Anna Christina Obenauf , PhD

Anna Christina Obenauf

Member of the Young Academy since 2019

  • Research Institute of Molecular Pathology (IMP)




Research Areas:

  • Biology
  • Cancer research
  • Immunology
  • Molecular biology
  • Genetics
  • Cell biology





Selected Memberships:

  • American Association for Cancer Research
  • Österreichische Gesellschaft für Humangenetik

Selected Prizes:

  • EMBO Young Investigator (YIP)
  • 2022 AAAS Martin and Rose Wachtel Cancer Research Award
  • ERC Starting Grant
  • ASCINA Award
  • Award of Excellence, BMBWF

Selected Publications:

  • Obenauf AC, Ji AL, Zou YZ, Vanharanta S, Shu W, Shi H, Kong X, Bosenberg MC, Wiesner T, Rosen N, Lo RS, Massague J. Therapy induced tumor secretomes promote resistance and cancer progression. Nature. 2015 Apr 16;520(7547):368-72..
  • Massague J, Obenauf AC. Metastatic colonization by circulating tumor cells. Nature. 2016 Jan 21;529:298–306.
  • Leiendecker L*, Jung PS*, Neumann T, Schleiffer A, Mechtler K, Wiesner T*, Obenauf AC*. LSD1 inhibitors induce neuronal differentiation of Merkel cell carcinoma by distrupting the LSD1-CoREST complex and activating TGFb signalling., EMBO Mol Med., 2020 Nov 6;12(11):e12525.
  • Umkehrer C, Holstein F, Formenti L, Jude J, Froussios K, Neumann T, Cronin SM, Haas L, Lipp JJ, Burkard TR, Fellner M, Wiesner T, Zuber J, Obenauf AC. CaTCH - A barcode-guided CRISPRa-inducible reporter to isolate clones from heterogeneous populations. Nature Biotechnology. 2020 Jul 27. doi: 10.1038/s41587-020-0614-0.
  • Haas L, Elewaut A, Gerard CL, Umkehrer C, Pedersen M, Leiendecker L, Krecioch I, Hoffmann D, Novatchkova M, Kuttke M, Neumann T, Pires de Silva I, Witthock H, Cuendet MA, Carotta S, Harrington KJ, Zuber J, Scolyer RA, Long GV, Wilmott JS, Michielin O, Vanharanta S, Wiesner T, Obenauf AC. Acquired resistance to targeted therapy confers cross-resistance to immunotherapy. Nature Cancer, 2021, in press.