List of Publications

2015 Stem cell-derived organoid cultures and genome editing tools. Cell Gene Therapy InsightsAndersson-Rolf A, Koo BK
2016Rapid, one-step generation of biallelic conditional gene knockouts.BioRxivAndersson-Rolf A, Mustata RC, Merenda A, Perera S, Grego T, Kim J, Andrews K, Fink J, Skarnes WC, Koo BK.
2014A video protocol of retroviral infection in primary intestinal organoid culture.J Vis ExpAndersson-Rolf, A., Fink, J., Mustata, RC., Koo, BK.
2016Simultaneous paralogue knockout using a CRISPR-concatemer in mouse small intestinal organoids.Dev BiolAndersson-Rolf, A., Merenda, A., Mustata, RC., Li, T., Dietmann, S., Koo, BK.
2017One-step generation of conditional and reversible gene knockouts.Nat MethodsAndersson-Rolf, A., Mustata, RC., Merenda, A., Kim, J., Perera, S., Grego, T., Andrews, K., Tremble, K., Silva, JC., Fink, J., Skarnes, WC., Koo, BK.
2017Stem Cells in Repair of Gastrointestinal Epithelia.Physiology (Bethesda)Andersson-Rolf, A., Zilbauer, M., Koo, BK., Clevers, H.
2017Adult gastric stem cells and their niches.Wiley Interdiscip Rev Dev BiolBartfeld, S., Koo, BK.
2019A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.Genes DevBasham, KJ., Rodriguez, S., Turcu, AF., Lerario, AM., Logan, CY., Rysztak, MR., Gomez-Sanchez, CE., Breault, DT., Koo, BK., Clevers, H., Nusse, R., Val, P., Hammer, GD.
2018How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing.Nucleic Acids ResBollen, Y., Post, J., Koo, BK., Snippert, HJG.
2016Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation.Nat ProtocBroutier, L., Andersson-Rolf, A., Hindley, CJ., Boj, SF., Clevers, H., Koo, BK., Huch, M.
2017Human primary liver cancer-derived organoid cultures for disease modeling and drug screening.Nat MedBroutier, L., Mastrogiovanni, G., Verstegen, MM., Francies, HE., Gavarró, LM., Bradshaw, CR., Allen, GE., Arnes-Benito, R., Sidorova, O., Gaspersz, MP., Georgakopoulos, N., Koo, BK., Dietmann, S., Davies, SE., Praseedom, RK., Lieshout, R., IJzermans, JNM., Wigmore, SJ., Saeb-Parsy, K., Garnett, MJ., van der Laan, LJ., Huch, M.
2020Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.Cell Stem CellChoi, J., Park, JE., Tsagkogeorga, G., Yanagita, M., Koo, BK., Han, N., Lee, JH.
2021Wnt/β-catenin signaling: structure, assembly and endocytosis of the signalosome.Dev Growth DifferColozza, G., Koo, BK.
2021Ub and Dub of RNF43/ZNRF3 in the WNT signalling pathway.EMBO RepColozza, G., Koo, BK.
2011Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.Naturede Lau, W., Barker, N., Low, TY., Koo, BK., Li, VS., Teunissen, H., Kujala, P., Haegebarth, A., Peters, PJ., van de Wetering, M., Stange, DE., van Es, JE., Guardavaccaro, D., Schasfoort, RB., Mohri, Y., Nishimori, K., Mohammed, S., Heck, AJ., Clevers, H.
2015Adult stem cell lineage tracing and deep tissue imaging.BMB RepFink, J., Andersson-Rolf, A., Koo, BK.
2016Clonal Evolution of Stem Cells in the Gastrointestinal Tract.Adv Exp Med BiolFink, J., Koo, BK.
2019Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.Cell Stem CellHan, S., Fink, J., Jörg, DJ., Lee, E., Yum, MK., Chatzeli, L., Merker, SR., Josserand, M., Trendafilova, T., Andersson-Rolf, A., Dabrowska, C., Kim, H., Naumann, R., Lee, JH., Sasaki, N., Mort, RL., Basak, O., Clevers, H., Stange, DE., Philpott, A., Kim, JK., Simons, BD., Koo, BK.
2018ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.Proc Natl Acad Sci U S AHarris, A., Siggers, P., Corrochano, S., Warr, N., Sagar, D., Grimes, DT., Suzuki, M., Burdine, RD., Cong, F., Koo, BK., Clevers, H., Stévant, I., Nef, S., Wells, S., Brauner, R., Ben Rhouma, B., Belguith, N., Eozenou, C., Bignon-Topalovic, J., Bashamboo, A., McElreavey, K., Greenfield, A.
2013ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.Cell RepHeijmans, J., van Lidth de Jeude, JF., Koo, BK., Rosekrans, SL., Wielenga, MC., van de Wetering, M., Ferrante, M., Lee, AS., Onderwater, JJ., Paton, JC., Paton, AW., Mommaas, AM., Kodach, LL., Hardwick, JC., Hommes, DW., Clevers, H., Muncan, V., van den Brink, GR.