch, M.
2011Controlled gene expression in primary Lgr5 organoid cultures.Nat MethodsKoo, BK., Stange, DE., Sato, T., Karthaus, W., Farin, HF., Huch, M., van Es, JH., Clevers, H.
2017One-step generation of conditional and reversible gene knockouts.Nat MethodsAndersson-Rolf, A., Mustata, RC., Merenda, A., Kim, J., Perera, S., Grego, T., Andrews, K., Tremble, K., Silva, JC., Fink, J., Skarnes, WC., Koo, BK.
2017Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.Nat MedBroutier, L., Mastrogiovanni, G., Verstegen, MM., Francies, HE., Gavarró, LM., Bradshaw, CR., Allen, GE., Arnes-Benito, R., Sidorova, O., Gaspersz, MP., Georgakopoulos, N., Koo, BK., Dietmann, S., Davies, SE., Praseedom, RK., Lieshout, R., IJzermans, JNM., Wigmore, SJ., Saeb-Parsy, K., Garnett, MJ., van der Laan, LJ., Huch, M.
2020A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.Nat CommunTsukiyama, T., Zou, J., Kim, J., Ogamino, S., Shino, Y., Masuda, T., Merenda, A., Matsumoto, M., Fujioka, Y., Hirose, T., Terai, S., Takahashi, H., Ishitani, T., Nakayama, KI., Ohba, Y., Koo, BK., Hatakeyama, S.