List of Publications

2016Clonal Evolution of Stem Cells in the Gastrointestinal Tract.Adv Exp Med BiolFink, J., Koo, BK.
2021Post-translational Wnt receptor regulation: Is the fog slowly clearing?BioessaysTsukiyama, T., Koo, BK., Hatakeyama, S.
2016Rapid, one-step generation of biallelic conditional gene knockouts.BioRxivAndersson-Rolf A, Mustata RC, Merenda A, Perera S, Grego T, Kim J, Andrews K, Fink J, Skarnes WC, Koo BK.
2021SCON - A Short Conditional intrON for conditional knockout with one-step zygote injectionbioRxivWu, S-HS, Szep-Bakonyi R, Lee H, Colozza G, Boese A, Gert KR, Hallay N, Kim J, Zhu Y, Pilat-Carotta S, Theussl H-C, Pauli A, Koo B-K.
2008Defective Notch activation in microenvironment leads to myeloproliferative disease.BloodKim, YW., Koo, BK., Jeong, HW., Yoon, MJ., Song, R., Shin, J., Jeong, DC., Kim, SH., Kong, YY.
2015Adult stem cell lineage tracing and deep tissue imaging.BMB RepFink, J., Andersson-Rolf, A., Koo, BK.
2013Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium.CellStange, DE., Koo, BK., Huch, M., Sibbel, G., Basak, O., Lyubimova, A., Kujala, P., Bartfeld, S., Koster, J., Geahlen, JH., Peters, PJ., van Es, JH., van de Wetering, M., Mills, JC., Clevers, H.
2018Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.CellNanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S., Koo, BK., Kanai, T., Sato, T.
2020Gastric organoids-an in vitro model system for the study of gastric development and road to personalized medicine.Cell Death DifferSeidlitz, T., Koo, BK., Stange, DE.
2015 Stem cell-derived organoid cultures and genome editing tools. Cell Gene Therapy InsightsAndersson-Rolf A, Koo BK
2013ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.Cell RepHeijmans, J., van Lidth de Jeude, JF., Koo, BK., Rosekrans, SL., Wielenga, MC., van de Wetering, M., Ferrante, M., Lee, AS., Onderwater, JJ., Paton, JC., Paton, AW., Mommaas, AM., Kodach, LL., Hardwick, JC., Hommes, DW., Clevers, H., Muncan, V., van den Brink, GR.
2013Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.Cell Stem CellSchwank, G., Koo, BK., Sasselli, V., Dekkers, JF., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, CK., Nieuwenhuis, EE., Beekman, JM., Clevers, H.
2019Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.Cell Stem CellHan, S., Fink, J., Jörg, DJ., Lee, E., Yum, MK., Chatzeli, L., Merker, SR., Josserand, M., Trendafilova, T., Andersson-Rolf, A., Dabrowska, C., Kim, H., Naumann, R., Lee, JH., Sasaki, N., Mort, RL., Basak, O., Clevers, H., Stange, DE., Philpott, A., Kim, JK., Simons, BD., Koo, BK.
2015Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.Cell Stem CellSchuijers, J., Junker, JP., Mokry, M., Hatzis, P., Koo, BK., Sasselli, V., van der Flier, LG., Cuppen, E., van Oudenaarden, A., Clevers, H.
2020Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.Cell Stem CellChoi, J., Park, JE., Tsagkogeorga, G., Yanagita, M., Koo, BK., Han, N., Lee, JH.
2013Retroviral gene expression control in primary organoid cultures.Curr Protoc Stem Cell BiolKoo, BK., Sasselli, V., Clevers, H.
2016Simultaneous paralogue knockout using a CRISPR-concatemer in mouse small intestinal organoids.Dev BiolAndersson-Rolf, A., Merenda, A., Mustata, RC., Li, T., Dietmann, S., Koo, BK.
2016Organoids: A new in vitro model system for biomedical science and disease modelling and promising source for cell-based transplantation.Dev BiolKoo, BK., Huch, M.
2021Wnt/β-catenin signaling: structure, assembly and endocytosis of the signalosome.Dev Growth DifferColozza, G., Koo, BK.
2015Modeling mouse and human development using organoid cultures.DevelopmentHuch, M., Koo, BK.