List of Publications

YearTitleJournalAuthors
2015Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasia.Proc Natl Acad Sci U S AKoo, BK., van Es, JH., van den Born, M., Clevers, H.
2005Mind bomb-2 is an E3 ligase for Notch ligand.J Biol ChemKoo, BK., Yoon, KJ., Yoo, KW., Lim, HS., Song, R., So, JH., Kim, CH., Kong, YY.
2007An obligatory role of mind bomb-1 in notch signaling of mammalian development.PLoS OneKoo, BK., Yoon, MJ., Yoon, KJ., Im, SK., Kim, YY., Kim, CH., Suh, PG., Jan, YN., Kong, YY.
2019DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.GutKraiczy, J., Nayak, KM., Howell, KJ., Ross, A., Forbester, J., Salvestrini, C., Mustata, R., Perkins, S., Andersson-Rolf, A., Leenen, E., Liebert, A., Vallier, L., Rosenstiel, PC., Stegle, O., Dougan, G., Heuschkel, R., Koo, BK., Zilbauer, M.
2009Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development.J Biol ChemKwon, MC., Koo, BK., Kim, YY., Lee, SH., Kim, NS., Kim, JH., Kong, YY.
2008Crif1 is a novel transcriptional coactivator of STAT3.EMBO JKwon, MC., Koo, BK., Moon, JS., Kim, YY., Park, KC., Kim, NS., Kwon, MY., Kong, MP., Yoon, KJ., Im, SK., Ghim, J., Han, YM., Jang, SK., Shong, M., Kong, YY.
2008A crucial role of WW45 in developing epithelial tissues in the mouse.EMBO JLee, JH., Kim, TS., Yang, TH., Koo, BK., Oh, SP., Lee, KP., Oh, HJ., Lee, SH., Kong, YY., Kim, JM., Lim, DS.
2017A Protocol for Multiple Gene Knockout in Mouse Small Intestinal Organoids Using a CRISPR-concatemer.J Vis ExpMerenda, A., Andersson-Rolf, A., Mustata, RC., Li, T., Kim, H., Koo, BK.
2011The WNT antagonist Dickkopf2 promotes angiogenesis in rodent and human endothelial cells.J Clin InvestMin, JK., Park, H., Choi, HJ., Kim, Y., Pyun, BJ., Agrawal, V., Song, BW., Jeon, J., Maeng, YS., Rho, SS., Shim, S., Chai, JH., Koo, BK., Hong, HJ., Yun, CO., Choi, C., Kim, YM., Hwang, KC., Kwon, YG.
2021Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.J Exp MedMoon, S., Park, Y., Hyeon, S., Kim, YM., Kim, JH., Kim, H., Park, S., Lee, KJ., Koo, BK., Ha, SJ., Lee, SW.
2020Deficiency of the SMOC2 matricellular protein impairs bone healing and produces age-dependent bone loss.Sci RepMorkmued, S., Clauss, F., Schuhbaur, B., Fraulob, V., Mathieu, E., Hemmerlé, J., Clevers, H., Koo, BK., Dollé, P., Bloch-Zupan, A., Niederreither, K.
2012The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers.EMBO JMuñoz, J., Stange, DE., Schepers, AG., van de Wetering, M., Koo, BK., Itzkovitz, S., Volckmann, R., Kung, KS., Koster, J., Radulescu, S., Myant, K., Versteeg, R., Sansom, OJ., van Es, JH., Barker, N., van Oudenaarden, A., Mohammed, S., Heck, AJ., Clevers, H.
2018Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.CellNanki, K., Toshimitsu, K., Takano, A., Fujii, M., Shimokawa, M., Ohta, Y., Matano, M., Seino, T., Nishikori, S., Ishikawa, K., Kawasaki, K., Togasaki, K., Takahashi, S., Sukawa, Y., Ishida, H., Sugimoto, S., Kawakubo, H., Kim, J., Kitagawa, Y., Sekine, S., Koo, BK., Kanai, T., Sato, T.
2015Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.Cell Stem CellSchuijers, J., Junker, JP., Mokry, M., Hatzis, P., Koo, BK., Sasselli, V., van der Flier, LG., Cuppen, E., van Oudenaarden, A., Clevers, H.
2013Generation of BAC transgenic epithelial organoids.PLoS OneSchwank, G., Andersson-Rolf, A., Koo, BK., Sasaki, N., Clevers, H.
2013Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.Cell Stem CellSchwank, G., Koo, BK., Sasselli, V., Dekkers, JF., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, CK., Nieuwenhuis, EE., Beekman, JM., Clevers, H.
2019Mouse Models of Human Gastric Cancer Subtypes With Stomach-Specific CreERT2-Mediated Pathway Alterations.GastroenterologySeidlitz, T., Chen, YT., Uhlemann, H., Schölch, S., Kochall, S., Merker, SR., Klimova, A., Hennig, A., Schweitzer, C., Pape, K., Baretton, GB., Welsch, T., Aust, DE., Weitz, J., Koo, BK., Stange, DE.
2020Gastric organoids-an in vitro model system for the study of gastric development and road to personalized medicine.Cell Death DifferSeidlitz, T., Koo, BK., Stange, DE.
2019Human gastric cancer modelling using organoids.GutSeidlitz, T., Merker, SR., Rothe, A., Zakrzewski, F., von Neubeck, C., Grützmann, K., Sommer, U., Schweitzer, C., Schölch, S., Uhlemann, H., Gaebler, AM., Werner, K., Krause, M., Baretton, GB., Welsch, T., Koo, BK., Aust, DE., Klink, B., Weitz, J., Stange, DE.
2008Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development.J Exp MedSong, R., Kim, YW., Koo, BK., Jeong, HW., Yoon, MJ., Yoon, KJ., Jun, DJ., Im, SK., Shin, J., Kong, MP., Kim, KT., Yoon, K., Kong, YY.